Search Results - "Cheung, Iris"

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex by Cheung, Iris, Shulha, Hennady P, Jiang, Yan, Matevossian, Anouch, Wang, Jie, Weng, Zhiping, Akbarian, Schahram

“…Little is known about the regulation of neuronal and other cell-type specific epigenomes from the brain. Here, we map the genome-wide distribution of…”
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Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory by Jakovcevski, Mira, Ruan, Hongyu, Shen, Erica Y, Dincer, Aslihan, Javidfar, Behnam, Ma, Qi, Peter, Cyril J, Cheung, Iris, Mitchell, Amanda C, Jiang, Yan, Lin, Cong L, Pothula, Venu, Stewart, A Francis, Ernst, Patricia, Yao, Wei-Dong, Akbarian, Schahram

“…Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular…”
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Coordinated cell type-specific epigenetic remodeling in prefrontal cortex begins before birth and continues into early adulthood by Shulha, Hennady P, Cheung, Iris, Guo, Yin, Akbarian, Schahram, Weng, Zhiping

“…Development of prefrontal and other higher-order association cortices is associated with widespread changes in the cortical transcriptome, particularly during…”
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Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice by Shen, Erica Y., Ahern, Todd H., Cheung, Iris, Straubhaar, Juerg, Dincer, Aslihan, Houston, Isaac, de Vries, Geert J., Akbarian, Schahram, Forger, Nancy G.

“…Many neurological and psychiatric disorders exhibit gender disparities, and sex differences in the brain likely explain some of these effects. Recent work in…”
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Methods for detailed energy data collection of miscellaneous and electronic loads in a commercial office building by Lanzisera, Steven, Dawson-Haggerty, Stephen, Cheung, H.Y. Iris, Taneja, Jay, Culler, David, Brown, Richard

“…Miscellaneous and electronic loads (MELs) consume about 20% of the primary energy used in U.S. buildings, and this share is projected to increase for the…”
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Human-specific histone methylation signatures at transcription start sites in prefrontal neurons by Shulha, Hennady P, Crisci, Jessica L, Reshetov, Denis, Tushir, Jogender S, Cheung, Iris, Bharadwaj, Rahul, Chou, Hsin-Jung, Houston, Isaac B, Peter, Cyril J, Mitchell, Amanda C, Yao, Wei-Dong, Myers, Richard H, Chen, Jiang-Fan, Preuss, Todd M, Rogaev, Evgeny I, Jensen, Jeffrey D, Weng, Zhiping, Akbarian, Schahram

“…Cognitive abilities and disorders unique to humans are thought to result from adaptively driven changes in brain transcriptomes, but little is known about the…”
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Structure and molecular organization of mammalian fatty acid synthase by Asturias, Francisco J, Chadick, James Z, Cheung, Iris K, Stark, Helga, Witkowski, Andrzej, Joshi, Anil K, Smith, Stuart

“…De novo synthesis of fatty acids in the cytosol of animal cells is carried out by the multifunctional, homodimeric fatty acid synthase (FAS). Cryo-EM analysis…”
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Harnessing power of simulation training effectiveness with Kirkpatrick model in emergency surgical airway procedures by Chia, Nam-Hung, Cheung, Victor Kai-Lam, Lam, Madeleine Lok-Yee, Cheung, Iris Wai-Kwan, Wong, Taurus Kwun-Yip, So, Sze-Sze, So, Eric Hang-Kwong, Ng, George Wing-Yiu

“…Training effectiveness indicates how good a program has met pre-set training objectives or organizational goals for the best benefit of healthcare…”
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Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy by Asturias, Francisco J, Cheung, Iris K, Sabouri, Nasim, Chilkova, Olga, Wepplo, Daniel, Johansson, Erik

“…The structure of the multisubunit yeast DNA polymerase epsilon (Pol epsilon) was determined to 20-A resolution using cryo-EM and single-particle image…”
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Energy savings assessment for digital-to-analog converter boxes by Cheung, Hoi Ying (Iris), Meier, Alan, Brown, Richard

