Search Results - "Cheung, Joseph Y."

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition by Luongo, Timothy S., Lambert, Jonathan P., Yuan, Ancai, Zhang, Xueqian, Gross, Polina, Song, Jianliang, Shanmughapriya, Santhanam, Gao, Erhe, Jain, Mohit, Houser, Steven R., Koch, Walter J., Cheung, Joseph Y., Madesh, Muniswamy, Elrod, John W.

“…Cardiac contractility is mediated by a variable flux in intracellular calcium (Ca2+), thought to be integrated into mitochondria via the mitochondrial calcium…”
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TRPM2 protects against tissue damage following oxidative stress and ischaemia–reperfusion by Miller, Barbara A., Cheung, Joseph Y.

“…TRPM channels are a subgroup of the transient receptor potential (TRP) channel superfamily whose members have important roles in cell proliferation and…”
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The human ion channel TRPM2 modulates migration and invasion in neuroblastoma through regulation of integrin expression by Bao, Lei, Festa, Fernanda, Hirschler-Laszkiewicz, Iwona, Keefer, Kerry, Wang, Hong-Gang, Cheung, Joseph Y., Miller, Barbara A.

“…Transient receptor potential channel TRPM2 is highly expressed in many cancers and involved in regulation of key physiological processes including…”
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Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes by Tahrir, Farzaneh G., Knezevic, Tijana, Gupta, Manish K., Gordon, Jennifer, Cheung, Joseph Y., Feldman, Arthur M., Khalili, Kamel

“…Mitochondrial abnormalities impact the development of myofibrillar myopathies. Therefore, understanding the mechanisms underlying the removal of dysfunctional…”
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The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation by Hirschler-Laszkiewicz, Iwona, Chen, Shu-Jen, Bao, Lei, Wang, JuFang, Zhang, Xue-Qian, Shanmughapriya, Santhanam, Keefer, Kerry, Madesh, Muniswamy, Cheung, Joseph Y, Miller, Barbara A

“…Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an essential function in cell survival and is highly expressed in many cancers…”
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Current Landscape of Heart Failure Gene Therapy by Kieserman, Jake M, Myers, Valerie D, Dubey, Praveen, Cheung, Joseph Y, Feldman, Arthur M

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MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity by Hoffman, Nicholas E., Chandramoorthy, Harish C., Shamugapriya, Santhanam, Zhang, Xueqian, Rajan, Sudarsan, Mallilankaraman, Karthik, Gandhirajan, Rajesh Kumar, Vagnozzi, Ronald J., Ferrer, Lucas M., Sreekrishnanilayam, Krishnalatha, Natarajaseenivasan, Kalimuthusamy, Vallem, Sandhya, Force, Thomas, Choi, Eric T., Cheung, Joseph Y., Madesh, Muniswamy

“…Resting mitochondrial matrix Ca2+ is maintained through a mitochondrial calcium uptake 1 (MICU1)-established threshold inhibition of mitochondrial calcium…”
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GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis by Gupta, Manish K., Tahrir, Farzaneh G., Knezevic, Tijana, White, Martyn K., Gordon, Jennifer, Cheung, Joseph Y., Khalili, Kamel, Feldman, Arthur M.

“…ABSTRACT Bag5 is a member of the BAG family of molecular chaperone regulators and is unusual in that it consists of five BAG domains, which function as…”
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Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility by Thal, David M, Homan, Kristoff T, Chen, Jun, Wu, Emily K, Hinkle, Patricia M, Huang, Z. Maggie, Chuprun, J. Kurt, Song, Jianliang, Gao, Erhe, Cheung, Joseph Y, Sklar, Larry A, Koch, Walter J, Tesmer, John J.G

“…G protein-coupled receptor kinase 2 (GRK2) is a well-established therapeutic target for the treatment of heart failure. Herein we identify the selective…”
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HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy by Gupta, Manish K., Kaminski, Rafal, Mullen, Brian, Gordon, Jennifer, Burdo, Tricia H., Cheung, Joseph Y., Feldman, Arthur M., Madesh, Muniswamy, Khalili, Kamel

“…Cardiovascular disease is a leading cause of co-morbidity in HIV-1 positive patients, even those in whom plasma virus levels are well-controlled. The…”
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BAG3: a new player in the heart failure paradigm by Knezevic, Tijana, Myers, Valerie D., Gordon, Jennifer, Tilley, Douglas G., Sharp, Thomas E., Wang, JuFang, Khalili, Kamel, Cheung, Joseph Y., Feldman, Arthur M.

