Search Results - "Chi, Neil"

Coordinating the first heartbeat by Bloomekatz, Joshua, Chi, Neil C.

“…An impressive combination of computational modelling and experimental techniques in live zebrafish embryos reveals how the heart initiates its organized and…”
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Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA by Yoshioka, Naohisa, Gros, Edwige, Li, Hai-Ri, Kumar, Shantanu, Deacon, Dekker C., Maron, Cornelia, Muotri, Alysson R., Chi, Neil C., Fu, Xiang-Dong, Yu, Benjamin D., Dowdy, Steven F.

“…The generation of human induced pluripotent stem cells (iPSCs) holds great promise for the development of regenerative medicine therapies to treat a wide range…”
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Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells by Zhang, Yanxiao, Li, Ting, Preissl, Sebastian, Amaral, Maria Luisa, Grinstein, Jonathan D., Farah, Elie N., Destici, Eugin, Qiu, Yunjiang, Hu, Rong, Lee, Ah Young, Chee, Sora, Ma, Kaiyue, Ye, Zhen, Zhu, Quan, Huang, Hui, Fang, Rongxin, Yu, Leqian, Izpisua Belmonte, Juan Carlos, Wu, Jun, Evans, Sylvia M., Chi, Neil C., Ren, Bing

“…Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully…”
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Haematopoietic stem cells derive directly from aortic endothelium during development by Teng, Shutian, Santoso, Buyung, Traver, David, Bertrand, Julien Y, Chi, Neil C, Stainier, Didier Y. R

“…A major goal of regenerative medicine is to instruct formation of multipotent, tissue-specific stem cells from induced pluripotent stem cells (iPSCs) for cell…”
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Unveiling Complexity and Multipotentiality of Early Heart Fields by Zhang, Qingquan, Carlin, Daniel, Zhu, Fugui, Cattaneo, Paola, Ideker, Trey, Evans, Sylvia M., Bloomekatz, Joshua, Chi, Neil C.

“…[Figure: see text]…”
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Fishing Out the Role of RBPMS2 in Cardiac Splicing by Holman, Alyssa R., Chi, Neil C.

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Zebrafish models in cardiac development and congenital heart birth defects by Tu, Shu, Chi, Neil C.

“…The zebrafish has become an ideal vertebrate animal system for investigating cardiac development due to its genetic tractability, external fertilization, early…”
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In vivo cardiac reprogramming contributes to zebrafish heart regeneration by Zhang, Ruilin, Han, Peidong, Yang, Hongbo, Ouyang, Kunfu, Lee, Derek, Lin, Yi-Fan, Ocorr, Karen, Kang, Guson, Chen, Ju, Stainier, Didier Y. R., Yelon, Deborah, Chi, Neil C.

“…A cardiac injury study in zebrafish reveals the plasticity of heart cell lineages as shown by a Notch-dependent transdifferentiation of atrial to ventricular…”
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Integrative analysis of haplotype-resolved epigenomes across human tissues by Leung, Danny, Jung, Inkyung, Rajagopal, Nisha, Schmitt, Anthony, Selvaraj, Siddarth, Lee, Ah Young, Yen, Chia-An, Lin, Shin, Lin, Yiing, Qiu, Yunjiang, Xie, Wei, Yue, Feng, Hariharan, Manoj, Ray, Pradipta, Kuan, Samantha, Edsall, Lee, Yang, Hongbo, Chi, Neil C., Zhang, Michael Q., Ecker, Joseph R., Ren, Bing

“…As part of the Epigenome Roadmap project, this study uses a chromosome-spanning haplotype reconstruction strategy to construct haplotype-resolved epigenomic…”
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Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome by Guemez-Gamboa, Alicia, Nguyen, Long N, Yang, Hongbo, Zaki, Maha S, Kara, Majdi, Ben-Omran, Tawfeg, Akizu, Naiara, Rosti, Rasim Ozgur, Rosti, Basak, Scott, Eric, Schroth, Jana, Copeland, Brett, Vaux, Keith K, Cazenave-Gassiot, Amaury, Quek, Debra Q Y, Wong, Bernice H, Tan, Bryan C, Wenk, Markus R, Gunel, Murat, Gabriel, Stacey, Chi, Neil C, Silver, David L, Gleeson, Joseph G

“…Joseph Gleeson, David Silver and colleagues show that inactivating mutations in MFSD2A , which encodes an essential transporter of long-chain fatty acids in…”
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Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis by Han, Peidong, Bloomekatz, Joshua, Ren, Jie, Zhang, Ruilin, Grinstein, Jonathan D., Zhao, Long, Burns, C. Geoffrey, Burns, Caroline E., Anderson, Ryan M., Chi, Neil C.

