Search Results - "Chhatwal, Gursharan S."

Anchorless adhesins and invasins of Gram-positive bacteria: a new class of virulence factors by Chhatwal, Gursharan S

“…Bacterial adherence to and invasion of eukaryotic cells are important mechanisms of pathogenicity. Most Gram-positive bacteria interact with the components of…”
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Virulence Gene Pool Detected in Bovine Group C Streptococcus dysgalactiae subsp. dysgalactiae Isolates by Use of a Group A S. pyogenes Virulence Microarray by RATO, Marcia G, NERLICH, Andreas, BERGMANN, Rene, BEXIGA, Ricardo, NUNES, Sandro F, VILELA, Cristina L, SANTOS-SANCHES, Ilda, CHHATWAL, Gursharan S

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The Group A Streptococcus Interleukin-8 Protease SpyCEP Promotes Bacterial Intracellular Survival by Evasion of Autophagy by Bergmann, René, Gulotta, Giuseppe, Andreoni, Federica, Sumitomo, Tomoko, Kawabata, Shigetada, Zinkernagel, Annelies S., Chhatwal, Gursharan S., Nizet, Victor, Rohde, Manfred, Uchiyama, Satoshi

“…Autophagy serves an innate immune function in defending the host against invading bacteria, including group A (GAS). Autophagy is regulated by numerous host…”
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Contribution of Streptococcus anginosus to infections caused by groups C and G streptococci, southern India by Reissmann, Silvana, Friedrichs, Claudia, Rajkumari, Reena, Itzek, Andreas, Fulde, Marcus, Rodloff, Arne C, Brahmadathan, Kootallur N, Chhatwal, Gursharan S, Nitsche-Schmitz, D Patric

“…Vellore, a region in southern India, has a high incidence of severe human infections with Beta-hemolytic group C and G streptococci (GCGS). To determine the…”
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Transcriptome Analysis of Murine Macrophages in Response to Infection with Streptococcus pyogenes Reveals an Unusual Activation Program by Goldmann, Oliver, von Köckritz-Blickwede, Maren, Höltje, Claudia, Chhatwal, Gursharan S, Geffers, Robert, Medina, Eva

“…The complex response of murine macrophages to infection with Streptococcus pyogenes was investigated at the level of gene expression with a high-density…”
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Microevolution of group A streptococci in vivo: capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence by Aziz, Ramy K, Kansal, Rita, Aronow, Bruce J, Taylor, William L, Rowe, Sarah L, Kubal, Michael, Chhatwal, Gursharan S, Walker, Mark J, Kotb, Malak

“…The onset of infection and the switch from primary to secondary niches are dramatic environmental changes that not only alter bacterial transcriptional…”
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Invasion mechanisms of Gram-positive pathogenic cocci by Nitsche-Schmitz, D Patric, Rohde, Manfred, Chhatwal, Gursharan S

“…Gram-positive cocci are important human pathogens. Streptococci and staphylococci in particular are a major threat to human health, since they cause a variety…”
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More than One Tandem Repeat Domain of the Extracellular Adherence Protein of Staphylococcus aureus Is Required for Aggregation, Adherence, and Host Cell Invasion but Not for Leukocyte Activation by Hussain, Muzaffar, Haggar, Axana, Peters, Georg, Chhatwal, Gursharan S, Herrmann, Mathias, Flock, Jan-Ingmar, Sinha, Bhanu

“…The extracellular adherence protein (Eap) is a multifunctional Staphylococcus aureus protein and broad-spectrum adhesin for several host matrix and plasma…”
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Contribution of plasminogen activation towards the pathogenic potential of oral streptococci by Itzek, Andreas, Gillen, Christine M, Fulde, Marcus, Friedrichs, Claudia, Rodloff, Arne C, Chhatwal, Gursharan S, Nitsche-Schmitz, Daniel Patric

“…Oral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to…”
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Crucial role of the CB3-region of collagen IV in PARF-induced acute rheumatic fever by Dinkla, Katrin, Talay, Susanne R, Mörgelin, Matthias, Graham, Rikki M A, Rohde, Manfred, Nitsche-Schmitz, D Patric, Chhatwal, Gursharan S

“…Acute rheumatic fever (ARF) and rheumatic heart disease are serious autoimmune sequelae to infections with Streptococcus pyogenes. Streptococcal M-proteins…”
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Invasion of Endothelial Cells by Tissue-invasive M3 Type Group A Streptococci Requires Src Kinase and Activation of Rac1 by a Phosphatidylinositol 3-Kinase-independent Mechanism by Nerlich, Andreas, Rohde, Manfred, Talay, Susanne R., Genth, Harald, Just, Ingo, Chhatwal, Gursharan S.

