Search Results - "Chhatbar, Chintan"

The roles of microglia in viral encephalitis: from sensome to therapeutic targeting by Chhatbar, Chintan, Prinz, Marco

“…Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune…”
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From shape to contents: heterogeneity of CNS glial cells by Chhatbar, Chintan, Prinz, Marco

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Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage by Waltl, Inken, Käufer, Christopher, Gerhauser, Ingo, Chhatbar, Chintan, Ghita, Luca, Kalinke, Ulrich, Löscher, Wolfgang

“…•Microglia’s role in encephalitis and its long-term consequences is incompletely understood.•We studied consequences of microglia depletion in a picorna virus…”
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Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS by Hosseini, Shirin, Michaelsen-Preusse, Kristin, Grigoryan, Gayane, Chhatbar, Chintan, Kalinke, Ulrich, Korte, Martin

“…Type I interferon receptor (IFNAR) signaling is a hallmark of viral control and host protection. Here, we show that, in the hippocampus of healthy…”
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DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress by Hersperger, Fabian, Meyring, Tim, Weber, Pia, Chhatbar, Chintan, Monaco, Gianni, Dionne, Marc S, Paeschke, Katrin, Prinz, Marco, Groß, Olaf, Classen, Anne-Kathrin, Kierdorf, Katrin

“…Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades,…”
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Innate immune sensing of danger signals: novel mechanism of heme complex-mediated lytic cell death by Chhatbar, Chintan, Schulz, Michael, Sankowski, Roman

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Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis by Borst, Katharina, Frenz, Theresa, Spanier, Julia, Tegtmeyer, Pia-Katharina, Chhatbar, Chintan, Skerra, Jennifer, Ghita, Luca, Namineni, Sukumar, Lienenklaus, Stefan, Köster, Mario, Heikenwaelder, Mathias, Sutter, Gerd, Kalinke, Ulrich

“…[Display omitted] •During acute viral hepatitis local IFN-I responses modulate liver inflammation.•IFNAR triggering of Kupffer cells protects against liver…”
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Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis by Waltl, Inken, Käufer, Christopher, Bröer, Sonja, Chhatbar, Chintan, Ghita, Luca, Gerhauser, Ingo, Anjum, Muneeb, Kalinke, Ulrich, Löscher, Wolfgang

“…Viral encephalitis is a major risk factor for the development of seizures and epilepsy, but the underlying mechanisms are only poorly understood. Mouse models…”
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Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis by Chhatbar, Chintan, Detje, Claudia N., Grabski, Elena, Borst, Katharina, Spanier, Julia, Ghita, Luca, Elliott, David A., Jordão, Marta Joana Costa, Mueller, Nora, Sutton, James, Prajeeth, Chittappen K., Gudi, Viktoria, Klein, Michael A., Prinz, Marco, Bradke, Frank, Stangel, Martin, Kalinke, Ulrich

“…In sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses…”
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The olfactory epithelium as a port of entry in neonatal neurolisteriosis by Pägelow, Dennis, Chhatbar, Chintan, Beineke, Andreas, Liu, Xiaokun, Nerlich, Andreas, van Vorst, Kira, Rohde, Manfred, Kalinke, Ulrich, Förster, Reinhold, Halle, Stephan, Valentin-Weigand, Peter, Hornef, Mathias W., Fulde, Marcus

“…Bacterial infections of the central nervous system (CNS) remain a major cause of mortality in the neonatal population. Commonly used parenteral infection…”
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HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia by Mishra, Ritu, Chhatbar, Chintan, Singh, Sunit Kumar

“…HIV-1 Tat protein is known to be associated with neuroinflammation, a condition that develops in almost half of patients infected with HIV-1. HIV-1 Tat can…”
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Anti-PD-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation by Vinnakota, Janaki Manoja, Adams, Rachael C, Athanassopoulos, Dimitrios, Schmidt, Dominik, Biavasco, Francesca, Zähringer, Alexander, Erny, Daniel, Schwabenland, Marius, Langenbach, Marlene, Wenger, Valentin, Salié, Henrike, Cook, James, Mossad, Omar, Andrieux, Geoffroy, Dersch, Rick, Rauer, Sebastian, Duquesne, Sandra, Monaco, Gianni, Wolf, Phillipp, Blank, Thomas, Häne, Philipp, Greter, Melanie, Becher, Burkhard, Henneke, Philipp, Pfeifer, Dietmar, Blazar, Bruce R, Duyster, Justus, Boerries, Melanie, Köhler, Natalie, Chhatbar, Chintan M, Bengsch, Bertram, Prinz, Marco, Zeiser, Robert

