Search Results - "Chiao, Paul"

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma by Hu, Kewen, Li, Kun, Lv, Jing, Feng, Jie, Chen, Jing, Wu, Haigang, Cheng, Feixiong, Jiang, Wenhao, Wang, Jieqiong, Pei, Haixiang, Chiao, Paul J, Cai, Zhenyu, Chen, Yihua, Liu, Mingyao, Pang, Xiufeng

“…Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis…”
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EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis by Yang, Weiwei, Xia, Yan, Cao, Yu, Zheng, Yanhua, Bu, Wen, Zhang, Lin, You, M. James, Koh, Mei Yee, Cote, Gilbert, Aldape, Kenneth, Li, Yi, Verma, Inder M., Chiao, Paul J., Lu, Zhimin

“…Many types of human tumor cells have overexpressed pyruvate kinase M2 (PKM2). However, the mechanism underlying this increased PKM2 expression remains to be…”
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KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma by Ling, Jianhua, Kang, Ya'an, Zhao, Ruiying, Xia, Qianghua, Lee, Dung-Fang, Chang, Zhe, Li, Jin, Peng, Bailu, Fleming, Jason B., Wang, Huamin, Liu, Jinsong, Lemischka, Ihor R., Hung, Mien-Chie, Chiao, Paul J.

“…Constitutive Kras and NF-κB activation is identified as signature alterations in pancreatic ductal adenocarcinoma (PDAC). However, how NF-κB is activated in…”
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TAK-ing aim at chemoresistance: The emerging role of MAP3K7 as a target for cancer therapy by Santoro, Raffaela, Carbone, Carmine, Piro, Geny, Chiao, Paul J., Melisi, Davide

“…Cellular drug resistance remains the main obstacle to the clinical efficacy of cancer chemotherapy. Alterations in key pathways regulating cell cycle…”
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Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation by Ju, Huai-Qiang, Gocho, Takeshi, Aguilar, Mitzi, Wu, Min, Zhuang, Zhuo-Nan, Fu, Jie, Yanaga, Katsuhiko, Huang, Peng, Chiao, Paul J

“…Pancreatic ductal adenocarcinoma (PDAC) frequently develops therapeutic resistances, which can be divided into extrinsic and intrinsic resistance. The…”
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The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1 by Zhang, Boyi, Fu, Da, Xu, Qixia, Cong, Xianling, Wu, Chunyan, Zhong, Xiaoming, Ma, Yushui, Lv, Zhongwei, Chen, Fei, Han, Liu, Qian, Min, Chin, Y. Eugene, Lam, Eric W. -F., Chiao, Paul, Sun, Yu

“…The senescence-associated secretory phenotype (SASP) can be provoked by side effects of therapeutic agents, fueling advanced complications including cancer…”
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IGFBP2 Activates the NF-κB Pathway to Drive Epithelial-Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma by Gao, Song, Sun, Yan, Zhang, Xuebin, Hu, Limei, Liu, Yuexin, Chua, Corrine Yingxuan, Phillips, Lynette M, Ren, He, Fleming, Jason B, Wang, Huamin, Chiao, Paul J, Hao, Jihui, Zhang, Wei

“…The molecular basis underlying the particularly aggressive nature of pancreatic ductal adenocarcinoma (PDAC) still remains unclear. Here we report evidence…”
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Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis by Chang, Zhe, Ju, Huaiqiang, Ling, Jianhua, Zhuang, Zhuonan, Li, Zhongkui, Wang, Huamin, Fleming, Jason B, Freeman, James W, Yu, Dihua, Huang, Peng, Chiao, Paul J

“…Activation of K-ras and inactivation of p16 are the most frequently identified genetic alterations in human pancreatic epithelial adenocarcinoma (PDAC). Mouse…”
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Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression by Chen, Dong-Liang, Lu, Yun-Xin, Zhang, Jia-Xing, Wei, Xiao-Li, Wang, Feng, Zeng, Zhao-Lei, Pan, Zhi-Zhong, Yuan, Yun-Fei, Wang, Feng-Hua, Pelicano, Helene, Chiao, Paul J, Huang, Peng, Xie, Dan, Li, Yu-Hong, Ju, Huai-Qiang, Xu, Rui-Hua

“…Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including colorectal cancer (CRC). However, the role of lncRNA in CRC liver…”
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K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis by Hu, Yumin, Lu, Weiqin, Chen, Gang, Wang, Peng, Chen, Zhao, Zhou, Yan, Ogasawara, Marcia, Trachootham, Dunyaporn, Feng, Li, Pelicano, Helene, Chiao, Paul J, Keating, Michael J, Garcia-Manero, Guillermo, Huang, Peng

