Search Results - "Chevet, E"

Getting RIDD of RNA: IRE1 in cell fate regulation by Maurel, M., Chevet, E., Tavernier, J., Gerlo, S.

“…•XBP1 splicing and RIDD activities are differentially regulated functions of the UPR transducer IRE1.•RIDD is a conserved ancestral mechanism regulating…”
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Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers by Avril, T, Vauléon, E, Chevet, E

“…The unfolded protein response (UPR) is an adaptive cellular program used by eukaryotic cells to cope with protein misfolding stress. During tumor development,…”
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Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development by Chevet, E, Fessart, D, Delom, F, Mulot, A, Vojtesek, B, Hrstka, R, Murray, E, Gray, T, Hupp, T

“…Clinical studies have defined the core ‘genetic blueprint’ of a cancer cell, but this information does not necessarily predict the cancer phenotype. Signalling…”
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Integrated and Quantitative Proteomics of Human Tumors by Yakkioui, Y, Temel, Y, Chevet, E, Negroni, L

“…Quantitative proteomics represents a powerful approach for the comprehensive analysis of proteins expressed under defined conditions. These properties have…”
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Adaptive Preconditioning in Neurological Diseases – Therapeutic Insights from Proteostatic Perturbations by Mollereau, B, Rzechorzek, NM, Roussel, BD, Sedru, M, Van den Brink, D, Bailly-Maitre, B, Palladino, F, Medinas, D.B, Domingos, PM, Hunot, S, Chandran, S, Birman, S, Baron, T, Vivien, D, Duarte, CB, Ryoo, HD, Steller, H, Urano, F, Chevet, E, Kroemer, G, Ciechanover, A, Calabrese, EJ, Kaufman, RJ, Hetz, C

“…Abstract In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological…”
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Calnexin-dependent regulation of tunicamycin-induced apoptosis in breast carcinoma MCF-7 cells by Delom, F, Emadali, A, Cocolakis, E, Lebrun, J-J, Nantel, A, Chevet, E

“…The endoplasmic reticulum (ER) has evolved specific mechanisms to ensure protein folding as well as the maintenance of its own homeostasis. When these…”
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Association of Calnexin with Mutant Peripheral Myelin Protein-22 ex vivo: A Basis for "Gain-of-Function" ER Diseases by Dickson, K. M., Bergeron, J. J. M., Shames, I., Colby, J., Nguyen, D. T., Chevet, E., Thomas, D. Y., Snipes, G. J.

“…Schwann cell-derived peripheral myelin protein-22 (PMP-22) when mutated or overexpressed causes heritable neuropathies with a previously unexplained…”
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The MAP Kinase Phosphatase‐1 MKP‐1/DUSP1 Is a Regulator of Human Liver Response to Transplantation by Boutros, T., Nantel, A., Emadali, A., Tzimas, G., Conzen, S., Chevet, E., Metrakos, P. P

“…Orthotopic liver transplantation (OLT) continues to be the only remedy for end‐stage liver disease. In an attempt to decrease the ever‐widening gap between…”
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996 PREDICTIVE FACTORS OF RESPONSE TO SORAFENIB IN HEPATOCELLULAR CARCINOMA: A RETROSPECTIVE PILOT STUDY by Castain, C, Blanc, J.-F, Bioulac-Sage, P, Diallo, A, Chevet, E, Possenti, L, Trillaud, H, Le-Bail, B

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Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels by Navab, R, Pedraza, C, Fallavollita, L, Wang, N, Chevet, E, Auguste, P, Jenna, S, You, Z, Bikfalvi, A, Hu, J, O'Connor, R, Erickson, A, Mort, J S, Brodt, P

“…The lysosomal cysteine proteinase cathepsin L is involved in proteolytic processing of internalized proteins. In transformed cells, where it is frequently…”
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688 ENDOPLASMIC RETICULUM FOLDING AND QUALITY CONTROL IN CHOLANGIOCARCINOMA: A ROLE FOR ANTERIOR GRADIENT 2 by Lepreux, S, Bioulac-Sage, P, Mulot, A, Balabaud, C, Delom, F, Higa-Nishiyama, A, Bouchecareilh, M, Chevet, E

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Modeling of air pollution due to marine traffic in Marseille by Chevet, E., Boiron, O., Anselmet, F.

“…Marine traffic is constantly increasing and is unlikely to decrease in the years to come. However, merchant and tourist ships still use fuels with a high…”
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The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo by Pelletier, M F, Marcil, A, Sevigny, G, Jakob, C A, Tessier, D C, Chevet, E, Menard, R, Bergeron, J J, Thomas, D Y

“…Glucosidase II is an ER heterodimeric enzyme that cleaves sequentially the two innermost alpha-1,3-linked glucose residues from N-linked oligosaccharides on…”
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Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes by Chevet, E., Wong, H.N., Gerber, D., Cochet, C., Fazel, A., Cameron, P.H., Gushue, J.N., Thomas, D.Y., Bergeron, J.J.M.

“…Calnexin was initially identified as an endoplasmic reticulum (ER) type I integral membrane protein, phosphorylated on its cytosolic domain by ER‐associated…”
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Regulation of membrane trafficking by a novel Cdc42-related protein in Caenorhabditis elegans epithelial cells by Jenna, S, Caruso, M-E, Emadali, A, Nguyên, D T, Dominguez, M, Li, S, Roy, R, Reboul, J, Vidal, M, Tzimas, G N, Bossé, R, Chevet, E

“…Rho GTPases are mainly known for their implication in cytoskeleton remodeling. They have also been recently shown to regulate various aspects of membrane…”
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Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications by Almanza, Aitor, Carlesso, Antonio, Chintha, Chetan, Creedican, Stuart, Doultsinos, Dimitrios, Leuzzi, Brian, Luís, Andreia, McCarthy, Nicole, Montibeller, Luigi, More, Sanket, Papaioannou, Alexandra, Püschel, Franziska, Sassano, Maria Livia, Skoko, Josip, Agostinis, Patrizia, Belleroche, Jackie, Eriksson, Leif A., Fulda, Simone, Gorman, Adrienne M., Healy, Sandra, Kozlov, Andrey, Muñoz‐Pinedo, Cristina, Rehm, Markus, Chevet, Eric, Samali, Afshin

“…The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the…”
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When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response by González-Quiroz, Matías, Blondel, Alice, Sagredo, Alfredo, Hetz, Claudio, Chevet, Eric, Pedeux, Rémy

“…Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in…”
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Correlation of cell necrosis and tissue calcification with ischemia/reperfusion injury after liver transplantation by Tzimas, G.N., Afshar, M., Emadali, A., Chevet, E., Vali, H., Metrakos, P.P.

“…The cellular events following liver ischemia/reperfusion (I/R) during transplantation are largely unknown. The spectrum of I/R damage to the liver can be…”
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QM/MM Well-Tempered Metadynamics Study of the Mechanism of XBP1 mRNA Cleavage by Inositol Requiring Enzyme 1α RNase by Mahdizadeh, Sayyed Jalil, Pålsson, Emil, Carlesso, Antonio, Chevet, Eric, Eriksson, Leif A.

“…A range of in silico methodologies were herein employed to study the unconventional XBP1 mRNA cleavage mechanism performed by the unfolded protein response…”
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Calnexin family members as modulators of genetic diseases by Chevet, E., Jakob, C.A., Thomas, D.Y., Bergeron, J .J.M.

“…The endoplasmic reticulum (ER) is an intracellular compartment devoted to the synthesis, segregation and folding of soluble and membrane secretory proteins…”
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