Search Results - "Chiaradia, Louise Domeneghini"

Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: Kinetics, molecular modeling, toxicity and effect on growth by Mascarello, Alessandra, Chiaradia, Louise Domeneghini, Vernal, Javier, Villarino, Andrea, Guido, Rafael V.C., Perizzolo, Paulo, Poirier, Valerie, Wong, Dennis, Martins, Priscila Graziela Alves, Nunes, Ricardo José, Yunes, Rosendo Augusto, Andricopulo, Adriano Defini, Av-Gay, Yossef, Terenzi, Hernán

“…We have recently identified five synthetic chalcones which inhibit the activity of Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA), an enzyme…”
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Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus by Moreira Osório, Thaís, Delle Monache, Franco, Domeneghini Chiaradia, Louise, Mascarello, Alessandra, Regina Stumpf, Taisa, Roberto Zanetti, Carlos, Bardini Silveira, Douglas, Regina Monte Barardi, Célia, de Fatima Albino Smânia, Elza, Viancelli, Aline, Ariel Totaro Garcia, Lucas, Augusto Yunes, Rosendo, José Nunes, Ricardo, Smânia, Artur

“…Sixty-five synthetic or natural chalcones, hydrazones and oxadiazoles were assayed against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus…”
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Mycobacterium tuberculosis-Secreted Tyrosine Phosphatases as Targets Against Tuberculosis: Exploring Natural Sources in Searching for New Drugs by Mascarello, Alessandra, Chiaradia-Delatorre, Louise Domeneghini, Mori, Mattia, Terenzi, Hernán, Botta, Bruno

“…Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), which primarily affects the respiratory tract. Combinations of drugs are…”
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Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA by DOMENEGHINI CHIARADIA, Louise, MASCARELLO, Alessandra, PURIFICACAO, Marcela, VERNAL, Javier, SECHINI CORDEIRO, Marlon Norberto, ZENTENO, Maria Emilia, VILLARINO, Andréa, NUNES, Ricardo José, YUNES, Rosendo Augusto, TERENZI, Hernan

“…In the search for lead compounds for new drugs for tuberculosis, the activity of 38 synthetic chalcones were assayed for their potential inhibitory action…”
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Antihyperglycemic activity of naphthylchalcones by Damazio, Rosangela Guollo, Zanatta, Ana Paula, Cazarolli, Luisa Helena, Chiaradia, Louise Domeneghini, Mascarello, Alessandra, Nunes, Ricardo José, Yunes, Rosendo Augusto, Barreto Silva, Fátima Regina Mena

“…The purpose of the present work was to investigate, following previous works, naphthylchalcones as antihyperglycemic agent in glucose loaded animal model,…”
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Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products by Mascarello, Alessandra, Mori, Mattia, Chiaradia-Delatorre, Louise Domeneghini, Menegatti, Angela Camila Orbem, Delle Monache, Franco, Ferrari, Franco, Yunes, Rosendo Augusto, Nunes, Ricardo José, Terenzi, Hernán, Botta, Bruno, Botta, Maurizio

“…Protein tyrosine phosphatase B (PtpB) is one of the virulence factors secreted into the host cell by Mycobacterium tuberculosis. PtpB attenuates host immune…”
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Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death by Winter, Evelyn, Chiaradia, Louise Domeneghini, de Cordova, Clarissa A.S., Nunes, Ricardo José, Yunes, Rosendo Augusto, Creczynski-Pasa, Tânia Beatriz

“…In this study, we investigated the effects of 24 chalcone derivatives from 2-naphthylacetophenone toward a lymphoblastic leukemia cell line (L1210). Three…”
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Hydroxychalcones induce apoptosis in B16-F10 melanoma cells via GSH and ATP depletion by FORMENTO NAVARINI, Andréia Lilian, DOMENEGHINI CHIARADIA, Louise, MASCARELLO, Alessandra, FRITZEN, Marcio, NUNES, Ricardo José, YUNES, Rosendo Augusto, BEATRIZ CRECZYNSKI-PASA, Tania

“…Searching for leading compounds of new drugs for cancer therapy, we studied the toxicity of 13 hydroxychalcones never tested before toward melanoma cell line…”
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Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: Quantitative structure–activity relationships by Chiaradia, Louise Domeneghini, dos Santos, Rodrigo, Vitor, Carlos Eduardo, Vieira, André Alexandre, Leal, Paulo César, Nunes, Ricardo José, Calixto, João Batista, Yunes, Rosendo Augusto

“…Between 14 chalcones chemically derived from 2,4,6-trimethoxyacetophenone (five of them showed for the first time), eight inhibited the nitrite production in…”
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Anti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approaches by Ferreira, Natalia C, Marques, Icaro A, Conceição, Wesley A, Macedo, Bruno, Machado, Clarice S, Mascarello, Alessandra, Chiaradia-Delatorre, Louise Domeneghini, Yunes, Rosendo Augusto, Nunes, Ricardo José, Hughson, Andrew G, Raymond, Lynne D, Pascutti, Pedro G, Caughey, Byron, Cordeiro, Yraima

“…The prion protein (PrP) is implicated in the Transmissible Spongiform Encephalopathies (TSEs), which comprise a group of fatal neurodegenerative diseases…”
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A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia by de Souza, Ana C.A., Mori, Mattia, Sens, Larissa, Rocha, Ruth F., Tizziani, Tiago, de Souza, Luiz F.S., Domeneghini Chiaradia-Delatorre, Louise, Botta, Maurizio, Nunes, Ricardo J., Terenzi, Hernán, Menegatti, Angela C.O.

