Search Results - "Cheung, Lawrence H."

Production of Recombinant Gelonin Using an Automated Liquid Chromatography System by Berstad, Maria E B, Cheung, Lawrence H, Weyergang, Anette

“…Advances in recombinant DNA technology have opened up new possibilities of exploiting toxic proteins for therapeutic purposes. Bringing forth these protein…”
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Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B by Cheung, Lawrence H, Zhao, Yunli, Alvarez-Cienfuegos, Ana, Mohamedali, Khalid A, Cao, Yu J, Hittelman, Walter N, Rosenblum, Michael G

“…Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting…”
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Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells by Zhou, Hong, Marks, John W, Hittelman, Walter N, Yagita, Hideo, Cheung, Lawrence H, Rosenblum, Michael G, Winkles, Jeffrey A

“…TNF-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor (FGF)-inducible 14 (Fn14) are a TNF superfamily ligand-receptor pair involved in many…”
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Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors by HONG ZHOU, HITTELMAN, Walter N, YAGITA, Hideo, CHEUNG, Lawrence H, MARTIN, Stuart S, WINKLES, Jeffrey A, ROSENBLUM, Michael G

“…The TNF-like weak inducer of apoptosis (TWEAK; TNFSF12) receptor Fn14 (TNFRSF12A) is expressed at low levels in normal tissues but frequently highly expressed…”
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Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B by Alvarez de Cienfuegos, Ana, Cheung, Lawrence H, Mohamedali, Khalid A, Whitsett, Timothy G, Winkles, Jeffrey A, Hittelman, Walter N, Rosenblum, Michael G

“…Antibody-drug conjugates are an exceptional and useful therapeutic tool for multiple diseases, particularly for cancer treatment. We previously showed that the…”
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Construction and Characterization of Novel, Recombinant Immunotoxins Targeting the Her2/neu Oncogene Product: In vitro and In vivo Studies by YU CAO, MARKS, James D, MARKS, John W, CHEUNG, Lawrence H, KIM, Sehoon, ROSENBLUM, Michael G

“…The goal of this study was to characterize a series of anti-Her2/neu immunotoxin constructs to identify how different antibodies and linker choices affect the…”
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Multi-modality therapeutics with potent anti-tumor effects: photochemical internalization enhances delivery of the fusion toxin scFvMEL/rGel by Selbo, Pål K, Rosenblum, Michael G, Cheung, Lawrence H, Zhang, Wendy, Berg, Kristian

“…There is a need for drug delivery systems (DDS) that can enhance cytosolic delivery of anti-cancer drugs trapped in the endo-lysosomal compartments. Exposure…”
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Recombinant CPE fused to tumor necrosis factor targets human ovarian cancer cells expressing the claudin-3 and claudin-4 receptors by Yuan, Xiaoqin, Lin, Xinjian, Manorek, Gerald, Kanatani, Isao, Cheung, Lawrence H, Rosenblum, Michael G, Howell, Stephen B

“…Using gene expression profiling, others and we have recently found that claudin-3 ( CLDN3 ) and claudin-4 ( CLDN4 ) are two of the most highly and consistently…”
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The rGel/BLyS Fusion Toxin Inhibits Diffuse Large B-cell Lymphoma Growth In Vitro and In Vivo by Lyu, Mi-Ae, Rai, Deepak, Ahn, Kwang Seok, Sung, Bokyung, Cheung, Lawrence H., Marks, John W., Aggarwal, Bharat B., Aguiar, Ricardo C.T., Gandhi, Varsha, Rosenblum, Michael G.

“…Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of B-cell non-Hodgkin lymphoma (NHL) and accounts for 30%to 40%of NHL. Molecules targeting…”
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Antitumor activity of fibroblast growth factor receptor 3–specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis by Martínez-Torrecuadrada, Jorge L, Cheung, Lawrence H, López-Serra, Paula, Barderas, Rodrigo, Cañamero, Marta, Ferreiro, Sergio, Rosenblum, Michael G, Casal, J Ignacio

“…Human single-chain Fv directed against fibroblast growth factor receptor 3 (FGFR3) have been shown to block proliferation of RT112 bladder carcinoma cells in…”
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Cytotoxicity of VEGF121/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2 by Mohamedali, Khalid A, Ran, Sophia, Gomez-Manzano, Candelaria, Ramdas, Latha, Xu, Jing, Kim, Sehoon, Cheung, Lawrence H, Hittelman, Walter N, Zhang, Wei, Waltenberger, Johannes, Thorpe, Philip E, Rosenblum, Michael G

