Search Results - "Chhangani, Deepak"

Molecular, functional, and pathological aspects of TDP-43 fragmentation by Chhangani, Deepak, Martín-Peña, Alfonso, Rincon-Limas, Diego E.

“…Transactive response DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in transcriptional regulation and RNA processing. It is linked to…”
Get full text

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity by Upadhyay, Arun, Chhangani, Deepak, Rao, Nalini R, Kofler, Julia, Vassar, Robert, Rincon-Limas, Diego E, Savas, Jeffrey N

“…The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer's disease (AD). Our understanding of the proteins that promote Aβ…”
Get full text

TDP-35, a truncated fragment of TDP-43, induces dose-dependent toxicity and apoptosis in flies by Chhangani, Deepak, Rincon-Limas, Diego

Get full text

Autophagy Coupling Interplay: Can Improve Cellular Repair and Aging? by Chhangani, Deepak, Chinchwadkar, Sachin, Mishra, Amit

“…Regular protein synthesis is a needful and complex task for a healthy cell. Improper folding leads to the deposition of misfolded proteins in cells. Autophagy…”
Get full text

E3 Ubiquitin Ligases in Protein Quality Control Mechanism by Chhangani, Deepak, Joshi, Ajay Prakash, Mishra, Amit

“…In living cells, polypeptide chains emerging from ribosomes and preexisting polypeptide chains face constant threat of misfolding and aggregation. To prevent…”
Get full text

Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model by Chhangani, Deepak, Endo, Fumito, Amanullah, Ayeman, Upadhyay, Arun, Watanabe, Seiji, Mishra, Ribhav, Yamanaka, Koji, Mishra, Amit

“…Abstract Proteotoxicity of misfolded, disease-causing proteins is deeply implicated in the pathomechanisms for neurodegenerative diseases including copper-zinc…”
Get full text

Mahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity by Chhangani, Deepak, Mishra, Amit

Get full text

secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids by De Mena, Lorena, Chhangani, Deepak, Fernandez-Funez, Pedro, Rincon-Limas, Diego E.

“…Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders. These aggregates are deposited…”
Get full text

Identification of potential pathways and biomarkers linked to progression in ALS by Huber, Roland G., Pandey, Swapnil, Chhangani, Deepak, Rincon‐Limas, Diego E., Staff, Nathan P., Yeo, Crystal Jing Jing

“…Objective To identify potential diagnostic and prognostic biomarkers for clinical management and clinical trials in amyotrophic lateral sclerosis. Methods We…”
Get full text

Misfolded Proteins Recognition Strategies of E3 Ubiquitin Ligases and Neurodegenerative Diseases by Chhangani, Deepak, Jana, Nihar Ranjan, Mishra, Amit

Get full text

Mahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity by Chhangani, Deepak, Mishra, Amit

“…Impairment in the elimination of misfolded proteins generates cellular toxicity and leads to various late-onset neurodegenerative diseases. However, the…”
Get full text

Protein Quality Control System in Neurodegeneration: A Healing Company Hard to Beat but Failure is Fatal by Chhangani, Deepak, Mishra, Amit

“…A common feature in most neurodegenerative diseases and aging is the progressive accumulation of damaged proteins. Proteins are essential for all crucial…”
Get full text

Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins by Chhangani, Deepak, Upadhyay, Arun, Amanullah, Ayeman, Joshi, Vibhuti, Mishra, Amit

“…The protein quality control (QC) system protects cells against cellular toxicity induced by misfolded proteins and maintains overall cellular fitness…”
Get full text

Misfolded Proteins Recognition Strategies of E3 Ubiquitin Ligases and Neurodegenerative Diseases by Chhangani, Deepak, Jana, Nihar Ranjan, Mishra, Amit

“…Impairment in the clearance of misfolded proteins by functional proteins leads to various late-onset neurodegenerative diseases. Cell applies a strict quality…”
Get full text

Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing by Upadhyay, Arun, Amanullah, Ayeman, Chhangani, Deepak, Mishra, Ribhav, Mishra, Amit

“…Graphical abstract The theme of “Balancing Acts of Selective Defenders: Emerging Multifaceted E3 Ubiquitin Ligases Determine Precision of Cellular fitness and…”
Get full text

Ibuprofen Induces Mitochondrial-Mediated Apoptosis Through Proteasomal Dysfunction by Upadhyay, Arun, Amanullah, Ayeman, Chhangani, Deepak, Joshi, Vibhuti, Mishra, Ribhav, Mishra, Amit

“…In routine course of life, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed antipyretic, analgesic, and anti-inflammatory drugs. It is a…”
Get full text

Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms by Upadhyay, Arun, Amanullah, Ayeman, Chhangani, Deepak, Mishra, Ribhav, Prasad, Amit, Mishra, Amit

“…In healthy cell, inappropriate accumulation of poor or damaged proteins is prevented by cellular quality control system. Autophagy and ubiquitin proteasome…”
Get full text

Gp78 involvement in cellular proliferation: Can act as a promising modulator for cell cycle regulatory proteins? by Joshi, Vibhuti, Upadhyay, Arun, Chhangani, Deepak, Amanullah, Ayeman, Sharan, Rajesh N., Mishra, Amit

“…In cells, protein synthesis and degradation are normal processes, which are tightly regulated by various cellular metabolic pathways. Cellular protein quality…”
Get full text

E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity by Mishra, Amit, Maheshwari, Megha, Chhangani, Deepak, Fujimori-Tonou, Noriko, Endo, Fumito, Joshi, Ajay Prakash, Jana, Nihar Ranjan, Yamanaka, Koji

“…Abstract Protein aggregation and ordered fibrillar amyloid deposition inside and outside of the central nervous system cells is the common pathologic hallmark…”
Get full text

Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway by Amanullah, Ayeman, Upadhyay, Arun, Chhangani, Deepak, Joshi, Vibhuti, Mishra, Ribhav, Yamanaka, Koji, Mishra, Amit

“…ABSTRACT Diclofenac is the most commonly used phenylacetic acid derivative non‐steroidal anti‐inflammatory drug (NSAID) that demonstrates significant…”
Get full text