Search Results - "Chevassut, Timothy J. T."

BRD4-mediated repression of p53 is a target for combination therapy in AML by Latif, Anne-Louise, Newcombe, Ashley, Li, Sha, Gilroy, Kathryn, Robertson, Neil A., Lei, Xue, Stewart, Helen J. S., Cole, John, Terradas, Maria Terradas, Rishi, Loveena, McGarry, Lynn, McKeeve, Claire, Reid, Claire, Clark, William, Campos, Joana, Kirschner, Kristina, Davis, Andrew, Lopez, Jonathan, Sakamaki, Jun-ichi, Morton, Jennifer P., Ryan, Kevin M., Tait, Stephen W. G., Abraham, Sheela A., Holyoake, Tessa, Higgins, Brian, Huang, Xu, Blyth, Karen, Copland, Mhairi, Chevassut, Timothy J. T., Keeshan, Karen, Adams, Peter D.

“…Acute myeloid leukemia (AML) is a typically lethal molecularly heterogeneous disease, with few broad-spectrum therapeutic targets. Unusually, most AML retain…”
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Thrombotic risk in COVID-19: a case series and case–control study by Stoneham, Simon M, Milne, Kate M, Nuttall, Elisabeth, Frew, Georgina H, Sturrock, Beattie RH, Sivaloganathan, Helena, Ladikou, Eleni E, Drage, Stephen, Phillips, Barbara, Chevassut, Timothy JT, Eziefula, Alice C

“…A possible association between COVID-19 infection and thrombosis, either as a direct consequence of the virus or as a complication of inflammation, is emerging…”
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Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis by Chaudry, Sabah F., Chevassut, Timothy J.

“…Acute myeloid leukaemia (AML) is a haematological malignancy characterized by clonal stem cell proliferation and aberrant block in differentiation. Dysfunction…”
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The renin–angiotensin system – a therapeutic target in COVID-19? by Sturrock, Beattie RH, Milne, Kate M, Chevassut, Timothy JT

“…COVID-19, caused by infection with SARS-CoV-2, is a disease characterised by cough, fever and fatigue, which progresses to life-threatening lung injury in…”
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Chloroquine and COVID-19 – a potential game changer? by Sturrock, Beattie RH, Chevassut, Timothy JT

“…The novel coronavirus SARS-CoV-2, causing the disease COVID-19, first emerged in Wuhan, China in December 2019 and has now spread to 203 countries or…”
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A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies by McGovern, Andrew P., Powell, Benjamin E., Chevassut, Timothy J.T.

“…Recent advances have highlighted the central role of DNA methylation in leukemogenesis and have led to clinical trials of epigenetic therapy, notably…”
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BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death by Stewart, Helen J. S., Chaudry, Sabah, Crichlow, Asante, Luiling Feilding, Freya, Chevassut, Timothy J. T.

“…S100A8 and S100A9 are both members of the S100 family and have been shown to play roles in myeloid differentiation, autophagy, apoptosis, and chemotherapy…”
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Haemolytic anaemia: don't leave it out in the cold by Horne, Gillian A, Chevassut, Timothy J T, Fidler, Katy, Wynne, Catherine

“…This clinical case highlights the diagnostic odyssey of an adolescent girl presenting to A&E with non-specific headaches and chest pain. The case will describe…”
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Characterisation of two methods involving double-stranded rna for the functional genetic analysis of the murine embryonic stem cell: antisense gene trapping & rna interference by Chevassut, Timothy J. T

“…Murine embryonic stem cells are derived from the inner cell mass of a pre-implantation mouse blastocyst. These cells exhibit dual defining characteristics of…”
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