“…Abstract Background: The fusion protein VEGF121 /rGel composed of the growth factor VEGF121 and the plant toxin gelonin targets the tumor neovasculature and…”
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Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2 by Redis, Roxana S., Vela, Luz E., Lu, Weiqin, Ferreira de Oliveira, Juliana, Ivan, Cristina, Rodriguez-Aguayo, Cristian, Adamoski, Douglas, Pasculli, Barbara, Taguchi, Ayumu, Chen, Yunyun, Fernandez, Agustin F., Valledor, Luis, Van Roosbroeck, Katrien, Chang, Samuel, Shah, Maitri, Kinnebrew, Garrett, Han, Leng, Atlasi, Yaser, Cheung, Lawrence H., Huang, Gilbert Y., Monroig, Paloma, Ramirez, Marc S., Catela Ivkovic, Tina, Van, Long, Ling, Hui, Gafà, Roberta, Kapitanovic, Sanja, Lanza, Giovanni, Bankson, James A., Huang, Peng, Lai, Stephen Y., Bast, Robert C., Rosenblum, Michael G., Radovich, Milan, Ivan, Mircea, Bartholomeusz, Geoffrey, Liang, Han, Fraga, Mario F., Widger, William R., Hanash, Samir, Berindan-Neagoe, Ioana, Lopez-Berestein, Gabriel, Ambrosio, Andre L.B., Gomes Dias, Sandra M., Calin, George A.

“…Altered energy metabolism is a cancer hallmark as malignant cells tailor their metabolic pathways to meet their energy requirements. Glucose and glutamine are…”
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The Antimelanoma Immunocytokine scFvMEL/TNF Shows Reduced Toxicity and Potent Antitumor Activity against Human Tumor Xenografts by Liu, Yuying, Zhang, Weihe, Cheung, Lawrence H., Niu, Ting, Wu, Qingping, Li, Chun, Van Pelt, Carolyn S., Rosenblum, Michael G.

“…The immunocytokine scFvMEL/TNF, a fusion protein composed of human tumor necrosis factor (TNF) and a single-chain Fv antibody (scFv) scFvMEL targeting the…”
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Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity by Liu, Yuying, Zhang, Weihe, Niu, Ting, Cheung, Lawrence H., Munshi, Anupama, Meyn, Raymond E., Rosenblum, Michael G.

“…GrB/scFvMEL, a fusion protein composed of human granzyme B (GrB) and the single-chain antibody scFvMEL, targets melanoma gp240 antigen and exerts impressive…”
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Characterization and Mechanistic Studies of a Novel Melanoma-Targeting Construct Containing IκBa for Specific Inhibition of Nuclear Factor-κB Activity by Zhou, Hong, Liu, Yuying, Cheung, Lawrence H., Kim, Sehoon, Zhang, Weihe, Mohamedali, Khalid A., Anand, Preetha, Hittelman, Walter N., Aggarwal, Bharat B., Rosenblum, Michael G.

“…The transcription factor nuclear factor-κB (NF-κB) is a central mediator of growth and homeostasis for both normal and neoplastic cells. IκBα is the natural…”
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Light-enhanced VEGF121/rGel: A tumor targeted modality with vascular and immune-mediated efficacy by Weyergang, Anette, Fremstedal, Ane S., Skarpen, Ellen, Peng, Qian, Mohamedali, Khalid A., Eng, Marius S., Cheung, Lawrence H., Rosenblum, Michael G., Waltenberger, Johannes, Berg, Kristian

“…Interactions between stromal cells and tumor cells pay a major role in cancer growth and progression. This is reflected in the composition of anticancer drugs…”
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Targeted delivery of human pro-apoptotic enzymes to tumor cells: In vitro studies describing a novel class of recombinant highly cytotoxic agents by Liu, Yuying, Cheung, Lawrence H, Hittelman, Walter N, Rosenblum, Michael G

“…The serine protease granzyme B (GrB, 25 kDa) can initiate apoptosis by multiple mechanisms including directly activating caspases, inducing DNA fragmentation,…”
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A novel in vivo model using immunotoxin in the absence of p-glycoprotein to achieve ultra selective depletion of target cells: Applications in trogocytosis and beyond by Brown, Kathryn, Meader, Lucy, Nowocin, Anna, Edwards, Lindsey A., Cheung, Lawrence H., Smith, Richard A., Rosenblum, Michael G., Wong, Wilson

“…A commonly employed method to determine the function of a particular cell population and to assess its contribution to the overall system in vivo is to…”
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Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin by Weyergang, Anette, Cheung, Lawrence H, Rosenblum, Michael G, Mohamedali, Khalid A, Peng, Qian, Waltenberger, Johannes, Berg, Kristian

“…Vascular targeting for cancer is increasingly recognized as a therapeutic strategy although the lack of objective responses and the development of resistance…”
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Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization by Olsen, Cathrine Elisabeth, Cheung, Lawrence H, Weyergang, Anette, Berg, Kristian, Vallera, Daniel A, Rosenblum, Michael G, Selbo, Pål Kristian

“…The objective of this study was to develop and explore a novel CD133-targeting immunotoxin (IT) for use in combination with the endosomal escape method…”
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