Search Results - "Cheung, Kit Wun Kathy"

Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models by Sane, Rucha, Cheung, Kit Wun Kathy, Kovács, Péter, Farasyn, Taleah, Li, Ruina, Bui, Annamaria, Musib, Luna, Kis, Emese, Plise, Emile, Gáborik, Zsuzsanna

“…Organic anion-transporting polypeptide (OATP) 1B1/3-mediated drug-drug interaction (DDI) potential is evaluated in vivo with rosuvastatin (RST) as a probe…”
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Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters by Cheung, Kit Wun Kathy, Groen, Bianca D., Burckart, Gilbert J., Zhang, Lei, Wildt, Saskia N., Huang, Shiew‐Mei

“…Developmental changes in the biological processes involved in the disposition of drugs, such as membrane transporter expression and activity, may alter the…”
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Assessment of cytochrome P450 3A4-mediated drug–drug interactions for ipatasertib using a fit-for-purpose physiologically based pharmacokinetic model by Jing, Jing, Chen, Yuan, Musib, Luna, Jin, Jin Y., Cheung, Kit Wun Kathy, Yoshida, Kenta, Sane, Rucha

“…Purpose Ipatasertib, a potent and highly selective small-molecule inhibitor of AKT, is currently under investigation for treatment of cancer. Ipatasertib is a…”
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Advancing drug development in pediatric oncology, a focus on cancer biology and targeted therapies: iMATRIX platform by Uguen, Marianne, Hilton, Magalie, Farid-Kapadia, Mufiza, Datye, Asim, Chohan, Saibah, Carlucci, Claudia, Dixon, Mark, Elze, Markus, Chen, Yingjia, Cheung, Kit Wun Kathy, Sane, Rucha, Zheng, Maoxia, Choi, YounJeong

“…With the development of novel treatment therapies as well as evolving and innovative approaches to conduct clinical trials, the landscape of pediatric oncology…”
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Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies by Yee, Sook Wah, Stecula, Adrian, Chien, Huan-Chieh, Zou, Ling, Feofanova, Elena V, van Borselen, Marjolein, Cheung, Kit Wun Kathy, Yousri, Noha A, Suhre, Karsten, Kinchen, Jason M, Boerwinkle, Eric, Irannejad, Roshanak, Yu, Bing, Giacomini, Kathleen M

“…Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key…”
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Exploring the Impact of Hepatic Impairment on Pralsetinib Pharmacokinetics by Cheung, Kit Wun Kathy, Tang, Yang, Anders, Doreen, Barata, Teresa, Scalori, Astrid, Agarwal, Priya, Sane, Rucha, Cheeti, Sravanthi

“…Pralsetinib is a kinase inhibitor indicated for the treatment of metastatic rearranged during transfection ( ) fusion-positive non-small cell lung cancer…”
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P228 - Assay calibration to refine prediction of OATP1B1/1B3 mediated drug-drug interactions (DDI) based on in vitro uptake transport assay data by Kovacs, Peter, Sane, Rucha, Kathy Cheung, Kit Wun, Kis, Emese, Plise, Emile, Gaborik, Zsuzsanna

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Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics by Cheeti, Sravanthi, Deng, Yuzhong, Chang, Ilsung, Georgescu, Isabela, Templeton, Ian, Choong, Nicholas, Cheung, Kit Wun Kathy, Girish, Sandhya, Musib, Luna

“…Cobimetinib is a kinase inhibitor indicated for use in combination with vemurafenib for treatment of unresectable/metastatic melanoma with specific BRAF…”
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Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling by Hunt, J. Porter, Dubinsky, Samuel, McKnite, Autumn M., Cheung, Kit Wun Kathy, Groen, Bianca D., Giacomini, Kathleen M., Wildt, Saskia N., Edginton, Andrea N., Watt, Kevin M.

“…Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric…”
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Evaluation of Ipatasertib Interactions with Itraconazole and Coproporphyrin I and III in a Single Drug Interaction Study in Healthy Subjects by Sane, Rucha S, Cheung, Kit Wun Kathy, Cho, Eunpi, Liederer, Bianca M, Hanover, Justin, Malhi, Vikram, Plise, Emile, Wong, Susan, Musib, Luna

“…Ipatasertib is a pan-AKT inhibitor in development for the treatment of cancer. Ipatasertib was metabolized by CYP3A4 to its major metabolite, M1 (G-037720),…”
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GDC-0810 Pharmacokinetics and Transporter-Mediated Drug Interaction Evaluation with an Endogenous Biomarker in the First-in-Human, Dose Escalation Study by Cheung, Kit Wun Kathy, Yoshida, Kenta, Cheeti, Sravanthi, Chen, Buyun, Morley, Roland, Chan, Iris T, Sahasranaman, Srikumar, Liu, Lichuan

“…GDC-0810 (Cheeti et al., 2018) is an orally bioavailable, selective estrogen receptor (ER) degrader developed to treat ER-positive breast cancer. A…”
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A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization by Cheung, Kit Wun Kathy, Groen, Bianca D., Spaans, Edwin, Borselen, Marjolein D., Bruijn, Adrianus C.J.M., Simons‐Oosterhuis, Ytje, Tibboel, Dick, Samsom, Janneke N., Verdijk, Robert M., Smeets, Bart, Zhang, Lei, Huang, Shiew‐Mei, Giacomini, Kathleen M., Wildt, Saskia N.

“…Human renal membrane transporters play key roles in the disposition of renally cleared drugs and endogenous substrates, but their ontogeny is largely unknown…”
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The Effect of Uremic Solutes on the Organic Cation Transporter 2 by Cheung, Kit Wun Kathy, Hsueh, Chia-Hsiang, Zhao, Ping, Meyer, Timothy W, Zhang, Lei, Huang, Shiew-Mei, Giacomini, Kathleen M

“…Chronic kidney disease (CKD) is characterized by the accumulation of uremic solutes; however, little is known about how these solutes affect drug absorption…”
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P227 - Pharmacokinetics of GDC-0810 and its interaction with coproporphyrin i in the first-in-human, ascending dose study in women with locally advanced or metastatic estrogen receptor positive breast cancer by Kathy Cheung, Kit Wun, Yoshida, Kenta, Cheeti, Sravanthi, Chen, Buyun, Morley, Roland, Chan, Iris T., Sahasranaman, Srikumar, Liu, Lichuan

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A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization by Cheung, Kit Wun Kathy, Groen, Bianca D., Spaans, Edwin, Borselen, Marjolein D., Bruijn, Adrianus C. J. M., Simons‐Oosterhuis, Ytje, Tibboel, Dick, Samsom, Janneke N., Verdijk, Robert M., Smeets, Bart, Zhang, Lei, Huang, Shiew‐Mei, Giacomini, Kathleen M., Wildt, Saskia N.

“…Not provided…”
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