“…Cancer treatment with anti-PD-1 immunotherapy can cause central nervous system immune-related adverse events (CNS-irAEs). The role of microglia in anti-PD-1…”
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Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection by Borst, Katharina, Flindt, Sven, Blank, Patrick, Larsen, Pia-Katharina, Chhatbar, Chintan, Skerra, Jennifer, Spanier, Julia, Hirche, Christoph, König, Martin, Alanentalo, Tomas, Hafner, Martin, Waibler, Zoe, Pfeffer, Klaus, Sexl, Veronika, Sutter, Gerd, Müller, Werner, Graalmann, Theresa, Kalinke, Ulrich

“…IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and…”
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Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo by Hirche, Christoph, Frenz, Theresa, Haas, Simon F., Döring, Marius, Borst, Katharina, Tegtmeyer, Pia-K., Brizic, Ilija, Jordan, Stefan, Keyser, Kirsten, Chhatbar, Chintan, Pronk, Eline, Lin, Shuiping, Messerle, Martin, Jonjic, Stipan, Falk, Christine S., Trumpp, Andreas, Essers, Marieke A.G., Kalinke, Ulrich

“…Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). However, this effect remains poorly investigated…”
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Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures by Käufer, Christopher, Chhatbar, Chintan, Bröer, Sonja, Waltl, Inken, Ghita, Luca, Gerhauser, Ingo, Kalinke, Ulrich, Löscher, Wolfgang

“…Viral encephalitis is a major risk factor for the development of seizures, epilepsy, and hippocampal damage with associated cognitive impairment, markedly…”
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Multiomic spatial landscape of innate immune cells at human central nervous system borders by Sankowski, Roman, Süß, Patrick, Benkendorff, Alexander, Böttcher, Chotima, Fernandez-Zapata, Camila, Chhatbar, Chintan, Cahueau, Jonathan, Monaco, Gianni, Gasull, Adrià Dalmau, Khavaran, Ashkan, Grauvogel, Jürgen, Scheiwe, Christian, Shah, Mukesch Johannes, Heiland, Dieter Henrik, Schnell, Oliver, Markfeld-Erol, Filiz, Kunze, Mirjam, Zeiser, Robert, Priller, Josef, Prinz, Marco

“…The innate immune compartment of the human central nervous system (CNS) is highly diverse and includes several immune-cell populations such as macrophages that…”
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Brain endothelial STING1 activation by Plasmodium -sequestered heme promotes cerebral malaria via type I IFN response by Pais, Teresa F., Ali, Hajrabibi, Moreira da Silva, Joana, Duarte, Nádia, Neres, Rita, Chhatbar, Chintan, Acúrcio, Rita C., Guedes, Rita C., Strano Moraes, Maria Carolina, Costa-Silva, Bruno, Kalinke, Ulrich, Penha-Gonçalves, Carlos

“…Cerebral malaria (CM) is a life-threatening form of Plasmodium falciparum infection caused by brain inflammation. Brain endothelium dysfunction is a hallmark…”
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Japanese encephalitis virus: from genome to infectome by Unni, Salini Krishnan, Růžek, Daniel, Chhatbar, Chintan, Mishra, Ritu, Johri, Manish K., Singh, Sunit K.

“…Japanese encephalitis virus (JEV) is an arbovirus belonging to the family Flaviviridae. It is maintained in a zoonotic cycle involving pigs, ardeid birds and…”
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DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress by Hersperger, Fabian, Meyring, Tim, Weber, Pia, Chhatbar, Chintan, Monaco, Gianni, Dionne, Marc S, Paeschke, Katrin, Prinz, Marco, Groß, Olaf, Classen, Anne-Kathrin, Kierdorf, Katrin

“…Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades,…”
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Upon intranasal vesicular stomatitis virus infection, astrocytes in the olfactory bulb are important interferon Beta producers that protect from lethal encephalitis by Detje, Claudia N, Lienenklaus, Stefan, Chhatbar, Chintan, Spanier, Julia, Prajeeth, Chittappen K, Soldner, Claudia, Tovey, Michael G, Schlüter, Dirk, Weiss, Siegfried, Stangel, Martin, Kalinke, Ulrich

“…Previously we found that following intranasal (i.n.) infection with neurotropic vesicular stomatitis virus (VSV) type I interferon receptor (IFNAR) triggering…”
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