Search Results - "Chi, Susan N"

Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies by Frühwald, Michael C, Biegel, Jaclyn A, Bourdeaut, Franck, Roberts, Charles W M, Chi, Susan N

“…Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant CNS tumor of children below 6 months of age. The majority of AT/RTs demonstrate genomic…”
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Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma by PAUGH, Barbara S, BRONISCER, Alberto, ONAR-THOMAS, Arzu, BAKER, Justin N, GAJJAR, Amar, ELLISON, David W, BAKER, Suzanne J, CHUNXU QU, MILLER, Claudia P, JUNYUAN ZHANG, TATEVOSSIAN, Ruth G, OLSON, James M, GEYER, J. Russell, CHI, Susan N, DA SILVA, Nasjla Saba

“…Long-term survival for children with diffuse intrinsic pontine glioma (DIPG) is less than 10%, and new therapeutic targets are urgently required. We evaluated…”
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Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival by Marinoff, Amanda E., Ma, Clement, Guo, Dongjing, Snuderl, Matija, Wright, Karen D., Manley, Peter E., Al-Sayegh, Hasan, Sinai, Claire E., Ullrich, Nicole J., Marcus, Karen, Haas-Kogan, Daphne, Goumnerova, Liliana, London, Wendy B., Kieran, Mark W., Chi, Susan N., Fangusaro, Jason, Bandopadhayay, Pratiti

“…Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the…”
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Intensive Multimodality Treatment for Children With Newly Diagnosed CNS Atypical Teratoid Rhabdoid Tumor by CHI, Susan N, ZIMMERMAN, Mary Ann, GOLDMAN, Stewart, MANLEY, Peter E, BOWERS, Daniel C, BENDEL, Anne, RUBIN, Joshua, TURNER, Christopher D, MARCUS, Karen J, GOUMNEROVA, Liliana, ULLRICH, Nicole J, KIERAN, Mark W, XIAOPAN YAO, COHEN, Kenneth J, BURGER, Peter, BIEGEL, Jaclyn A, RORKE-ADAMS, Lucy B, FISHER, Michael J, JANSS, Anna, MAZEWSKI, Claire

“…Atypical teratoid rhabdoid tumor (ATRT) of the CNS is a highly malignant neoplasm primarily affecting young children, with a historic median survival ranging…”
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Classification of treatment-related mortality in children with cancer: a systematic assessment by Alexander, Sarah, MD, Pole, Jason D, PhD, Gibson, Paul, MD, Lee, Michelle, MPH, Hesser, Tanya, MSW, Chi, Susan N, MD, Dvorak, Christopher C, MD, Fisher, Brian, DO, Hasle, Henrik, MD, Kanerva, Jukka, MD, Möricke, Anja, MD, Phillips, Bob, MD, Raetz, Elizabeth, MD, Rodriguez-Galindo, Carlos, MD, Samarasinghe, Sujith, PhD, Schmiegelow, Kjeld, MD, Tissing, Wim, MD, Lehrnbecher, Thomas, MD, Sung, Lillian, Dr

“…Summary Treatment-related mortality is an important outcome in paediatric cancer clinical trials. An international group of experts in supportive care in…”
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Lack of Efficacy of Bevacizumab Plus Irinotecan in Children With Recurrent Malignant Glioma and Diffuse Brainstem Glioma: A Pediatric Brain Tumor Consortium Study by GURURANGAN, Sridharan, CHI, Susan N, KUN, Larry E, POUSSAINT, Tina Young, ONAR-THOMAS, Arzu, GILBERTSON, Richard J, VAJAPEYAM, Sridhar, FRIEDMAN, Henry S, PACKER, Roger J, ROOD, Brian N, BOYETT, James M

“…A phase II study of bevacizumab (BVZ) plus irinotecan (CPT-11) was conducted in children with recurrent malignant glioma (MG) and intrinsic brainstem glioma…”
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A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low‐grade glioma by Wright, Karen D., Yao, Xiaopan, London, Wendy B., Kao, Pei‐Chi, Gore, Lia, Hunger, Stephen, Geyer, Russ, Cohen, Kenneth J., Allen, Jeffrey C., Katzenstein, Howard M., Smith, Amy, Boklan, Jessica, Nazemi, Kellie, Trippett, Tanya, Karajannis, Matthias, Herzog, Cynthia, Destefano, Joseph, Direnzo, Jennifer, Pietrantonio, Jay, Greenspan, Lianne, Cassidy, Danielle, Schissel, Debra, Perentesis, John, Basu, Mitali, Mizuno, Tomoyuki, Vinks, Alexander A., Prabhu, Sanjay P., Chi, Susan N., Kieran, Mark W.