“…Increased aerobic glycolysis and oxidative stress are important features of cancer cell metabolism, but the underlying biochemical and molecular mechanisms…”
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Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications by Ju, Huai-Qiang, Lu, Yun-Xin, Chen, Dong-Liang, Zuo, Zhi-Xiang, Liu, Ze-Xian, Wu, Qi-Nian, Mo, Hai-Yu, Wang, Zi-Xian, Wang, De-Shen, Pu, Heng-Ying, Zeng, Zhao-Lei, Li, Bo, Xie, Dan, Huang, Peng, Hung, Mien-Chie, Chiao, Paul J, Xu, Rui-Hua

“…Abstract Background Overcoming oxidative stress is a critical step for tumor progression; however, the underlying mechanisms in colorectal cancer (CRC) remain…”
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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate by Trachootham, Dunyaporn, Zhou, Yan, Zhang, Hui, Demizu, Yusuke, Chen, Zhao, Pelicano, Helene, Chiao, Paul J., Achanta, Geetha, Arlinghaus, Ralph B., Liu, Jinsong, Huang, Peng

“…Reactive oxygen species (ROS) stimulate cell proliferation and induce genetic instability, and their increase in cancer cells is often viewed as an adverse…”
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ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer by Ji, Shunrong, Qin, Yi, Shi, Si, Liu, Xiangyuan, Hu, Hongli, Zhou, Hu, Gao, Jing, Zhang, Bo, Xu, Wenyan, Liu, Jiang, Liang, Dingkong, Liu, Liang, Liu, Chen, Long, Jiang, Zhou, Haijun, Chiao, Paul J, Xu, Jin, Ni, Quanxing, Gao, Daming, Yu, Xianjun

“…F-box and WD repeat domain-containing 7 （FBW7） is the substrate recognition component of the Skpl-Cull-F- box （SCF） ubiquitin ligase complex and functions as a…”
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Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers by Garlapati, Pranavi, Ling, Jinjie, Chiao, Paul J, Fu, Jie

“…Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA…”
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FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer by Ji, Shunrong, Qin, Yi, Liang, Chen, Huang, Run, Shi, Si, Liu, Jiang, Jin, Kaizhou, Liang, Dingkong, Xu, Wenyan, Zhang, Bo, Liu, Liang, Liu, Chen, Xu, Jin, Ni, Quanxing, Chiao, Paul J, Li, Min, Yu, Xianjun

“…FBW7 functions as a tumor suppressor by targeting oncoproteins for destruction. We previously reported that the oncogenic mutation of KRAS inhibits the tumor…”
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Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma by Ju, Huai-Qiang, Ying, Haoqiang, Tian, Tian, Ling, Jianhua, Fu, Jie, Lu, Yu, Wu, Min, Yang, Lifeng, Achreja, Abhinav, Chen, Gang, Zhuang, Zhuonan, Wang, Huamin, Nagrath, Deepak, Yao, Jun, Hung, Mien-Chie, DePinho, Ronald A., Huang, Peng, Xu, Rui-Hua, Chiao, Paul J.

“…Kras activation and p16 inactivation are required to develop pancreatic ductal adenocarcinoma (PDAC). However, the biochemical mechanisms underlying these…”
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Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling by Glorieux, Christophe, Xia, Xiaojun, He, Yong-Qiao, Hu, Yumin, Cremer, Kelly, Robert, Annie, Liu, Junchen, Wang, Fen, Ling, Jianhua, Chiao, Paul J., Huang, Peng

“…K-ras mutations are major genetic events that drive cancer development associated with aggressive malignant phenotypes, while expression of the immune…”
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IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation by Zhuang, Zhuonan, Ju, Huai-Qiang, Aguilar, Mitzi, Gocho, Takashi, Li, Hao, Iida, Tomonori, Lee, Harold, Fan, Xiaoqiang, Zhou, Haijun, Ling, Jianhua, Li, Zhongkui, Fu, Jie, Wu, Min, Li, Min, Melisi, Davide, Iwakura, Yoichiro, Xu, Kesen, Fleming, Jason B, Chiao, Paul J

“…Constitutive NF-κB activation is identified in about 70% of pancreatic ductal adenocarcinoma (PDAC) cases and is required for oncogenic KRAS-induced PDAC…”
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Modulation of Pancreatic Cancer Chemoresistance by Inhibition of TAK1 by Melisi, Davide, Xia, Qianghua, Paradiso, Genni, Ling, Jianhua, Moccia, Tania, Carbone, Carmine, Budillon, Alfredo, Abbruzzese, James L., Chiao, Paul J.

“…Background TGF-β-activated kinase-1 (TAK1), a mitogen-activated protein kinase kinase kinase, functions in the activation of nuclear factor κB (NF-κB) and…”
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LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis by Melisi, Davide, Ishiyama, Satoshi, Sclabas, Guido M, Fleming, Jason B, Xia, Qianghua, Tortora, Giampaolo, Abbruzzese, James L, Chiao, Paul J

“…Most pancreatic cancer patients present with inoperable disease or develop metastases after surgery. Conventional therapies are usually ineffective in treating…”
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