“…BAG3 is a cellular protein that is expressed predominantly in skeletal and cardiac muscle but can also be found in the brain and in the peripheral nervous…”
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The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1 by Hirschler-Laszkiewicz, Iwona, Festa, Fernanda, Huang, Suming, Moldovan, George-Lucian, Nicolae, Claudia, Dhoonmoon, Ashna, Bao, Lei, Keefer, Kerry, Chen, Shu-jen, Wang, Hong-Gang, Cheung, Joseph Y., Miller, Barbara A.

“…Transient receptor potential channel melastatin 2 (TRPM2) is highly expressed in cancer and has an essential function in preserving viability through…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors by Waldschmidt, Helen V, Homan, Kristoff T, Cruz-Rodríguez, Osvaldo, Cato, Marilyn C, Waninger-Saroni, Jessica, Larimore, Kelly M, Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y, Kirchhoff, Paul D, Koch, Walter J, Tesmer, John J. G, Larsen, Scott D

“…G protein-coupled receptors (GPCRs) are central to many physiological processes. Regulation of this superfamily of receptors is controlled by GPCR kinases…”
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The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2 by Bao, Lei, Festa, Fernanda, Freet, Christopher S., Lee, John P., Hirschler-Laszkiewicz, Iwona M., Chen, Shu-jen, Keefer, Kerry A., Wang, Hong-Gang, Patterson, Andrew D., Cheung, Joseph Y., Miller, Barbara A.

“…Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an essential role in protecting cell viability through modulation of oxidative…”
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Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors by Bouley, Renee, Waldschmidt, Helen V, Cato, M Claire, Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y, Yao, Xin-Qiu, Koch, Walter J, Larsen, Scott D, Tesmer, John J G

“…G protein-coupled receptor kinases (GRKs) phosphorylate activated receptors to promote arrestin binding, decoupling from heterotrimeric G proteins, and…”
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Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance by Hoffman, Nicholas E, Miller, Barbara A, Wang, JuFang, Elrod, John W, Rajan, Sudasan, Gao, Erhe, Song, Jianliang, Zhang, Xue-Qian, Hirschler-Laszkiewicz, Iwona, Shanmughapriya, Santhanam, Koch, Walter J, Feldman, Arthur M, Madesh, Muniswamy, Cheung, Joseph Y

“…Ubiquitously expressed Trpm2 channel limits oxidative stress and preserves mitochondrial function. We first demonstrated that intracellular Ca(2+)…”
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Role of TRPM2 in cell proliferation and susceptibility to oxidative stress by Chen, Shu-jen, Zhang, Wenyi, Tong, Qin, Conrad, Kathleen, Hirschler-Laszkiewicz, Iwona, Bayerl, Michael, Kim, Jason K, Cheung, Joseph Y, Miller, Barbara A

“…The transient receptor potential (TRP) channel TRPM2 is an ion channel that modulates cell survival. We report here that full-length (TRPM2-L) and short…”
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Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity by Chan, Tung O, Zhang, Jin, Rodeck, Ulrich, Pascal, John M, Armen, Roger S, Spring, Maureen, Dumitru, Calin D, Myers, Valerie, Li, Xue, Cheung, Joseph Y, Feldman, Arthur M

“…Phosphorylation of a threonine residue (T308 in Akt1) in the activation loop of Akt kinases is a prerequisite for deregulated Akt activity frequently observed…”
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The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury by Miller, Barbara A, Wang, JuFang, Hirschler-Laszkiewicz, Iwona, Gao, Erhe, Song, Jianliang, Zhang, Xue-Qian, Koch, Walter J, Madesh, Muniswamy, Mallilankaraman, Karthik, Gu, Tongda, Chen, Shu-jen, Keefer, Kerry, Conrad, Kathleen, Feldman, Arthur M, Cheung, Joseph Y

“…The second member of the transient receptor potential-melastatin channel family (TRPM2) is expressed in the heart and vasculature. TRPM2 channels were…”
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Mitochondrial dysfunction in human immunodeficiency virus‐1 transgenic mouse cardiac myocytes by Cheung, Joseph Y., Gordon, Jennifer, Wang, JuFang, Song, Jianliang, Zhang, Xue‐Qian, Prado, Fabian Jana, Shanmughapriya, Santhanam, Rajan, Sudarsan, Tomar, Dhanendra, Tahrir, Farzaneh G., Gupta, Manish K., Knezevic, Tijana, Merabova, Nana, Kontos, Christopher D., McClung, Joseph M., Klotman, Paul E., Madesh, Muniswamy, Khalili, Kamel, Feldman, Arthur M.

“…The pathophysiology of human immunodeficiency virus (HIV)‐associated cardiomyopathy remains uncertain. We used HIV‐1 transgenic (Tg26) mice to explore…”
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