Search Results - "Cheung, Tony"

AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies by Rhyasen, Garrett W, Hattersley, Maureen M, Yao, Yi, Dulak, Austin, Wang, Wenxian, Petteruti, Philip, Dale, Ian L, Boiko, Scott, Cheung, Tony, Zhang, Jingwen, Wen, Shenghua, Castriotta, Lillian, Lawson, Deborah, Collins, Michael, Bao, Larry, Ahdesmaki, Miika J, Walker, Graeme, O'Connor, Greg, Yeh, Tammie C, Rabow, Alfred A, Dry, Jonathan R, Reimer, Corinne, Lyne, Paul, Mills, Gordon B, Fawell, Stephen E, Waring, Michael J, Zinda, Michael, Clark, Edwin, Chen, Huawei

“…The bromodomain and extraterminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin…”
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Structural Basis of Substrate Methylation and Inhibition of SMYD2 by Ferguson, Andrew D., Larsen, Nicholas A., Howard, Tina, Pollard, Hannah, Green, Isabelle, Grande, Christie, Cheung, Tony, Garcia-Arenas, Renee, Cowen, Scott, Wu, Jiaquan, Godin, Robert, Chen, Huawei, Keen, Nicholas

“…Protein lysine methyltransferases are important regulators of epigenetic signaling. These enzymes catalyze the transfer of donor methyl groups from…”
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Biochemical Characterization of Human SET and MYND Domain-Containing Protein 2 Methyltransferase by Wu, Jiaquan, Cheung, Tony, Grande, Christie, Ferguson, Andrew D, Zhu, Xiahui, Theriault, Kelly, Code, Erin, Birr, Cynthia, Keen, Nick, Chen, Huawei

“…SET and MYND domain-containing protein 2 (SMYD2) is a protein lysine methyltransferase that catalyzes the transfer of methyl groups from S-adenosylmethionine…”
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system by Magdaleno, Susan, Jensen, Patricia, Brumwell, Craig L, Seal, Anna, Lehman, Karen, Asbury, Andrew, Cheung, Tony, Cornelius, Tommie, Batten, Diana M, Eden, Christopher, Norland, Shannon M, Rice, Dennis S, Dosooye, Nilesh, Shakya, Sundeep, Mehta, Perdeep, Curran, Tom

“…BGEM contains images for more than 400 genes with DNA binding and/or transcription factor activity, and more than 300 genes with protein translation and…”
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Prospective randomized controlled trial comparing partially absorbable lightweight mesh and multifilament polyester anatomical mesh in laparoscopic inguinal hernia repair by Wong, John CC, Yang, George PC, Cheung, Tony PP, Li, Michael KW

“…Introduction Tension‐free mesh repair is currently the gold standard treatment for inguinal hernia. Recent evidence has shown that both open and laparoscopic…”
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Influence of degree of saturation on soil nail pull-out resistance in compacted completely decomposed granite fill by Su, Li-Jun, Chan, Terence C.F, Shiu, Y.K, Cheung, Tony, Yin, Jian-Hua

“…The nail-soil interface shear strength is a key parameter in the design and stability assessment of soil nailing systems. A number of factors will influence…”
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AIDS-Related Cancer in the Era of Highly Active Antiretroviral Therapy (HAART): A Model of the Interplay of the Immune System, Virus, and Cancer.-"On the Offensive-The Trojan Horse is Being Destroyed"- Part A: Kaposi's Sarcoma by Cheung, Tony W.

“…The introduction of highly active antiretroviral therapy (HAART), aimed at controlling human immunodeficiency virus (HIV), has been associated with a dramatic…”
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Atovaquone Compared with Dapsone for the Prevention of Pneumocystis carinii Pneumonia in Patients with HIV Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, or Both by El-Sadr, Wafaa M, Murphy, Robert L, Yurik, Teresa McCabe, Luskin-Hawk, Roberta, Cheung, Tony W, Balfour, Henry H, Eng, Robert, Hooton, Thomas M, Kerkering, Thomas M, Schutz, Malte, van der Horst, Charles, Hafner, Richard

“…The prevention of Pneumocystis carinii pneumonia has had a substantial influence on the course of human immunodeficiency virus (HIV) disease. 1 , 2 Although…”
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Evidence for Multiclonality in Multicentric Kaposi's Sarcoma by Gill, Parkash S., Tsai, Yvonne C., Rao, Adupa P., Spruck, Charles H., Zheng, Tong, Harrington, William A., Cheung, Tony, Nathwani, Bharat, Jones, Peter A.

