Search Results - "Chia, Shumei"

Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy by Sharma, Ankur, Cao, Elaine Yiqun, Kumar, Vibhor, Zhang, Xiaoqian, Leong, Hui Sun, Wong, Angeline Mei Lin, Ramakrishnan, Neeraja, Hakimullah, Muhammad, Teo, Hui Min Vivian, Chong, Fui Teen, Chia, Shumei, Thangavelu, Matan Thangavelu, Kwang, Xue Lin, Gupta, Ruta, Clark, Jonathan R., Periyasamy, Giridharan, Iyer, N. Gopalakrishna, DasGupta, Ramanuj

“…Chemo-resistance is one of the major causes of cancer-related deaths. Here we used single-cell transcriptomics to investigate divergent modes of…”
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Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration by Chia, Shumei, Leung, Thomas, Tan, Ivan

“…Mammalian cell cytoskeletal reorganization for efficient directional movement requires tight coordination of actomyosin and microtubule networks. In this…”
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Predicting heterogeneity in clone-specific therapeutic vulnerabilities using single-cell transcriptomic signatures by Suphavilai, Chayaporn, Chia, Shumei, Sharma, Ankur, Tu, Lorna, Da Silva, Rafael Peres, Mongia, Aanchal, DasGupta, Ramanuj, Nagarajan, Niranjan

“…While understanding molecular heterogeneity across patients underpins precision oncology, there is increasing appreciation for taking intra-tumor heterogeneity…”
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Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time by Chia, Shumei, Low, Joo-Leng, Zhang, Xiaoqian, Kwang, Xue-Lin, Chong, Fui-Teen, Sharma, Ankur, Bertrand, Denis, Toh, Shen Yon, Leong, Hui-Sun, Thangavelu, Matan T., Hwang, Jacqueline S. G., Lim, Kok-Hing, Skanthakumar, Thakshayeni, Tan, Hiang-Khoon, Su, Yan, Hui Choo, Siang, Hentze, Hannes, Tan, Iain B. H., Lezhava, Alexander, Tan, Patrick, Tan, Daniel S. W., Periyasamy, Giridharan, Koh, Judice L. Y., Gopalakrishna Iyer, N., DasGupta, Ramanuj

“…Genomics-driven cancer therapeutics has gained prominence in personalized cancer treatment. However, its utility in indications lacking biomarker-driven…”
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An AI‐assisted integrated, scalable, single‐cell phenomic‐transcriptomic platform to elucidate intratumor heterogeneity against immune response by Tostado, Christopher P., Da Ong, Lucas Xian, Heng, Joel Jia Wei, Miccolis, Carlo, Chia, Shumei, Seow, Justine Jia Wen, Toh, Yi‐Chin, DasGupta, Ramanuj

“…We present a novel framework combining single‐cell phenotypic data with single‐cell transcriptomic analysis to identify factors underpinning heterogeneity in…”
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A comparative study of tumour-on-chip models with patient-derived xenografts for predicting chemotherapy efficacy in colorectal cancer patients by Ong, Louis Jun Ye, Chia, Shumei, Wong, Stephen Qi Rong, Zhang, Xiaoqian, Chua, Huiwen, Loo, Jia Min, Chua, Wei Yong, Chua, Clarinda, Tan, Emile, Hentze, Hannes, Tan, Iain Beehuat, DasGupta, Ramanuj, Toh, Yi-Chin

“…Inter-patient and intra-tumour heterogeneity (ITH) have prompted the need for a more personalised approach to cancer therapy. Although patient-derived…”
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Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity by Ravasio, Andrea, Myaing, Myint Z., Chia, Shumei, Arora, Aditya, Sathe, Aneesh, Cao, Elaine Yiqun, Bertocchi, Cristina, Sharma, Ankur, Arasi, Bakya, Chung, Vin Yee, Greene, Adrienne C., Tan, Tuan Zea, Chen, Zhongwen, Ong, Hui Ting, Iyer, N. Gopalakrishna, Huang, Ruby YunJu, DasGupta, Ramanuj, Groves, Jay T., Viasnoff, Virgile

“…The Eph family of receptor tyrosine kinases is crucial for assembly and maintenance of healthy tissues. Dysfunction in Eph signaling is causally associated…”
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Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity by Ravasio, Andrea, Myaing, Myint Z., Chia, Shumei, Arora, Aditya, Sathe, Aneesh, Cao, Elaine Yiqun, Bertocchi, Cristina, Sharma, Ankur, Arasi, Bakya, Chung, Vin Yee, Greene, Adrienne C., Tan, Tuan Zea, Chen, Zhongwen, Ong, Hui Ting, Iyer, N. Gopalakrishna, Huang, Ruby YunJu, DasGupta, Ramanuj, Groves, Jay T., Viasnoff, Virgile

