Search Results - "Chiam, Keng‐Hwee"

Cellular ageing of oral fibroblasts differentially modulates extracellular matrix organization by Atkuru, Srividya, Muniraj, Giridharan, Sudhaharan, Thankiah, Chiam, Keng‐Hwee, Wright, Graham Daniel, Sriram, Gopu

“…Background and Objectives Ageing is associated with an impaired cellular function that can affect tissue architecture and wound healing in gingival and…”
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Ciliary metachronal wave propagation on the compliant surface of Paramecium cells by Narematsu, Naoki, Quek, Raymond, Chiam, Keng-Hwee, Iwadate, Yoshiaki

“…Ciliary movements in protozoa exhibit metachronal wave‐like coordination, in which a constant phase difference is maintained between adjacent cilia. It is at…”
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Transcriptomics indicate nuclear division and cell adhesion not recapitulated in MCF7 and MCF10A compared to luminal A breast tumours by Goh, Jeremy Joon Ho, Goh, Corinna Jie Hui, Lim, Qian Wei, Zhang, Songjing, Koh, Cheng-Gee, Chiam, Keng-Hwee

“…Breast cancer (BC) cell lines are useful experimental models to understand cancer biology. Yet, their relevance to modelling cancer remains unclear. To better…”
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Divergent Strategies for Controlling the Nuclear Membrane Satisfy Geometric Constraints during Nuclear Division by Yam, Candice, He, Yue, Zhang, Dan, Chiam, Keng-Hwee, Oliferenko, Snezhana

“…Eukaryotes segregate chromosomes in “open” or “closed” mitosis, depending on whether their nuclear envelopes (NEs) break down or remain intact. Here we show…”
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Compressive forces driven by lateral actin fibers are a key to the nuclear deformation under uniaxial cell-substrate stretching by Tsukamoto, Shingo, Chiam, Keng-Hwee, Asakawa, Takumi, Sawasaki, Kaoru, Takesue, Naoyuki, Sakamoto, Naoya

“…Cells sense the direction of mechanical stimuli including substrate stretching and show morphological and functional responses. The nuclear deformation with…”
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Enhanced Delta-Notch Lateral Inhibition Model Incorporating Intracellular Notch Heterogeneity and Tension-Dependent Rate of Delta-Notch Binding that Reproduces Sprouting Angiogenesis Patterns by Koon, Yen Ling, Zhang, Songjing, Rahmat, Muhammad Bakhait, Koh, Cheng Gee, Chiam, Keng-Hwee

“…Endothelial cells adopt unique cell fates during sprouting angiogenesis, differentiating into tip or stalk cells. The fate selection process is directed by…”
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Dynamic swimming pattern of Pseudomonas aeruginosa near a vertical wall during initial attachment stages of biofilm formation by Khong, Nicole Zi-Jia, Zeng, Yukai, Lai, Soak-Kuan, Koh, Cheng-Gee, Liang, Zhao-Xun, Chiam, Keng-Hwee, Li, Hoi-Yeung

“…Studying the swimming behaviour of bacteria in 3 dimensions (3D) allows us to understand critical biological processes, such as biofilm formation. It is still…”
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A computational model for how cells choose temporal or spatial sensing during chemotaxis by Tan, Rui Zhen, Chiam, Keng-Hwee

“…Cell size is thought to play an important role in choosing between temporal and spatial sensing in chemotaxis. Large cells are thought to use spatial sensing…”
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Cellular Response to Substrate Rigidity Is Governed by Either Stress or Strain by Yip, Ai Kia, Iwasaki, Katsuhiko, Ursekar, Chaitanya, Machiyama, Hiroaki, Saxena, Mayur, Chen, Huiling, Harada, Ichiro, Chiam, Keng-Hwee, Sawada, Yasuhiro

“…Cells sense the rigidity of their substrate; however, little is known about the physical variables that determine their response to this rigidity. Here, we…”
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Design and construction of an equibiaxial cell stretching system that is improved for biochemical analysis by Ursekar, Chaitanya Prashant, Teo, Soo-Kng, Hirata, Hiroaki, Harada, Ichiro, Chiam, Keng-Hwee, Sawada, Yasuhiro

