Search Results - "Cheung, Sheldon T."

Enamine N‑Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents by Kang, Dahye, Cheung, Sheldon T, Wong-Rolle, Andrew, Kim, Justin

“…Tumor hypoxia induces the large-scale adaptive reprogramming of cancer cells, promoting their transformation into highly invasive and metastatic species that…”
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Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation by Cheung, Sheldon T, Miller, Michelle S, Pacoma, Reynand, Roland, Jason, Liu, Jian, Schumacher, Andrew M, Hsieh-Wilson, Linda C

“…Glycosaminoglycans (GAGs) play critical roles in diverse processes ranging from viral infection to neuroregeneration. Their regiospecific sulfation patterns,…”
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Bioorthogonal Hydroamination of Push–Pull‐Activated Linear Alkynes by Kang, Dahye, Cheung, Sheldon T., Kim, Justin

“…A bioorthogonal reaction between N,N‐dialkylhydroxylamines and push–pull‐activated halogenated alkynes is described. We explore the use of rehybridization…”
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End-to-End Throughput Chemical Proteomics for Photoaffinity Labeling Target Engagement and Deconvolution by Cheung, Sheldon T., Kim, Yongkang, Cho, Ji-Hoon, Brandvold, Kristoffer R., Ghosh, Brahma, Del Rosario, Amanda M., Bell-Temin, Harris

“…Photoaffinity labeling (PAL) methodologies have proven to be instrumental for the unbiased deconvolution of protein–ligand binding events in physiologically…”
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Chemoenzymatic Labeling, Detection and Profiling of Core Fucosylation in Live Cells by Zhu, Qiang, Chaubard, Jean-Luc, Geng, Didi, Shen, Jiechen, Ban, Lan, Cheung, Sheldon T., Wei, Fangyu, Liu, Yating, Sun, Haofan, Calderon, Angie, Dong, Wenbo, Qin, Weijie, Li, Tiehai, Wen, Liuqing, Wang, Peng George, Sun, Shisheng, Yi, Wen, Hsieh-Wilson, Linda C.

“…Core fucosylation, the attachment of an α-1,6-linked-fucose to the N-glycan core pentasaccharide, is an abundant protein modification that plays critical roles…”
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Bioorthogonal Hydroamination of Push–Pull‐Activated Linear Alkynes by Kang, Dahye, Cheung, Sheldon T., Kim, Justin

“…A bioorthogonal reaction between N,N‐dialkylhydroxylamines and push–pull‐activated halogenated alkynes is described. We explore the use of rehybridization…”
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