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity by Ravasio, Andrea, Myaing, Myint Z., Chia, Shumei, Arora, Aditya, Sathe, Aneesh, Cao, Elaine Yiqun, Bertocchi, Cristina, Sharma, Ankur, Arasi, Bakya, Chung, Vin Yee, Green, Adrianne C., Tan, Tuan Zea, Chen, Zhongwen, Ong, Hui Ting, Iyer, N. Gopalakrishna, Huang, Ruby YunJu, DasGupta, Ramanuj, Groves, Jay T., Viasnoff, Virgile

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer by Joanito, Ignasius, Wirapati, Pratyaksha, Zhao, Nancy, Nawaz, Zahid, Yeo, Grace, Lee, Fiona, Eng, Christine L. P., Macalinao, Dominique Camat, Kahraman, Merve, Srinivasan, Harini, Lakshmanan, Vairavan, Verbandt, Sara, Tsantoulis, Petros, Gunn, Nicole, Venkatesh, Prasanna Nori, Poh, Zhong Wee, Nahar, Rahul, Oh, Hsueh Ling Janice, Loo, Jia Min, Chia, Shumei, Cheow, Lih Feng, Cheruba, Elsie, Wong, Michael Thomas, Kua, Lindsay, Chua, Clarinda, Nguyen, Andy, Golovan, Justin, Gan, Anna, Lim, Wan-Jun, Guo, Yu Amanda, Yap, Choon Kong, Tay, Brenda, Hong, Yourae, Chong, Dawn Qingqing, Chok, Aik-Yong, Park, Woong-Yang, Han, Shuting, Chang, Mei Huan, Seow-En, Isaac, Fu, Cherylin, Mathew, Ronnie, Toh, Ee-Lin, Hong, Lewis Z., Skanderup, Anders Jacobsen, DasGupta, Ramanuj, Ong, Chin-Ann Johnny, Lim, Kiat Hon, Tan, Emile K. W., Koo, Si-Lin, Leow, Wei Qiang, Tejpar, Sabine, Prabhakar, Shyam, Tan, Iain Beehuat

“…The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. The underlying epithelial cell diversity remains…”
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Evolution of precision oncology‐guided treatment paradigms by DasGupta, Ramanuj, Yap, Aixin, Yaqing, Elena Yong, Chia, Shumei

“…Cancer treatment is gradually evolving from the classical use of nonspecific cytotoxic drugs targeting generic mechanisms of cell growth and proliferation…”
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Two high-yield complementary methods to sort cell populations by their 2D or 3D migration speed by Arora, Aditya, Niño, Jorge Luis Galeano, Myaing, Myint Zu, Chia, Shumei, Arasi, Bakya, Ravasio, Andrea, Huang, Ruby Yun-Ju, Dasgupta, Ramanuj, Biro, Maté, Viasnoff, Virgile

“…The potential to migrate is one of the most fundamental functions for various epithelial, mesenchymal, and immune cells. Image analysis of motile cell…”
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Ex vivo co-culture models for immunotherapy with patient-derived tumor infiltrating lymphocytes, peripheral blood mononuclear cells and autologous patient colorectal cancer (CRC) cell lines by Tan, Si Qi, Lee, Yunqin, Lee, Fiona Yi Xin, Wang, Who-Whong, Bok, Ke Xin, Kua, Lindsay, Lim, Wan Jun, Teo, Hui Min (Vivian), Chia, Shumei, Loo, Jia Min, Yeo, Eugene Shen Ann, Tan, Wah Siew, Toh, Ee-Lin, Chua, Clarinda, Koo, Si-Lin, Toh, Yi-Chin, Biswas, Subhra Kumar, Toh, Han Chong, Dasgupta, Ramanuj, Tan, Iain Beehuat

“…Abstract only…”
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Single-cell RNA-seq unveils divergent modes of chemoresistance in squamous cell carcinoma by Sharma, Ankur, Kumar, Vibhor, Cao, Elaine Yiqun, Leong, Hui Sun, Hakimullah, Muhammad, Ramakrishnan, Neeraja, Zhang, Xiaoqian, Chong, Fui Teen, Chia, Shumei, Thangavelu, Matan Thangavelu, Wong, Angeline Mei Lin, Kwang, Xue Lin, Tan, Daniel Shao-Weng, Periyasamy, Giridharan, Gopalakrishna Iyer, N., DasGupta, Ramanuj

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