Search Results - "Chia-Yi Kuan"

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice by Bisht, Kanchan, Okojie, Kenneth A., Sharma, Kaushik, Lentferink, Dennis H., Sun, Yu-Yo, Chen, Hong-Ru, Uweru, Joseph O., Amancherla, Saipranusha, Calcuttawala, Zainab, Campos-Salazar, Antony Brayan, Corliss, Bruce, Jabbour, Lara, Benderoth, Jordan, Friestad, Bria, Mills, William A., Isakson, Brant E., Tremblay, Marie-Ève, Kuan, Chia-Yi, Eyo, Ukpong B.

“…Microglia are brain-resident immune cells with a repertoire of functions in the brain. However, the extent of their interactions with the vasculature and…”
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Early neutrophil infiltration is critical for inflammation-sensitized hypoxic-ischemic brain injury in newborns by Yao, Hui-Wen, Kuan, Chia-Yi

“…Neutrophils are the most abundant leukocytes and usually the first immune cell-type recruited to a site of infection or tissue damage. In asphyxiated neonates,…”
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Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA by Rongvaux, Anthony, Jackson, Ruaidhrí, Harman, Christian C.D., Li, Tuo, West, A. Phillip, de Zoete, Marcel R., Wu, Youtong, Yordy, Brian, Lakhani, Saquib A., Kuan, Chia-Yi, Taniguchi, Tadatsugu, Shadel, Gerald S., Chen, Zhijian J., Iwasaki, Akiko, Flavell, Richard A.

“…The mechanism by which cells undergo death determines whether dying cells trigger inflammatory responses or remain immunologically silent. Mitochondria play a…”
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Acute seizure activity in neonatal inflammation-sensitized hypoxia-ischemia in mice by June, Angelina, Matysik, Weronika, Marlicz, Maria, Zucker, Emily, Wagley, Pravin K, Kuan, Chia-Yi, Burnsed, Jennifer

“…To examine acute seizure activity and neuronal damage in a neonatal mouse model of inflammation-sensitized hypoxic-ischemic (IS-HI) brain injury utilizing…”
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Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects by Chen, Hong-Ru, Chen, Ching-Wen, Mandhani, Nandita, Short-Miller, Jonah C, Smucker, Marchelle R, Sun, Yu-Yo, Kuan, Chia-Yi

“…Growing evidence suggests that early-life interactions among genetic, immune, and environment factors may modulate neurodevelopment and cause psycho-cognitive…”
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Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier by Wang, Daren, El-Amouri, Salim S., Dai, Mei, Kuan, Chia-Yi, Hui, David Y., Brady, Roscoe O., Pan, Dao

“…To realize the potential of large molecular weight substances to treat neurological disorders, novel approaches are required to surmount the blood-brain…”
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Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia by Lee, Yi-Hsuan, Lin, Chun-Hua, Hsu, Pei-Chien, Sun, Yu-Yo, Huang, Yu-Jie, Zhuo, Jiun-Horng, Wang, Chen-Yu, Gan, Yu-Ling, Hung, Chia-Chi, Kuan, Chia-Yi, Shie, Feng-Shiun

“…The aryl hydrocarbon receptor (AhR) regulates peripheral immunity; but its role in microglia‐mediated neuroinflammation in the brain remains unknown. Here, we…”
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Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury by Chen, Hong-Ru, Chen, Ching-Wen, Kuo, Yi-Min, Chen, Brandon, Kuan, Irena S, Huang, Henry, Lee, Jolly, Anthony, Neil, Kuan, Chia-Yi, Sun, Yu-Yo

“…Monocytes belong to the mononuclear phagocyte system and are immune responders to tissue injury and infection. There were also reports of monocytes…”
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Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke by Su, Enming Joseph, Cao, Chunzhang, Fredriksson, Linda, Nilsson, Ingrid, Stefanitsch, Christina, Stevenson, Tamara K., Zhao, Juanjuan, Ragsdale, Margret, Sun, Yu-Yo, Yepes, Manuel, Kuan, Chia-Yi, Eriksson, Ulf, Strickland, Dudley K., Lawrence, Daniel A., Zhang, Li

“…Treatment of acute ischemic stroke with the thrombolytic tissue plasminogen activator (tPA) can significantly improve neurological outcomes; however,…”
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CCR2+ monocytes replenish border-associated macrophages in the diseased mouse brain by Wang, Lingxiao, Zheng, Jiaying, Zhao, Shunyi, Wan, Yushan, Wang, Meijie, Bosco, Dale B., Kuan, Chia-Yi, Richardson, Jason R., Wu, Long-Jun