“…A complex interplay involving Notch- and Erbb2-mediated signalling between cardiomyocytes guides the morphogenesis of the ventricular wall. Many organs are…”
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Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly by Li, Hongda, Bielas, Stephanie L., Zaki, Maha S., Ismail, Samira, Farfara, Dorit, Um, Kyongmi, Rosti, Rasim O., Scott, Eric C., Tu, Shu, Chi, Neil C., Gabriel, Stacey, Erson-Omay, Emine Z., Ercan-Sencicek, A. Gulhan, Yasuno, Katsuhito, Çağlayan, Ahmet Okay, Kaymakçalan, Hande, Ekici, Barış, Bilguvar, Kaya, Gunel, Murat, Gleeson, Joseph G.

“…Cell division terminates with cytokinesis and cellular separation. Autosomal-recessive primary microcephaly (MCPH) is a neurodevelopmental disorder…”
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Cardiac Morphogenesis: Crowding and Tension Resolved through Social Distancing by Bloomekatz, Joshua, Diaz, Jessyka T., Yelon, Deborah, Chi, Neil C.

“…Organ maturation entails the reshaping of simple tissues into more complex structures critical for function. In a recent issue of Nature, Priya et al. show how…”
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ccbe1 is required for embryonic lymphangiogenesis and venous sprouting by Schulte-Merker, Stefan, Hogan, Benjamin M, Bos, Frank L, Bussmann, Jeroen, Witte, Merlijn, Chi, Neil C, Duckers, Henricus J

“…Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called…”
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Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes by Ren, Jie, Han, Peidong, Ma, Xuanyi, Farah, Elie N., Bloomekatz, Joshua, Zeng, Xin-Xin I., Zhang, Ruilin, Swim, Megan M., Witty, Alec D., Knight, Hannah G., Deshpande, Rima, Xu, Weizhe, Yelon, Deborah, Chen, Shaochen, Chi, Neil C.

“…Pacemaker cardiomyocytes that create the sinoatrial node are essential for the initiation and maintenance of proper heart rhythm. However, illuminating…”
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Genetic and physiologic dissection of the vertebrate cardiac conduction system by Chi, Neil C, Shaw, Robin M, Jungblut, Benno, Huisken, Jan, Ferrer, Tania, Arnaout, Rima, Scott, Ian, Beis, Dimitris, Xiao, Tong, Baier, Herwig, Jan, Lily Y, Tristani-Firouzi, Martin, Stainier, Didier Y R

“…Vertebrate hearts depend on highly specialized cardiomyocytes that form the cardiac conduction system (CCS) to coordinate chamber contraction and drive blood…”
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Myocardial plasticity: cardiac development, regeneration and disease by Bloomekatz, Joshua, Galvez-Santisteban, Manuel, Chi, Neil C

“…The adult mammalian heart is unable to recover from myocardial cell loss due to cardiac ischemia and infarction because terminally differentiated…”
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An evolutionarily conserved program of B-cell development and activation in zebrafish by Page, Dawne M., Wittamer, Valerie, Bertrand, Julien Y., Lewis, Kanako L., Pratt, David N., Delgado, Noemi, Schale, Sarah E., McGue, Caitlyn, Jacobsen, Bradley H., Doty, Alyssa, Pao, Yvonne, Yang, Hongbo, Chi, Neil C., Magor, Brad G., Traver, David

“…Teleost fish are among the most ancient vertebrates possessing an adaptive immune system with B and T lymphocytes that produce memory responses to pathogens…”
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Foxn4 directly regulates tbx2b expression and atrioventricular canal formation by Chi, Neil C, Shaw, Robin M, De Val, Sarah, Kang, Guson, Jan, Lily Y, Black, Brian L, Stainier, Didier Y R

“…Cardiac chamber formation represents an essential evolutionary milestone that allows for the heart to receive (atrium) and pump (ventricle) blood throughout a…”
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Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells by Xie, Wei, Schultz, Matthew D., Lister, Ryan, Hou, Zhonggang, Rajagopal, Nisha, Ray, Pradipta, Whitaker, John W., Tian, Shulan, Hawkins, R. David, Leung, Danny, Yang, Hongbo, Wang, Tao, Lee, Ah Young, Swanson, Scott A., Zhang, Jiuchun, Zhu, Yun, Kim, Audrey, Nery, Joseph R., Urich, Mark A., Kuan, Samantha, Yen, Chia-an, Klugman, Sarit, Yu, Pengzhi, Suknuntha, Kran, Propson, Nicholas E., Chen, Huaming, Edsall, Lee E., Wagner, Ulrich, Li, Yan, Ye, Zhen, Kulkarni, Ashwinikumar, Xuan, Zhenyu, Chung, Wen-Yu, Chi, Neil C., Antosiewicz-Bourget, Jessica E., Slukvin, Igor, Stewart, Ron, Zhang, Michael Q., Wang, Wei, Thomson, James A., Ecker, Joseph R., Ren, Bing

“…Epigenetic mechanisms have been proposed to play crucial roles in mammalian development, but their precise functions are only partially understood. To…”
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