“…Kaposi's sarcoma (KS) develops in a variety of clinical states and is the most common tumor seen in patients with HIV-1 infection. KS develops as a multifocal…”
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AIDS-Related Cancer in the Era of Highly Active Antiretroviral Therapy (HAART): A Model of the Interplay of the Immune System, Virus, and Cancer. "On the Offensive-The Trojan Horse is Being Destroyed"-Part B: Malignant Lymphoma by Cheung, Tony W.

“…The impact of highly active antiretroviral therapy (HAART) on the incidence of non-Hodgkin's lymphoma was less obvious initially, although primary central…”
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Quantitation of disease severity using computer-derived airway measurements in idiopathic pulmonary fibrosis by McLaverty, Davina, Jacob, Joseph, Cheung, Tony, Pakzad, Ashkan

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Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5 by Wilson, M D, Riemer, C, Martindale, D W, Schnupf, P, Boright, A P, Cheung, T L, Hardy, D M, Schwartz, S, Scherer, S W, Tsui, L C, Miller, W, Koop, B F

“…Chromosome 7q22 has been the focus of many cytogenetic and molecular studies aimed at delineating regions commonly deleted in myeloid leukemias and…”
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Neuroendocrine consequences of fasting in adult male macaques: effects of recombinant rhesus macaque leptin infusion by Lado-Abeal, J, Hickox, J R, Cheung, T L, Veldhuis, J D, Hardy, D M, Norman, R L

“…Fasting inhibits the gonadotropic axis and stimulates the corticotropic and somatotropic axes. Since leptin is a product of fat cells that has been implicated…”
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Development of a Novel B‑Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6 by McCoull, William, Cheung, Tony, Anderson, Erica, Barton, Peter, Burgess, Jonathan, Byth, Kate, Cao, Qing, Castaldi, M. Paola, Chen, Huawei, Chiarparin, Elisabetta, Carbajo, Rodrigo J, Code, Erin, Cowan, Suzanna, Davey, Paul R, Ferguson, Andrew D, Fillery, Shaun, Fuller, Nathan O, Gao, Ning, Hargreaves, David, Howard, Martin R, Hu, Jun, Kawatkar, Aarti, Kemmitt, Paul D, Leo, Elisabetta, Molina, Daniel M, O’Connell, Nichole, Petteruti, Philip, Rasmusson, Timothy, Raubo, Piotr, Rawlins, Philip B, Ricchiuto, Piero, Robb, Graeme R, Schenone, Monica, Waring, Michael J, Zinda, Michael, Fawell, Stephen, Wilson, David M

“…B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological cancers but high quality chemical probes are necessary to evaluate its…”
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Abstract 1665: AZ304, a novel dual BRAF inhibitor, exerts antitumor activity in colorectal cancers independent of BRAF status by Ma, Rui, Xu, Ling, Che, Xiaofang, Qu, Xiujuan, Drew, Lisa, Shen, Minhui, Cheung, Tony, Liu, Yunpeng

“…Abstract Background: BRAF mutation is associated with poor clinical outcome of malignant tumors and mediates resistance to chemotherapy and targeted therapy…”
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Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model by De Fusco, Claudia, Schimpl, Marianne, Börjesson, Ulf, Cheung, Tony, Collie, Iain, Evans, Laura, Narasimhan, Priyanka, Stubbs, Christopher, Vazquez-Chantada, Mercedes, Wagner, David J, Grondine, Michael, Sanders, Matthew G, Tentarelli, Sharon, Underwood, Elizabeth, Argyrou, Argyrides, Smith, James M, Lynch, James T, Chiarparin, Elisabetta, Robb, Graeme, Bagal, Sharan K, Scott, James S

