Search Results - "Chiao, J W"

Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (Review) by WANG, Long G, CHIAO, J. W

“…Prostate cancer is one of the most commonly diagnosed cancers in men. The number of affected men is expected to rapidly increase as the population of males…”
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Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells by Cang, Shundong, Xu, Xiaobin, Ma, Yuehua, Liu, Delong, Chiao, J W

“…Hypoacetylation on histone H3 of human prostate cancer cells has been described. Little is known about the modifications of other histones from prostate cancer…”
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De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc by WANG, L. G, LIU, X. M, FANG, Y, DAI, W, CHIAO, F. B, PUCCIO, G. M, FENG, J, LIU, D, CHIAO, J. W

“…Natural isothiocyanates from cruciferous vegetables have been described as important dietary factors for prostate cancer prevention. Phenethyl isothiocyanate…”
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Deficient histone acetylation and excessive deacetylase activity as epigenomic marks of prostate cancer cells by CANG, Shundong, JINGYANG FENG, KONNO, Sensuke, LIYING HAN, KATHERINE LIU, SHARMA, Sansar C, CHOUDHURY, Muhammad, CHIAO, J. W

“…Aberrant epigenomic alterations include incorrect histone modifications involving altered expression of chromatin-modifying proteins. They contribute to gene…”
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Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells by Chiao, J W, Chung, F-L, Kancherla, R, Ahmed, T, Mittelman, A, Conaway, C C

“…The relation between the consumption of cruciferous vegetables and reduced prostate cancer occurrence has been documented, although the responsible…”
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Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer by Wang, L. G., Beklemisheva, A., Liu, X. M., Ferrari, A. C., Feng, J., Chiao, J. W.

“…Prostate carcinoma is characterized by the silencing of π‐class glutathione S‐transferase gene (GSTP1), which encodes a detoxifying enzyme. The silencing of…”
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Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis by YANG, Yang-Ming, CONAWAY, C. Clifford, CHIAO, J. W, WANG, Chung-Xiou, AMIN, Shantu, WHYSNER, John, WEI DAI, REINHARDT, Joel, CHUNG, Fung-Lung

“…Recent studies in cell culture have shown that isothiocyanates (ITCs) induce apoptosis via activation of mitogen-activated protein (MAP) kinases and p53…”
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Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells by XUDONG MA, YUQIANG FANG, BEKLEMISHEVA, Anastasia, WEI DAI, JINGYANG FENG, AHMED, Tauseef, DELONG LIU, CHIAO, J. W

“…Natural isothiocyanates, present in cruciferous vegetables and synthetic phenylhexyl isothiocyanate (PHI) are chemopreventive agents which act by blocking the…”
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Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate by Wang, L.G., Liu, X.M., Chiao, J.W.

“…Background: Prostate cancer usually progresses to androgen refractory after an initial anti-androgen treatment. The androgen receptor (AR) is a pivotal factor…”
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The Differentiation and Maturation Mediator for Human Myeloid Leukemia Cells Shares Homology With Neuroleukin or Phosphoglucose Isomerase by Xu, W., Seiter, K., Feldman, E., Ahmed, T., Chiao, J.W.

“…The identity of the maturation inducer capable of mediating the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells was…”
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Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption by CHIAO, J. W, MOONGA, B. S, YANG, Y. M, KANCHERLA, R, MITTELMAN, A, WU-WONG, J. R, AHMED, T

“…The causes for the propensity of metastasized prostate cancer cells to grow in bone and to induce osteoblastic lesions remain unresolved. Co-culture of human…”
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Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest by Chiao, Jen Wei, Wu, Hongyan, Ramaswamy, Gita, Conaway, C. Clifford, Chung, Fung-Lung, Wang, Longgui, Liu, Delong

“…Epidemiological surveys indicate that intake of cruciferous vegetables is inversely related to prostate cancer incidence, although the responsible dietary…”
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Modulation of growth of human prostate cancer cells by the N-acetylcysteine conjugate of phenethyl isothiocyanate by Chiao, J W, Chung, F, Krzeminski, J, Amin, S, Arshad, R, Ahmed, T, Conaway, C C

“…There is growing evidence that thiol conjugates of isothiocyanates present in cruciferous vegetables are effective cancer chemopreventive and potentially…”
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The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo by LULU LU, DELONG LIU, XUDONG MA, BEKLEMISHEV, Anastasia, SEITER, Karen, AHMED, Tauseef, CHIAO, J. W

“…Isothiocyanates are potent chemopreventive agents for carcinogen-induced cancers in rodents. The major mode of action for chemoprevention is cytoprotection…”
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Interaction of a small molecule Natura-α and STAT3-SH2 domain to block Y705 phosphorylation and inhibit lupus nephritis by Chiao, J.W., Melikian, Maxime, Han, Liying, Xue, Chengsen, Tsao, Allen, Wang, Luxi, Mencher, Simon K., Fallon, John, Solangi, Karim, Bertho, Gildas, Wang, Long G.

“…Natura-α binds SH2 domain of STAT3, forms H-bonds with Glu594 and Arg609, preventing Y705 phosphorylation. The efficacy was evaluated in lupus mice, Natura-α…”
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Development of human prostate cancer cells to neuroendocrine-like cells by interleukin-1 by Chiao, J W, Hsieh, T C, Xu, W, Sklarew, R J, Kancherla, R

“…Growth and development of some prostate epithelial cells are androgen-dependent. Non-androgenic hormones and growth factors may also influence prostate cells…”
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Establishment of prostate cancer spheres from a prostate cancer cell line after phenethyl isothiocyanate treatment and discovery of androgen-dependent reversible differentiation between sphere and neuroendocrine cells by Chen, Yamei, Cang, Shundong, Han, Liying, Liu, Christina, Yang, Patrick, Solangi, Zeeshan, Lu, Quanyi, Liu, Delong, Chiao, J W

“…Prostate cancer can transform from androgen-responsive to an androgen-independent phenotype. The mechanism responsible for the transformation remains unclear…”
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Growth modulation of human prostatic cancer cells by interleukin-1 and interleukin-1 receptor antagonist by Hsieh, T.C., Chiao, J.W.

“…The effects of interleukin-1 (IL-1α or IL-1β) on androgen-dependent LNCaP and androgen-independent JCA-1 human prostatic cancer cell proliferation were…”
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Neuroleukin mediated differentiation induction of myelogenous leukemia cells by Chiao, J.W., Xu, Wei, Seiter, Karen, Feldman, Eric, Ahmed, Tauseef

“…Leukemia cells enriched from peripheral blood of a patient with myelogenous leukemia were induced to differentiate with a purified T cell lymphokine…”
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Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation by Beklemisheva, Anastasia A., Feng, Jingyang, Yeh, Yunshin Albert, Wang, L. G., Chiao, J. W.

“…BACKGROUND The effects of phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, on androgen‐influenced growth of the prostate such as…”
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