Search Results - "Chiang, Mark Y."

Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma by Kiel, Mark J, Velusamy, Thirunavukkarasu, Betz, Bryan L, Zhao, Lili, Weigelin, Helmut G, Chiang, Mark Y, Huebner-Chan, David R, Bailey, Nathanael G, Yang, David T, Bhagat, Govind, Miranda, Roberto N, Bahler, David W, Medeiros, L Jeffrey, Lim, Megan S, Elenitoba-Johnson, Kojo S J

“…Splenic marginal zone lymphoma (SMZL), the most common primary lymphoma of spleen, is poorly understood at the genetic level. In this study, using whole-genome…”
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Childhood and Early Onset Glaucoma Classification and Genetic Profile in a Large Australasian Disease Registry by Knight, Lachlan S.W., Ruddle, Jonathan B., Taranath, Deepa A., Goldberg, Ivan, Smith, James E.H., Gole, Glen, Chiang, Mark Y., Willett, Faren, D’Mellow, Guy, Breen, James, Qassim, Ayub, Mullany, Sean, Elder, James E., Vincent, Andrea L., Staffieri, Sandra E., Kearns, Lisa S., Mackey, David A., Luu, Susie, Siggs, Owen M., Souzeau, Emmanuelle, Craig, Jamie E.

“…To report the relative frequencies of childhood and early onset glaucoma subtypes and their genetic findings in a large single cohort. Retrospective clinical…”
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Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function by K C, Rajan, Patel, Nehal R, Shenoy, Anoushka, Scallan, Joshua P, Chiang, Mark Y, Galazo, Maria J, Meadows, Stryder M

“…Zinc Finger MIZ-Type Containing 1 (Zmiz1), also known as ZIMP10 or RAI17, is a transcription cofactor and member of the Protein Inhibitor of Activated STAT…”
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The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia by Pinnell, Nancy, Yan, Ran, Cho, Hyo Je, Keeley, Theresa, Murai, Marcelo J., Liu, Yiran, Alarcon, Amparo Serna, Qin, Jason, Wang, Qing, Kuick, Rork, Elenitoba-Johnson, Kojo S.J., Maillard, Ivan, Samuelson, Linda C., Cierpicki, Tomasz, Chiang, Mark Y.

“…Pan-NOTCH inhibitors are poorly tolerated in clinical trials because NOTCH signals are crucial for intestinal homeostasis. These inhibitors might also promote…”
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Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A by Yashiro-Ohtani, Yumi, He, Yiping, Ohtani, Takuya, Jones, Mary E, Shestova, Olga, Xu, Lanwei, Fang, Terry C, Chiang, Mark Y, Intlekofer, Andrew M, Blacklow, Stephen C, Zhuang, Yuan, Pear, Warren S

“…Precise control of the timing and magnitude of Notch signaling is essential for the normal development of many tissues, but the feedback loops that regulate…”
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Firing up chromatin to forge T-ALL by Chiang, Mark Y.

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Tearing ATL apart to find HTLV's sinister plans by Chiang, Mark Y.

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Finding ARIEL under the sea of T-ALL circuits by Chiang, Mark Y.

“…In this issue of Blood , Tan et al report that ARIEL (ARID5B - inducing enhancer-associated long noncoding RNA) is a novel enhancer RNA (eRNA) that amplifies…”
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Proliferative Vitreoretinopathy Following Transscleral Diode Cyclophotocoagulation by Bai, Amelia, Sharma, Abhishek, Chiang, Mark Y.

“…Transscleral diode laser cyclophotocoagulation may trigger the development of proliferative vitreoretinopathy. Our article demonstrates one such case leading…”
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Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1 by Chiang, Mark Y., Xu, Mina L., Histen, Gavin, Shestova, Olga, Roy, Monideepa, Nam, Yunsun, Blacklow, Stephen C., Sacks, David B., Pear, Warren S., Aster, Jon C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma by Rakowski, Lesley A, Lehotzky, Erica A, Chiang, Mark Y

“…To improve the treatment strategies of T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), further efforts are needed to identify therapeutic targets…”
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Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia by Liu, Hudan, Chiang, Mark Y., Pear, Warren S.

