Search Results - "Chhina, Jasdeep"
-
1
Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
Published in Scientific reports (18-08-2017)“…Earlier investigations have revealed that tumor cells undergo metabolic reprogramming and mainly derive their cellular energy from aerobic glycolysis rather…”
Get full text
Journal Article -
2
Risk of ESRD and Mortality in Kidney and Bladder Stone Formers
Published in American journal of kidney diseases (01-12-2018)“…[Display omitted] Kidney stones have been associated with increased risk for end-stage renal disease (ESRD). However, it is unclear whether there is also an…”
Get full text
Journal Article -
3
Folic acid tagged nanoceria as a novel therapeutic agent in ovarian cancer
Published in BMC cancer (15-03-2016)“…Nanomedicine is a very promising field and nanomedical drugs have recently been used as therapeutic agents against cancer. In a previous study, we showed that…”
Get full text
Journal Article -
4
Metformin limits the adipocyte tumor-promoting effect on ovarian cancer
Published in Oncotarget (15-07-2014)“…Omental adipocytes promote ovarian cancer by secretion of adipokines, cytokines and growth factors, and acting as fuel depots. We investigated if metformin…”
Get full text
Journal Article -
5
Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer
Published in Gynecologic oncology (01-08-2017)“…•Metformin inhibits LGSOC cells.•Trametinib inhibits LGSOC with RAS mutation.•Synergistic effect of Metformin and Trametinib depends on RAS…”
Get full text
Journal Article -
6
Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence
Published in Gynecologic oncology (01-04-2016)“…Abstract Objectives Adipocyte derived free fatty acids (FFA) promote epithelial ovarian cancer (EOC) by acting as a fuel source to support the energy…”
Get full text
Journal Article -
7
Abstract 11: Metformin exerts differential metabolic effects in ovarian cancer cell lines
Published in Cancer research (Chicago, Ill.) (15-07-2016)“…Metformin is being actively repurposed for treatment of gynecologic malignancies including ovarian cancer, with various clinical trials underway. Metformin is…”
Get full text
Journal Article -
8
Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction
Published in Oncotarget (10-05-2015)“…Caloric restriction (CR) was recently demonstrated by us to restrict ovarian cancer growth in vivo. CR resulted in activation of energy regulating enzymes…”
Get full text
Journal Article -
9
Abstract A81: Targeting of free fatty acid signaling in ovarian cancer may serve as a potential therapeutic approach
Published in Clinical cancer research (15-01-2016)“…Recent studies have revealed an association between adipocyte driven free fatty acids (FFA) and the aggressiveness of epithelial ovarian cancer (EOC)…”
Get full text
Journal Article -
10
Dietary energy balance modulates ovarian cancer progression and metastasis
Published in Oncotarget (15-08-2014)“…A high energy balance, or caloric excess, accounts as a tumor promoting factor, while a negative energy balance via caloric restriction, has been shown to…”
Get full text
Journal Article -
11
Abstract B77: Targeting ovarian cancer promoting effects of adipocytes by metformin
Published in Clinical cancer research (01-10-2013)“…At the time of surgery, 80% of the ovarian cancers are found to be metastasized to the omentum, a large fat pad covering the abdominal organs. Omental…”
Get full text
Journal Article