“…Streptococcus pyogenes can cause invasive diseases in humans, such as sepsis or necrotizing fasciitis. Among the various M serotypes of group A streptococci…”
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Identification of a Streptococcal Octapeptide Motif Involved in Acute Rheumatic Fever by Dinkla, Katrin, Nitsche-Schmitz, D. Patric, Barroso, Vanessa, Reissmann, Silvana, Johansson, Helena M., Frick, Inga-Maria, Rohde, Manfred, Chhatwal, Gursharan S.

“…Acute rheumatic fever is a serious autoimmune sequela of pharyngitis caused by certain group A streptococci. One mechanism applied by streptococcal strains…”
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Region specific and worldwide distribution of collagen-binding M proteins with PARF motifs among human pathogenic streptococcal isolates by Reissmann, Silvana, Gillen, Christine M, Fulde, Marcus, Bergmann, René, Nerlich, Andreas, Rajkumari, Reena, Brahmadathan, Kootallur N, Chhatwal, Gursharan S, Nitsche-Schmitz, D Patric

“…Some of the variety of Streptococcus pyogenes and Streptococcus dysgalactiae ssp. equisimilis (SDSE) M proteins act as collagen-binding adhesins that…”
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The Contribution of Dendritic Cells to Host Defenses against Streptococcus pyogenes by Loof, Torsten G., Rohde, Manfred, Chhatwal, Gursharan S., Jung, Steffen, Medina, Eva

“…Background. Infection with Streptococcus pyogenes remains a significant health care problem. The identification of immune components required for host defenses…”
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Differences in the aromatic domain of homologous streptococcal fibronectin-binding proteins trigger different cell invasion mechanisms and survival rates by Rohde, Manfred, Graham, Rikki M, Branitzki-Heinemann, Katja, Borchers, Patricia, Preuss, Claudia, Schleicher, Ina, Zähner, Dorothea, Talay, Susanne R, Fulde, Marcus, Dinkla, Katrin, Chhatwal, Gursharan S

“…Group A streptococci (GAS, Streptococcus pyogenes) and Group G streptococci (GGS, Streptococcus dysgalactiae ssp. equisimilis) adhere to and invade host cells…”
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Intracellular Survival of Streptococcus pyogenes in Polymorphonuclear Cells Results in Increased Bacterial Virulence by MEDINA, Eva, ROHDE, Manfred, CHHATWAL, Gursharan S

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Variability in the Distribution of Genes Encoding Virulence Factors and Putative Extracellular Proteins of Streptococcus pyogenes in India, a Region with High Streptococcal Disease Burden, and Implication for Development of a Regional Multisubunit Vaccine by Sagar, Vivek, Bergmann, René, Nerlich, Andreas, McMillan, David J, Nitsche Schmitz, D Patric, Chhatwal, Gursharan S

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Contribution of Natural Killer Cells to the Pathogenesis of Septic Shock Induced by Streptococcus pyogenes in Mice by Goldmann, Oliver, Chhatwal, Gursharan S., Medina, Eva

“…Natural killer (NK) cells are critical components of the innate immune system and have been implicated in the pathogenesis of septic shock. In the present…”
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Ectodomains 3 and 4 of Human Polymeric Immunoglobulin Receptor (hpIgR) Mediate Invasion of Streptococcus pneumoniae into the Epithelium by Elm, Christine, Braathen, Ranveig, Bergmann, Simone, Frank, Ronald, Vaerman, Jean-Pierre, Kaetzel, Charlotte S., Chhatwal, Gursharan S., Johansen, Finn-Eirik, Hammerschmidt, Sven

“…Streptococcus pneumoniae binds to the ectodomain of the human polymeric Ig receptor (pIgR), also known as secretory component (SC), via a hexapeptide motif in…”
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Group G Streptococcal IgG Binding Molecules FOG and Protein G Have Different Impacts on Opsonization by C1q by Nitsche-Schmitz, D. Patric, Johansson, Helena M., Sastalla, Inka, Reissmann, Silvana, Frick, Inga-Maria, Chhatwal, Gursharan S.

“…Recent epidemiological data on diseases caused by β-hemolytic streptococci belonging to Lancefield group C and G (GCS, GGS) underline that they are an emerging…”
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