Search Results - "Cheung, Jeanne"

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice by Lau, Janet, Cheung, Jeanne, Navarro, Armando, Lianoglou, Steve, Haley, Benjamin, Totpal, Klara, Sanders, Laura, Koeppen, Hartmut, Caplazi, Patrick, McBride, Jacqueline, Chiu, Henry, Hong, Rebecca, Grogan, Jane, Javinal, Vincent, Yauch, Robert, Irving, Bryan, Belvin, Marcia, Mellman, Ira, Kim, Jeong M., Schmidt, Maike

“…Expression of PD-L1, the ligand for T-cell inhibitory receptor PD-1, is one key immunosuppressive mechanism by which cancer avoids eradication by the immune…”
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Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy by Cubas, Rafael, Khan, Zia, Gong, Qian, Moskalenko, Marina, Xiong, Huizhong, Ou, Qinglin, Pai, Christine, Rodriguez, Ryan, Cheung, Jeanne, Chan, Andrew C

“…BackgroundCancer immunotherapy has evolved from interferon-alpha (IFNα) and interleukin-2 in the 1980s to CTLA-4 and PD-1/PD-L1 checkpoint inhibitors (CPIs),…”
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A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R by Parham, Christi, Chirica, Madaline, Timans, Jacqueline, Vaisberg, Elena, Travis, Marilyn, Cheung, Jeanne, Pflanz, Stefan, Zhang, Rebecca, Singh, Komal P., Vega, Felix, To, Wayne, Wagner, Janet, O’Farrell, Anne-Marie, McClanahan, Terrill, Zurawski, Sandra, Hannum, Charles, Gorman, Daniel, Rennick, Donna M., Kastelein, Robert A., de Waal Malefyt, Rene, Moore, Kevin W.

“…Abstract IL-23 is a heterodimeric cytokine composed of the IL-12p40 “soluble receptor” subunit and a novel cytokine-like subunit related to IL-12p35, termed…”
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Role of PD-1 during effector CD8 T cell differentiation by Ahn, Eunseon, Araki, Koichi, Hashimoto, Masao, Li, Weiyan, Riley, James L., Cheung, Jeanne, Sharpe, Arlene H., Freeman, Gordon J., Irving, Bryan A., Ahmed, Rafi

“…PD-1 (programmed cell death-1) is the central inhibitory receptor regulating CD8 T cell exhaustion during chronic viral infection and cancer. Interestingly,…”
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T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition by Hui, Enfu, Cheung, Jeanne, Zhu, Jing, Su, Xiaolei, Taylor, Marcus J., Wallweber, Heidi A., Sasmal, Dibyendu K., Huang, Jun, Kim, Jeong M., Mellman, Ira, Vale, Ronald D.

“…Programmed cell death–1 (PD-1) is a coinhibitory receptor that suppresses T cell activation and is an important cancer immunotherapy target. Upon activation by…”
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MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade by Ebert, Peter J.R., Cheung, Jeanne, Yang, Yagai, McNamara, Erin, Hong, Rebecca, Moskalenko, Marina, Gould, Stephen E., Maecker, Heather, Irving, Bryan A., Kim, Jeong M., Belvin, Marcia, Mellman, Ira

“…Targeted inhibition of mitogen-activated protein kinase (MAPK) kinase (MEK) can induce regression of tumors bearing activating mutations in the Ras pathway but…”
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PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer by Oh, Soyoung A, Wu, Dai-Chen, Cheung, Jeanne, Navarro, Armando, Xiong, Huizhong, Cubas, Rafael, Totpal, Klara, Chiu, Henry, Wu, Yan, Comps-Agrar, Laetitia, Leader, Andrew M, Merad, Miriam, Roose-Germa, Merone, Warming, Soren, Yan, Minhong, Kim, Jeong M, Rutz, Sascha, Mellman, Ira

“…Inhibiting the programmed death-1 (PD-1) pathway is one of the most effective approaches to cancer immunotherapy, but its mechanistic basis remains…”
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Chemotherapy Combines Effectively with Anti-PD-L1 Treatment and Can Augment Antitumor Responses by Cubas, Rafael, Moskalenko, Marina, Cheung, Jeanne, Yang, Michelle, McNamara, Erin, Xiong, Huizhong, Hoves, Sabine, Ries, Carola H, Kim, Jeong, Gould, Stephen

“…Immunotherapy with checkpoint inhibitors has proved to be highly effective, with durable responses in a subset of patients. Given their encouraging clinical…”
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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6 by Yen, David, Cheung, Jeanne, Scheerens, Heleen, Poulet, Frédérique, McClanahan, Terrill, McKenzie, Brent, Kleinschek, Melanie A, Owyang, Alex, Mattson, Jeanine, Blumenschein, Wendy, Murphy, Erin, Sathe, Manjiri, Cua, Daniel J, Kastelein, Robert A, Rennick, Donna

