Search Results - "Chi, Zhexu"

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome by Guo, Chuansheng, Xie, Shujun, Chi, Zhexu, Zhang, Jinhua, Liu, Yangyang, Zhang, Li, Zheng, Mingzhu, Zhang, Xue, Xia, Dajing, Ke, Yuehai, Lu, Linrong, Wang, Di

“…Reciprocal interactions between the metabolic system and immune cells play pivotal roles in diverse inflammatory diseases, but the underlying mechanisms remain…”
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Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages by Guo, Chuansheng, Chi, Zhexu, Jiang, Danlu, Xu, Ting, Yu, Weiwei, Wang, Zhen, Chen, Sheng, Zhang, Li, Liu, Qianyun, Guo, Xingchen, Zhang, Xue, Li, Wenxin, Lu, Linrong, Wu, Yingliang, Song, Bao-Liang, Wang, Di

“…Cholesterol metabolism has been linked to immune functions, but the mechanisms by which cholesterol biosynthetic signaling orchestrates inflammasome activation…”
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Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo by Chian, Song, Thapa, Ruby, Chi, Zhexu, Wang, Xiu Jun, Tang, Xiuwen

“…•Luteolin inhibits the Nrf2 pathway in mouse liver and in xenografted tumors.•Luteolin markedly inhibits the growth of xenograft tumors.•Luteolin enhances the…”
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Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages by Zhu, Kaixiang, Jin, Xuexiao, Chi, Zhexu, Chen, Sheng, Wu, Songquan, Sloan, Richard D., Lin, Xuai, Neculai, Dante, Wang, Di, Hu, Hu, Lu, Linrong

“…The nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3 (NLRP3) inflammasome is essential in inflammation and…”
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Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs by Wang, Xiu Jun, Li, Yinyan, Luo, Lin, Wang, Hongyan, Chi, Zhexu, Xin, Ai, Li, Xin, Wu, Jiaguo, Tang, Xiuwen

“…Oxaliplatin is an important drug in the treatment of advanced metastatic colorectal cancer. NF-E2 p45-related factor 2 (Nrf2) is a key transcription factor…”
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Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters by Yu, Weiwei, Wang, Zhen, Yu, Xiafei, Zhao, Yonghui, Xie, Zili, Zhang, Kailian, Chi, Zhexu, Chen, Sheng, Xu, Ting, Jiang, Danlu, Guo, Xingchen, Li, Mobai, Zhang, Jian, Fang, Hui, Yang, Dehang, Guo, Yuxian, Yang, Xuyan, Zhang, Xue, Wu, Yingliang, Yang, Wei, Wang, Di

“…Immunometabolism contributes to inflammation, but how activated macrophages acquire extracellular nutrients to fuel inflammation is largely unknown. Here, we…”
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Screening‐based identification of xanthone as a novel NLRP3 inflammasome inhibitor via metabolic reprogramming by Cui, Wenyu, Chen, Sheng, Chi, Zhexu, Guo, Xingchen, Zhang, Xiaobo, Zhong, Yueyang, Han, Haijie, Yao, Ke

“…Dear Editor, The NLRP3 inflammasome is an intracellular surveillance multimolecule platform that senses broad ranges of pathogen-derived, environmental, and…”
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One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages by Yu, Weiwei, Wang, Zhen, Zhang, Kailian, Chi, Zhexu, Xu, Ting, Jiang, Danlu, Chen, Sheng, Li, Wenxin, Yang, Xuyan, Zhang, Xue, Wu, Yingliang, Wang, Di

“…Activated macrophages adapt their metabolic pathways to drive the pro-inflammatory phenotype, but little is known about the biochemical underpinnings of this…”
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Reconstitution System of NLRP3 Inflammasome in HEK293T Cells by Chen, Sheng, Chi, Zhexu, Wang, Di

“…NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is a cytosolic multimeric protein complex that plays key roles in the host innate immune…”
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Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation by Chi, Zhexu, Chen, Sheng, Xu, Ting, Zhen, Wenxuan, Yu, Weiwei, Jiang, Danlu, Guo, Xingchen, Wang, Zhen, Zhang, Kailian, Li, Mobai, Zhang, Jian, Fang, Hui, Yang, Dehang, Ye, Qizhen, Yang, Xuyan, Lin, Hui, Yang, Fan, Zhang, Xue, Wang, Di

“…Immune cell function depends on specific metabolic programs dictated by mitochondria, including nutrient oxidation, macromolecule synthesis, and…”
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Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome by Guo, Chuansheng, Xie, Shujun, Chi, Zhexu, Zhang, Jinhua, Liu, Yangyang, Zhang, Li, Zheng, Mingzhu, Zhang, Xue, Xia, Dajing, Ke, Yuehai, Lu, Linrong, Wang, Di

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Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation by Xu, Ting, Yu, Weiwei, Fang, Hui, Wang, Zhen, Chi, Zhexu, Guo, Xingchen, Jiang, Danlu, Zhang, Kailian, Chen, Sheng, Li, Mobai, Guo, Yuxian, Zhang, Jian, Yang, Dehang, Yu, Qianzhou, Wang, Di, Zhang, Xue