“…Border-associated macrophages (BAMs) are tissue-resident macrophages that reside at the border of the central nervous system (CNS). Since BAMs originate from…”
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Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury by Kuan, Chia-Yi, Chen, Hong-Ru, Gao, Ning, Kuo, Yi-Min, Chen, Ching-Wen, Yang, Dianer, Kinkaid, Melissa M., Hu, Erding, Sun, Yu-Yo

“…Hypoxia-inducible factor-1α (HIF1α) is a major regulator of cellular adaptation to hypoxia and oxidative stress, and recent advances of prolyl-4-hydroxylase…”
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Stroke propensity in the Th3+/ mouse model of β-thalassemia intermedia by Sun, Yu-Yo, Yao, Hui-Wen, Chen, Hong-Ru, Chen, Ching-Wen, Kinkaid, Melissa M, Kuan, Chia-Yi

“…β-thalassemia is associated with multiple hematological and cerebrovascular symptoms linked to a hypercoagulable state that has not been fully replicated in…”
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Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction by Eidson, Lori N., Gao, Qingzeng, Qu, Hongyan, Kikuchi, Daniel S., Campos, Ana Carolina P., Faidley, Elizabeth A., Sun, Yu-Yo, Kuan, Chia-Yi, Pagano, Rosana L., Lassègue, Bernard, Tansey, Malú G., Griendling, Kathy K., Hernandes, Marina S.

“…Stroke is a multiphasic process involving a direct ischemic brain injury which is then exacerbated by the influx of immune cells into the brain tissue…”
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Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium by Kim, Young-Woong, Zara, Greta, Kang, HyunJun, Branciamore, Sergio, O’Meally, Denis, Feng, Yuxin, Kuan, Chia-Yi, Luo, Yingjun, Nelson, Michael S., Brummer, Alex B., Rockne, Russell, Chen, Zhen Bouman, Zheng, Yi, Cardoso, Angelo A., Carlesso, Nadia

“…Heterogeneity of endothelial cell (EC) populations reflects their diverse functions in maintaining tissue’s homeostasis. However, their phenotypic, molecular,…”
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(Phospho)creatine: the reserve and merry-go-round of brain energetics by Chen, Hong-Ru, DeGrauw, Ton, Kuan, Chia-Yi

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Fate mapping via CCR2-CreER mice reveals monocyte-to-microglia transition in development and neonatal stroke by Chen, Hong-Ru, Sun, Yu-Yo, Chen, Ching-Wen, Kuo, Yi-Min, Kuan, Irena S, Tiger Li, Zheng-Rong, Short-Miller, Jonah C, Smucker, Marchelle R, Kuan, Chia-Yi

“…Whether monocytes contribute to the brain microglial pool in development or after brain injury remains contentious. To address this issue, we generated…”
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Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone by López-Juárez, Alejandro, Howard, Jennifer, Ullom, Kristy, Howard, Lindsey, Grande, Andrew, Pardo, Andrea, Waclaw, Ronald, Sun, Yu-Yo, Yang, Dianer, Kuan, Chia-Yi, Campbell, Kenneth, Nakafuku, Masato

“…Neural stem cells (NSCs) reside in widespread regions along the lateral ventricle and generate diverse olfactory bulb (OB) interneuron subtypes in the adult…”
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Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism by Yang, Changjun, Lavayen, Bianca P., Liu, Lei, Sanz, Brian D., DeMars, Kelly M., Larochelle, Jonathan, Pompilus, Marjory, Febo, Marcelo, Sun, Yu-Yo, Kuo, Yi-Min, Mohamadzadeh, Mansour, Farr, Susan A., Kuan, Chia-Yi, Butler, Andrew A., Candelario-Jalil, Eduardo

“…Adropin is a highly-conserved peptide that has been shown to preserve endothelial barrier function. Blood-brain barrier (BBB) disruption is a key pathological…”
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Alteration of SLP2-like immunolabeling in mitochondria signifies early cellular damage in developing and adult mouse brain by Morozov, Yury M., Sun, Yu-Yo, Kuan, Chia-Yi, Rakic, Pasko

“…Mitochondria play a critical role in various pathways of regulated cell death. Here we propose a novel method for detection of initial derangement of…”
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Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation by Katayama, Kei-ichi, Melendez, Jaime, Baumann, Jessica M, Leslie, Jennifer R, Chauhan, Bharesh K, Nemkul, Niza, Lang, Richard A, Kuan, Chia-Yi, Zheng, Yi, Yoshida, Yutaka

“…The organization of neural progenitors in the developing mammalian neuroepithelium is marked by cadherin-based adherens junctions. Whereas RhoA, a founding…”
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