“…Background To evaluate efficacy, pharmacokinetics (PK) and pharmacodynamics of single‐agent everolimus in pediatric patients with radiographically progressive…”
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Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma by Mueller, Sabine, Taitt, Jared M, Villanueva-Meyer, Javier E, Bonner, Erin R, Nejo, Takahide, Lulla, Rishi R, Goldman, Stewart, Banerjee, Anu, Chi, Susan N, Whipple, Nicholas S, Crawford, John R, Gauvain, Karen, Nazemi, Kellie J, Watchmaker, Payal B, Almeida, Neil D, Okada, Kaori, Salazar, Andres M, Gilbert, Ryan D, Nazarian, Javad, Molinaro, Annette M, Butterfield, Lisa H, Prados, Michael D, Okada, Hideho

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Off‐label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center by Gikandi, Ajami, Chi, Susan N., Yeo, Kee Kiat, O'Neill, Allison F., Shulman, David S., DuBois, Steven G., Collins, Natalie B.

“…Background Immune checkpoint inhibitors (ICI) have improved outcomes in a variety of adult cancers and are prescribed with increasing frequency across…”
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Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors by Kieran, Mark W., Roberts, Charles W.M., Chi, Susan N., Ligon, Keith L., Rich, Benjamin E., MacConaill, Laura E., Garraway, Levi A., Biegel, Jaclyn A.

“…Background Rhabdoid tumors (also called atypical teratoid/rhabdoid tumor (AT/RT) in the brain), are highly malignant, poor prognosis lesions arising in the…”
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Brain Tumors in Children by Fleming, Adam J., MD, Chi, Susan N., MD

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Feasibility and Response to Induction Chemotherapy Intensified With High-Dose Methotrexate for Young Children With Newly Diagnosed High-Risk Disseminated Medulloblastoma by CHI, Susan N, GARDNER, Sharon L, LEVY, Adam S, KNOPP, Edmond A, MILLER, Douglas C, WISOFF, Jeffrey H, WEINER, Howard L, FINLAY, Jonathan L

“…To evaluate the feasibility of and response rate to an intensified induction chemotherapy regimen for young children with newly diagnosed high-risk or…”
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Retrospective evaluation of single patient investigational new drug (IND) requests in pediatric oncology by Shulman, David S., Kiwinda, Lulla V., Edwards, Stacey, Clinton, Catherine M., Hunt, Sarah, Greenspan, Lianne, Lawler, Kristen D., Reaman, Gregory, Al‐Sayegh, Hasan, Bona, Kira, O'Neill, Allison F., Shusterman, Suzanne, Janeway, Katherine A., Place, Andrew E., Chi, Susan N., Ma, Clement, DuBois, Steven G.

“…Background Single patient Investigational New Drug (IND) applications are one mechanism through which experimental therapies are accessed for children with…”
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The challenges in treating embryonal tumors with multilayered rosettes (ETMR) and other infant brain tumors by Bandopadhayay, Pratiti, Chi, Susan N

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Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma by Manoharan, Neevika, Choi, Jungwhan, Chordas, Christine, Zimmerman, Mary Ann, Scully, Jacqueline, Clymer, Jessica, Filbin, Mariella, Ullrich, Nicole J., Bandopadhayay, Pratiti, Chi, Susan N., Yeo, Kee Kiat