“…The NLRP3 (NOD−, LRR− and pyrin domain-containing protein 3) inflammasome plays a pivotal role in defending the host against infection as well as sterile…”
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Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption by Li, Mobai, Yang, Dehang, Yan, Huige, Tang, Zhibin, Jiang, Danlu, Zhang, Jian, Chi, Zhexu, Nie, Wanyun, Zhen, Wenxuan, Yu, Weiwei, Chen, Sheng, Wang, Zhen, Yu, Qianzhou, Zhang, Xue, Yang, Fan, Fan, Shunwu, Lin, Xianfeng, Wang, Di

“…Gasdermin D (GSDMD)-mediated pyroptosis induces immunogenic cell death and promotes inflammation. However, the functions of GSDMD in tissue homeostasis remain…”
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Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1 by Chen, Sheng, Cui, Wenyu, Chi, Zhexu, Xiao, Qian, Hu, Tianyi, Ye, Qizhen, Zhu, Kaixiang, Yu, Weiwei, Wang, Zhen, Yu, Chengxuan, Pan, Xiang, Dai, Siqi, Yang, Qi, Jin, Jiacheng, Zhang, Jian, Li, Mobai, Yang, Dehang, Yu, Qianzhou, Wang, Quanquan, Yu, Xiafei, Yang, Wei, Zhang, Xue, Qian, Junbin, Ding, Kefeng, Wang, Di

“…The tumor microenvironment (TME) is a unique niche governed by constant crosstalk within and across all intratumoral cellular compartments. In particular,…”
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A rapid administration of GW4064 inhibits the NLRP3 inflammasome activation independent of farnesoid X receptor agonism by Xie, Shujun, Guo, Chuansheng, Chi, Zhexu, Huang, Bo, Wu, Yihua, Wang, Di, Xia, Dajing

“…GW4064 is a small molecule known to be an agonist of the nuclear farnesoid X receptor (FXR). We found that GW4064 inhibits the NLR family CARD domain…”
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AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation by Guo, Xingchen, Chen, Sheng, Yu, Weiwei, Chi, Zhexu, Wang, Zhen, Xu, Ting, Zhang, Jian, Jiang, Danlu, Guo, Yuxian, Fang, Hui, Zhang, Kailian, Li, Mobai, Yang, Dehang, Yu, Qianzhou, Ye, Qizhen, Wang, Di, Zhang, Xue, Wu, Yingliang

“…The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase‐1 activation and interleukin‐1β maturation and drives cell fate…”
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Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation by Zhang, Jian, Yu, Qianzhou, Jiang, Danlu, Yu, Kang, Yu, Weiwei, Chi, Zhexu, Chen, Sheng, Li, Mobai, Yang, Dehang, Wang, Zhen, Xu, Ting, Guo, Xingchen, Zhang, Kailian, Fang, Hui, Ye, Qizhen, He, Yong, Zhang, Xue, Wang, Di

“…Goblet cells and their main secretory product, mucus, play crucial roles in orchestrating the colonic host-microbe interactions that help maintain gut…”
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Gasdermin D-mediated metabolic crosstalk promotes tissue repair by Chi, Zhexu, Chen, Sheng, Yang, Dehang, Cui, Wenyu, Lu, Yang, Wang, Zhen, Li, Mobai, Yu, Weiwei, Zhang, Jian, Jiang, Yu, Sun, Ruya, Yu, Qianzhou, Hu, Tianyi, Lu, Xiaoyang, Deng, Qiqi, Yang, Yidong, Zhao, Tianming, Chang, Mengfei, Li, Yuying, Zhang, Xue, Shang, Min, Xiao, Qian, Ding, Kefeng, Wang, Di

“…The establishment of an early pro-regenerative niche is crucial for tissue regeneration 1 , 2 . Gasdermin D (GSDMD)-dependent pyroptosis accounts for the…”
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Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer by Wang, Hongyan, Liu, Kaihua, Chi, Zhexu, Zhou, Xihang, Ren, Guoping, Zhou, Ren, Li, Yinyan, Tang, Xiuwen, Wang, Xiu Jun

“…Alterations in KEAP1/ NF-E2 p45-related factor 2 (NFE2L2/Nrf2) signaling pathway have been reported in 23% lung adenocarcinoma patients, suggesting that…”
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Protein phosphatase 2A propels follicular T helper cell development in lupus by Jiang, Yu, Jin, Xuexiao, Chi, Zhexu, Bai, Yadan, Manthiram, Kalpana, Mudd, Pamela, Zhu, Kaixiang, Wang, Lie, Schwartzberg, Pamela L., Han, Yongmei, Gao, Xiang, Lu, Linrong, Xu, Qin

“…Follicular helper T (Tfh) cells are important for generating humoral immune responses by helping B cells form germinal centers (GCs) and the production of…”
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