“…[Display omitted] •Novel chalcone derivatives with inhibitory activity of PTPs were synthesized.•Compound 3j exhibited remarkable irreversible non-competitive…”
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Chalcones to control Alternaria alternata in murcott tangor fruits by Camargos, Renato Barbosa, Perina, Fabiano José, Carvalho, Daniel Diego Costa, Alves, Eduardo, Mascarello, Alessandra, Chiaradia-Delatorre, Louise Domeneghini, Yunes, Rosendo Augusto, Nunes, Ricardo José, Oliveira, Denilson Ferreira

“…Alternaria brown spot (ABS), caused by the fungus Alternaria alternata pathotype tangerine, is one of the main phytosanitary problems for mandarin growers…”
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Novel synthetic chalcones induces apoptosis in human glioblastoma cells by Bittencourt, Lucas Felipe Fernandes, Oliveira, Karen Andrinéia de, Cardoso, Carine Bropp, Lopes, Flávia Garcia, Dal-Cim, Tharine, Chiaradia-Delatorre, Louise Domeneghini, Mascarello, Alessandra, Maluf, Sharbel Weidner, Yunes, Rosendo Augusto, Garcez, Ricardo Castilho, Tasca, Carla Inês, Nedel, Cláudia Beatriz

“…Glioblastoma multiforme is the main and most frequent tumor in adults' central nervous system. With a survival average of 5% two years after diagnosis, this…”
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Involvement of extrinsic and intrinsic apoptotic pathways together with endoplasmic reticulum stress in cell death induced by naphthylchalcones in a leukemic cell line: Advantages of multi-target action by Winter, Evelyn, Chiaradia, Louise Domeneghini, Silva, Adny Henrique, Nunes, Ricardo José, Yunes, Rosendo Augusto, Creczynski-Pasa, Tânia Beatriz

“…[Display omitted] •The chalcones induce apoptosis in leukemic cells by different pathways.•The chalcones induce intrinsic and extrinsic apoptosis.•The…”
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Synthesis, Biological Evaluation, And Molecular Modeling of Chalcone Derivatives As Potent Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatases (PtpA and PtpB) by Chiaradia, Louise Domeneghini, Martins, Priscila Graziela Alves, Cordeiro, Marlon Norberto Sechini, Guido, Rafael Victorio Carvalho, Ecco, Gabriela, Andricopulo, Adriano Defini, Yunes, Rosendo Augusto, Vernal, Javier, Nunes, Ricardo José, Terenzi, Hernán

“…Tuberculosis (TB) is a major infectious disease caused by Mycobacterium tuberculosis (Mtb). According to the World Health Organization (WHO), about 1.8 million…”
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Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation by Mielcke, Tânia R., Mascarello, Alessandra, Filippi-Chiela, Eduardo, Zanin, Rafael F., Lenz, Guido, Leal, Paulo César, Chirardia, Louise D., Yunes, Rosendo A., Nunes, Ricardo J., Battastini, Ana M.O., Morrone, Fernanda B., Campos, Maria M.

“…Gliomas are the most common and devastating tumors of the central nervous system (CNS). Many pieces of evidence point out the relevance of natural compounds…”
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Biochemical evaluation of a series of synthetic chalcone and hydrazide derivatives as novel inhibitors of cruzain from Trypanosoma cruzi by Borchhardt, Deise M., Mascarello, Alessandra, Chiaradia, Louise Domeneghini, Nunes, Ricardo J., Oliva, Glaucius, Yunes, Rosendo A., Andricopulo, Adriano D.

“…Chagas' disease, a parasitic infection widely distributed throughout Latin America, is a major public health problem with devastating consequences in terms of…”
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Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: Synthesis, biological evaluation, molecular modeling and structure–activity relationship (SAR) by Bello, Murilo Lamim, Chiaradia, Louise Domeneghini, Dias, Luiza Rosaria Sousa, Pacheco, Letícia Kramer, Stumpf, Taisa Regina, Mascarello, Alessandra, Steindel, Mário, Yunes, Rosendo Augusto, Castro, Helena Carla, Nunes, Ricardo José, Rodrigues, Carlos Rangel

“…In this work we described new trimethoxy-chalcones and among them 2i (IC50=2.7μM), 2j (IC50=3.9μM) and 2k (IC50=4.6μM) derivatives presented better…”
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Apoptotic events induced by synthetic naphthylchalcones in human acute leukemia cell lines by Maioral, Mariana Franzoni, Gaspar, Pâmela Cristina, Rosa Souza, Gabriela Regina, Mascarello, Alessandra, Chiaradia, Louise Domeneghini, Licínio, Marley Aparecida, Moraes, Ana Carolina Rabello, Yunes, Rosendo Augusto, Nunes, Ricardo José, Santos-Silva, Maria Cláudia

“…Acute leukemia is a disorder of the hematopoietic system characterized by the expansion of a clonal population of cells blocked from differentiating into…”
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Nitrochalcones: Potential in vivo insulin secretagogues by Damazio, Rosangela Guollo, Zanatta, Ana Paula, Cazarolli, Luisa Helena, Mascarello, Alessandra, Chiaradia, Louise Domeneghini, Nunes, Ricardo José, Yunes, Rosendo Augusto, Silva, Fátima Regina Mena Barreto

“…In this study, the in vivo and in vitro anti-hyperglycemic activity of chalcone derivatives of 3,4-methylenedioxy, with a substituent electron-acceptor nitro…”
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