“…Purpose Pediatric low-grade gliomas (pLGGs) are the most common CNS tumor of childhood and comprise a heterogenous group of tumors. Children with progressive…”
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Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma by Mueller, Sabine, Taitt, Jared M, Villanueva-Meyer, Javier E, Bonner, Erin R, Nejo, Takahide, Lulla, Rishi R, Goldman, Stewart, Banerjee, Anu, Chi, Susan N, Whipple, Nicholas S, Crawford, John R, Gauvain, Karen, Nazemi, Kellie J, Watchmaker, Payal B, Almeida, Neil D, Okada, Kaori, Salazar, Andres M, Gilbert, Ryan D, Nazarian, Javad, Molinaro, Annette M, Butterfield, Lisa H, Prados, Michael D, Okada, Hideho

“…BACKGROUNDPatients with diffuse midline gliomas (DMGs), including diffuse intrinsic pontine glioma (DIPG), have dismal outcomes. We previously described the…”
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A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors by Geoerger, Birgit, Bourdeaut, Franck, DuBois, Steven G, Fischer, Matthias, Geller, James I, Gottardo, Nicholas G, Marabelle, Aurélien, Pearson, Andrew D J, Modak, Shakeel, Cash, Thomas, Robinson, Giles W, Motta, Marlyane, Matano, Alessandro, Bhansali, Suraj G, Dobson, Jason R, Parasuraman, Sudha, Chi, Susan N

“…The cyclin-dependent kinase (CDK) 4/6 inhibitor, ribociclib (LEE011), displayed preclinical activity in neuroblastoma and malignant rhabdoid tumor (MRT)…”
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Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: An analysis of the Surveillance Epidemiology and End Results (SEER) database by Bandopadhayay, Pratiti, Bergthold, Guillaume, London, Wendy B., Goumnerova, Liliana C., Morales La Madrid, Andres, Marcus, Karen J., Guo, Dongjing, Ullrich, Nicole J., Robison, Nathan J., Chi, Susan N., Beroukhim, Rameen, Kieran, Mark W., Manley, Peter E.

“…Background Children with pediatric low‐grade gliomas (PLGG) are known to have excellent 10‐year survival rates; however the outcomes of adult survivors of PLGG…”
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Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C by Chi, Susan N, Yi, Joanna S, Williams, P Mickey, Roy-Chowdhuri, Sinchita, Patton, David R, Coffey, Brent D, Reid, Joel M, Piao, Jin, Saguilig, Lauren, Alonzo, Todd A, Berg, Stacey L, Ramirez, Nilsa C, Jaju, Alok, Mhlanga, Joyce C, Fox, Elizabeth, Hawkins, Douglas S, Mooney, Margaret M, Takebe, Naoko, Tricoli, James V, Janeway, Katherine A, Seibel, Nita L, Parsons, D Williams

“…Abstract Background National Cancer Institute-Children’s Oncology Group Pediatric Molecular Analysis for Therapy Choice assigns patients aged 1-21 years with…”
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The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial by Kilburn, Lindsay B., Khuong-Quang, Dong-Anh, Hansford, Jordan R., Landi, Daniel, van der Lugt, Jasper, Leary, Sarah E. S., Driever, Pablo Hernáiz, Bailey, Simon, Perreault, Sébastien, McCowage, Geoffrey, Waanders, Angela J., Ziegler, David S., Witt, Olaf, Baxter, Patricia A., Kang, Hyoung Jin, Hassall, Timothy E., Han, Jung Woo, Hargrave, Darren, Franson, Andrea T., Yalon Oren, Michal, Toledano, Helen, Larouche, Valérie, Kline, Cassie, Abdelbaki, Mohamed S., Jabado, Nada, Gottardo, Nicholas G., Gerber, Nicolas U., Whipple, Nicholas S., Segal, Devorah, Chi, Susan N., Oren, Liat, Tan, Enrica E. K., Mueller, Sabine, Cornelio, Izzy, McLeod, Lisa, Zhao, Xin, Walter, Ashley, Da Costa, Daniel, Manley, Peter, Blackman, Samuel C., Packer, Roger J., Nysom, Karsten

“…BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade glioma (pLGG). Arm 1 ( n  = 77) of the ongoing phase 2 FIREFLY-1…”
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