“…NOTCH1 plays a central role in T-cell development and, when aberrantly activated, in acute T-cell lymphoblastic leukemia (T-ALL). As a transmembrane receptor…”
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Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders by Chiang, Mark Y, Radojcic, Vedran, Maillard, Ivan

“…This article highlights recent discoveries about Notch activation and its oncogenic functions in lymphoid malignancies, and discusses the therapeutic potential…”
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Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL by Rodriguez, Sonia, Abundis, Christina, Boccalatte, Francesco, Mehrotra, Purvi, Chiang, Mark Y., Yui, Mary A., Wang, Lin, Zhang, Huajia, Zollman, Amy, Bonfim-Silva, Ricardo, Kloetgen, Andreas, Palmer, Joycelynne, Sandusky, George, Wunderlich, Mark, Kaplan, Mark H., Mulloy, James C., Marcucci, Guido, Aifantis, Iannis, Cardoso, Angelo A., Carlesso, Nadia

“…Timed degradation of the cyclin-dependent kinase inhibitor p27 Kip1 by the E3 ubiquitin ligase F-box protein SKP2 is critical for T-cell progression into cell…”
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Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress by Melnick, Ashley F, Mullin, Carea, Lin, Karena, McCarter, Anna C, Liang, Shannon, Liu, Yiran E, Wang, Qing, Jerome, Nicole A, Choe, Elizabeth, Kunnath, Nicholas, Bodanapu, Geethika, Akter, Fatema, Magnuson, Brian, Kumar, Surinder, Lombard, David B, Muntean, Andrew G, Ljungman, Mats, Sekiguchi, JoAnn, Ryan, Russell J H, Chiang, Mark Y

“…Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL), but pan-Notch inhibitors showed excessive toxicity in clinical…”
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High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia by Chiang, Mark Y., Wang, Qing, Gormley, Anna C., Stein, Sarah J., Xu, Lanwei, Shestova, Olga, Aster, Jon C., Pear, Warren S.

“…Activating NOTCH1 mutations are frequent in human T-cell acute lymphoblastic leukemia (T-ALL) and Notch inhibitors (γ-secretase inhibitors [GSIs]) have…”
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Comparison of Anterior Segment Abnormalities in Individuals With FOXC1 and PITX2 Variants by Prem Senthil, Mallika, Knight, Lachlan S. W., Taranath, Deepa, Mackey, David A., Ruddle, Jonathan B., Chiang, Mark Y., Siggs, Owen M., Souzeau, Emmanuelle, Craig, Jamie E.

“…Axenfeld-Rieger syndrome encompasses a group of developmental disorders affecting the anterior chamber structures of the eye, with associated systemic features…”
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Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development by Wang, Qing, Yan, Ran, Pinnell, Nancy, McCarter, Anna C., Oh, Yeonjoo, Liu, Yiran, Sha, Cher, Garber, Noah F., Chen, Yitong, Wu, Qingqing, Ku, Chia-Jui, Tran, Ivy, Serna Alarcon, Amparo, Kuick, Rork, Engel, James Douglas, Maillard, Ivan, Cierpicki, Tomasz, Chiang, Mark Y.

“…Notch1 signaling must elevate to high levels in order to drive the proliferation of CD4−CD8− double-negative (DN) thymocytes and progression to the CD4+CD8+…”
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Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells by Chiang, Mark Y., Shestova, Olga, Xu, Lanwei, Aster, Jon C., Pear, Warren S.

“…The leukemia stem cell (LSC) hypothesis proposes that a subset of cells in the bulk leukemia population propagates the leukemia. We tested the LSC hypothesis…”
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NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species by Giambra, Vincenzo, Jenkins, Christopher R, Wang, Hongfang, Lam, Sonya H, Shevchuk, Olena O, Nemirovsky, Oksana, Wai, Carol, Gusscott, Sam, Chiang, Mark Y, Aster, Jon C, Humphries, R Keith, Eaves, Connie, Weng, Andrew P

“…The authors uncover a new mechanism for the regulation of the activity of leukemia-initiating cells in T-ALL. A subpopulation of stem cells with low amounts of…”
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