“…We describe the design and validation of an equibiaxial stretching device in which cells are confined to regions of homogeneous strain. Using this device, we…”
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p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion by Yamauchi, Shota, Hou, Yan Yan, Guo, Alvin Kunyao, Hirata, Hiroaki, Nakajima, Wataru, Yip, Ai Kia, Yu, Cheng-han, Harada, Ichiro, Chiam, Keng-Hwee, Sawada, Yasuhiro, Tanaka, Nobuyuki, Kawauchi, Keiko

“…Oncogenic Ras induces cell transformation and promotes an invasive phenotype. The tumor suppressor p53 has a suppressive role in Ras-driven invasion. However,…”
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Computational modeling reveals that a combination of chemotaxis and differential adhesion leads to robust cell sorting during tissue patterning by Tan, Rui Zhen, Chiam, Keng-Hwee

“…Robust tissue patterning is crucial to many processes during development. The "French Flag" model of patterning, whereby naïve cells in a gradient of…”
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The role of cell-matrix adhesion and cell migration in breast tumor growth and progression by Chong, Lor Huai, Yip, Ai Kia, Farm, Hui Jia, Mahmoud, Lamees N, Zeng, Yukai, Chiam, Keng-Hwee

“…During breast cancer progression, there is typically increased collagen deposition resulting in elevated extracellular matrix rigidity. This results in changes…”
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Enrichment and Identification of Neural Stem Cells in Neurospheres Using Rigidity-Tunable Gels by Chew, Sweelin, Zeng, Yukai, Khoo, David, Hong Yu, Mike Yuan, Ahmed, Sohail, Chiam, Keng-Hwee

“…Neural stem cells (NCSs) are integral to establishing models and regenerative medicine. To this day, there is an unmet need to enrich these cells from a…”
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POPX2 phosphatase regulates the KIF3 kinesin motor complex by Phang, Hui-Qun, Hoon, Jing-Ling, Lai, Soak-Kuan, Zeng, Yukai, Chiam, Keng-Hwee, Li, Hoi-Yeung, Koh, Cheng-Gee

“…The kinesin motors are important in the regulation of cellular functions such as protein trafficking, spindle organization and centrosome separation. In this…”
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Myosin concentration underlies cell size-dependent scalability of actomyosin ring constriction by Calvert, Meredith E K, Wright, Graham D, Leong, Fong Yew, Chiam, Keng-Hwee, Chen, Yinxiao, Jedd, Gregory, Balasubramanian, Mohan K

“…In eukaryotes, cytokinesis is accomplished by an actomyosin-based contractile ring. Although in Caenorhabditis elegans embryos larger cells divide at a faster…”
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Human mesenchymal stem cell basal membrane bending on gratings is dependent on both grating width and curvature by Zeng, Yukai, Wong, Sum Thai, Teo, Soo Kng, Leong, Kam W., Chiam, Keng-Hwee, Yim, Evelyn K. F.

“…The topography of the extracellular substrate provides physical cues to elicit specific downstream biophysical and biochemical effects in cells. An example of…”
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Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface by Zhang, Songjing, Chong, Lor Huai, Woon, Jessie Yong Xing, Chua, Theng Xuan, Cheruba, Elsie, Yip, Ai Kia, Li, Hoi-Yeung, Chiam, Keng-Hwee, Koh, Cheng-Gee

“…Biochemical signaling and mechano-transduction are both critical in regulating stem cell fate. How crosstalk between mechanical and biochemical cues influences…”
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MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility by Hirata, Hiroaki, Ku, Wei-Chi, Yip, Ai Kia, Ursekar, Chaitanya Prashant, Kawauchi, Keiko, Roy, Amrita, Guo, Alvin Kunyao, Vedula, Sri Ram Krishna, Harada, Ichiro, Chiam, Keng-Hwee, Ishihama, Yasushi, Lim, Chwee Teck, Sawada, Yasuhiro, Sokabe, Masahiro

“…MEKK1 (also known as MAP3K1), which plays a major role in MAPK signaling, has been implicated in mechanical processes in cells, such as migration. Here, we…”
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Loss of p53 Enhances NF-κB-Dependent Lamellipodia Formation by Guo, Alvin Kunyao, Hou, Yanyan, Hirata, Hiroaki, Yamauchi, Shota, Yip, Ai Kia, Chiam, Keng-Hwee, Tanaka, Nobuyuki, Sawada, Yasuhiro, Kawauchi, Keiko

“…Tumor suppressor p53 prevents tumorigenesis and tumor growth by suppressing the activation of several transcription factors, including nuclear factor‐κB…”
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