“…MAT2a is a methionine adenosyltransferase that synthesizes the essential metabolite S-adenosylmethionine (SAM) from methionine and ATP. Tumors bearing the…”
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Programmed Cell Death Receptor (PD-1) Ligand (PD-L1) expression in Philadelphia chromosome-negative myeloproliferative neoplasms by Wang, Jen-Chin, Chen, Chi, Kundra, Ajay, Kodali, Sreenath, Pandey, Anita, Wong, Ching, Cheung, Tony, Gotlieb, Vladimir, Joseph, Gardith, Tribie, Sophia

“…•This is the largest and first cohort study of PD-1, PD-L1 in Ph (-) MPN patients.•PD-1, PD-L1 are increased in ET, PV, and MF when they grouped as MPN than…”
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Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors by McCoull, William, Abrams, Roman D, Anderson, Erica, Blades, Kevin, Barton, Peter, Box, Matthew, Burgess, Jonathan, Byth, Kate, Cao, Qing, Chuaqui, Claudio, Carbajo, Rodrigo J, Cheung, Tony, Code, Erin, Ferguson, Andrew D, Fillery, Shaun, Fuller, Nathan O, Gangl, Eric, Gao, Ning, Grist, Matthew, Hargreaves, David, Howard, Martin R, Hu, Jun, Kemmitt, Paul D, Nelson, Jennifer E, O’Connell, Nichole, Prince, D. Bryan, Raubo, Piotr, Rawlins, Philip B, Robb, Graeme R, Shi, Junjie, Waring, Michael J, Whittaker, David, Wylot, Marta, Zhu, Xiahui

“…Inhibition of the protein–protein interaction between B-cell lymphoma 6 (BCL6) and corepressors has been implicated as a therapeutic target in diffuse large…”
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Development of a Series of Pyrrolopyridone MAT2A Inhibitors by Atkinson, Stephen J., Bagal, Sharan K., Argyrou, Argyrides, Askin, Sean, Cheung, Tony, Chiarparin, Elisabetta, Coen, Muireann, Collie, Iain T., Dale, Ian L., De Fusco, Claudia, Dillman, Keith, Evans, Laura, Feron, Lyman J., Foster, Alison J., Grondine, Michael, Kantae, Vasudev, Lamont, Gillian M., Lamont, Scott, Lynch, James T., Nilsson Lill, Sten, Robb, Graeme R., Saeh, Jamal, Schimpl, Marianne, Scott, James S., Smith, James, Srinivasan, Bharath, Tentarelli, Sharon, Vazquez-Chantada, Mercedes, Wagner, David, Walsh, Jarrod J., Watson, David, Williamson, Beth

“…The optimization of an allosteric fragment, discovered by differential scanning fluorimetry, to an in vivo MAT2a tool inhibitor is discussed. The…”
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Structure-Based Optimization of a Series of Covalent, Cell Active Bfl‑1 Inhibitors by Lucas, Simon C. C., Blackwell, J. Henry, Börjesson, Ulf, Hargreaves, David, Milbradt, Alexander G., Bostock, Mark J., Ahmed, Samiyah, Beaumont, Kevin, Cheung, Tony, Demanze, Sylvain, Gohlke, Andrea, Guerot, Carine, Haider, Afreen, Kantae, Vasudev, Kauffman, Gregory W., Kinzel, Olaf, Kupcova, Lea, Lainchbury, Michael D., Lamb, Michelle L., Leon, Leonardo, Palisse, Adeline, Sacchetto, Claudia, Storer, R. Ian, Su, Nancy, Thomson, Clare, Vales, John, Chen, Yunhua, Hu, Xiaolong

“…Bfl-1, a member of the Bcl-2 family of proteins, plays a crucial role in apoptosis regulation and has been implicated in cancer cell survival and resistance to…”
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