“…Uncontrolled mucosal immunity in the gastrointestinal tract of humans results in chronic inflammatory bowel disease (IBD), such as Crohn disease and ulcerative…”
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Abstract 4898: Effects of chemotherapeutic agents on the tumor immune microenvironment by Belvin, Marcia P., Luoh, Shiuh-Ming, Cheung, Jeanne, McNamara, Erin, Cubas, Rafael, Kim, Jeong

“…Abstract Immunotherapeutic agents have shown dramatic success in oncology in recent years and several have been approved in melanoma and lung cancer. One…”
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IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo by Fort, Madeline M., Cheung, Jeanne, Yen, David, Li, Joana, Zurawski, Sandra M., Lo, Sylvia, Menon, Satish, Clifford, Teresa, Hunte, Brisdell, Lesley, Robin, Muchamuel, Tony, Hurst, Stephen D., Zurawski, Gerard, Leach, Michael W., Gorman, Daniel M., Rennick, Donna M.

“…We have characterized a cytokine produced by Th2 cells, designated as IL-25. Infusion of mice with IL-25 induced IL-4, IL-5, and IL-13 gene expression. The…”
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Abstract 4905: Effects of MAPK pathway inhibitors in the tumor immune microenvironment by Belvin, Marcia P., Williams, Erin, Luoh, Shiuh-Ming, Cheung, Jeanne, Orr, Christine, Chan, Emily, Ebert, Peter, Mellman, Ira, Kim, Jeong, Merchant, Mark

“…Abstract Immunotherapeutic agents have shown great promise in the clinic in recent years and this has led to their approval as single agents or as immune…”
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MAP kinase inhibitors stimulate T cell and anti-tumor activity in combination with blockade of the PD-L1/PD-1 interaction by Irving, Bryan A, Cheung, Jeanne, Yang, Yagai, Moskalenka, Marina, Kowanetz, Marcin, Maecker, Heather, Mellman, Ira

“…Pharmacological inhibition of the MAPK pathway with MEK or BRAF antagonists has proved successful in inducing regression of melanoma tumors bearing the…”
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Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush ( Larrea tridentata) by Luo, Jian, Chuang, Tom, Cheung, Jeanne, Quan, Josephine, Tsai, Joyce, Sullivan, Cynthia, Hector, Richard F, Reed, Michael J, Meszaros, Karl, King, Steven R, Carlson, Thomas J, Reaven, Gerald M

“…An ethnomedically-driven approach was used to evaluate the ability of a pure compound isolated from the creosote bush ( Larrea tridentata) to lower plasma…”
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Novel terpenoid-type quinones isolated from Pycnanthus angolensis of potential utility in the treatment of type 2 diabetes by Luo, J, Cheung, J, Yevich, E M, Clark, J P, Tsai, J, Lapresca, P, Ubillas, R P, Fort, D M, Carlson, T J, Hector, R F, King, S R, Mendez, C D, Jolad, S D, Reaven, G M

“…Using an ethnomedical-based drug discovery program, two previously unknown compounds (SP-18904 and SP-18905) from Pycnanthus angolensis were isolated that…”
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IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4 + T Cells by Pflanz, Stefan, Timans, Jackie C, Cheung, Jeanne, Rosales, Rency, Kanzler, Holger, Gilbert, Jonathan, Hibbert, Linda, Churakova, Tatyana, Travis, Marilyn, Vaisberg, Elena, Blumenschein, Wendy M, Mattson, Jeanine D, Wagner, Janet L, To, Wayne, Zurawski, Sandra, McClanahan, Terrill K, Gorman, Daniel M, Bazan, J.Fernando, de Waal Malefyt, Rene, Rennick, Donna, Kastelein, Robert A

“…An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated…”
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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R by Parham, Christi, Chirica, Madaline, Timans, Jacqueline, Vaisberg, Elena, Travis, Marilyn, Cheung, Jeanne, Pflanz, Stefan, Zhang, Rebecca, Singh, Komal P, Vega, Felix, To, Wayne, Wagner, Janet, O'Farrell, Anne-Marie, McClanahan, Terrill, Zurawski, Sandra, Hannum, Charles, Gorman, Daniel, Rennick, Donna M, Kastelein, Robert A, de Waal Malefyt, Rene, Moore, Kevin W

“…IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human…”
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A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12R{beta}1 and a Novel Cytokine Receptor Subunit, IL-23R by Parham, Christi, Chirica, Madaline, Timans, Jacqueline, Vaisberg, Elena, Travis, Marilyn, Cheung, Jeanne, Pflanz, Stefan, Zhang, Rebecca, Singh, Komal P, Vega, Felix, To, Wayne, Wagner, Janet, O'Farrell, Anne-Marie, McClanahan, Terrill, Zurawski, Sandra, Hannum, Charles, Gorman, Daniel, Rennick, Donna M, Kastelein, Robert A, de Waal Malefyt, Rene, Moore, Kevin W

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