“…The Digital Television (DTV) Converter Box Coupon Program was administered by the U.S. government to subsidize purchases of digital-to-analog converter boxes,…”
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A simple method for improving the specificity of anti-methyl histone antibodies by Connor, Caroline, Cheung, Iris, Simon, Andrew, Jakovcevski, Mira, Weng, Zhiping, Akbarian, Schahram

“…Antibodies differentiating between the mono-, di- and trimethylated forms of specific histone lysine residues are a critical tool in epigenome research, but…”
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SUMOylation regulates telomere length homeostasis by targeting Cdc13 by Zhao, Xiaolan, Hang, Lisa E, Liu, Xianpeng, Cheung, Iris, Yang, Yan

“…Cdc13 forms a complex with Stn1-Ten1 that caps budding yeast telomeres; Cdc13 also recruits the telomerase complex. Indeed, Cdk1 phosphorylates Cdc13 and this…”
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Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains by Bai, Guang, Cheung, Iris, Shulha, Hennady P, Coelho, Joana E, Li, Ping, Dong, Xianjun, Jakovcevski, Mira, Wang, Yumei, Grigorenko, Anastasia, Jiang, Yan, Hoss, Andrew, Patel, Krupal, Zheng, Ming, Rogaev, Evgeny, Myers, Richard H, Weng, Zhiping, Akbarian, Schahram, Chen, Jiang-Fan

“…To investigate epigenetic contributions to Huntington's disease (HD) pathogenesis, we carried out genome-wide mapping of the transcriptional mark,…”
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Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA by Lansdorp, Peter M, Cheung, Iris, Schertzer, Michael, Rose, Ann

“…Genetic integrity is crucial to normal cell function, and mutations in genes required for DNA replication and repair underlie various forms of genetic…”
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Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory by Jakovcevski, Mira, Ruan, Hongyu, Shen, Erica Y, Dincer, Aslihan, Javidfar, Behnam, Ma, Qi, Peter, Cyril J, Cheung, Iris, Mitchell, Amanda C, Jiang, Yan

“…Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular…”
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Coordinated Cell Type-Specific Epigenetic Remodeling in Prefrontal Cortex Begins before Birth and Continues into Early Adulthood: e1003433 by Shulha, Hennady P, Cheung, Iris, Guo, Yin, Akbarian, Schahram, Weng, Zhiping

“…Development of prefrontal and other higher-order association cortices is associated with widespread changes in the cortical transcriptome, particularly during…”
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N-terminus oligomerization regulates the function of cardiac ryanodine receptors by Zissimopoulos, Spyros, Viero, Cedric, Seidel, Monika, Cumbes, Bevan, White, Judith, Cheung, Iris, Stewart, Richard, Jeyakumar, Loice H, Fleischer, Sidney, Mukherjee, Saptarshi, Thomas, N Lowri, Williams, Alan J, Lai, F Anthony

“…The ryanodine receptor (RyR) is an ion channel composed of four identical subunits mediating calcium efflux from the endo/sarcoplasmic reticulum of excitable…”
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Amino-terminus oligomerization regulates cardiac ryanodine receptor function by Zissimopoulos, Spyros, Viero, Cedric, Seidel, Monika, Cumbes, Bevan, White, Judith, Cheung, Iris, Stewart, Richard, Jeyakumar, Loice H., Fleischer, Sidney, Mukherjee, Saptarshi, Thomas, N. Lowri, Williams, Alan J., Lai, F. Anthony

“…The ryanodine receptor (RyR) is an ion channel composed of four identical subunits mediating calcium efflux from the endo/sarcoplasmic reticulum of excitable…”
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RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder by Huang, Hsien-Sung, Cheung, Iris, Akbarian, Schahram

“…Dysfunction of cerebral cortex in autism is thought to involve alterations in inhibitory neurotransmission. Here, we screened, in prefrontal cortex (PFC) of 15…”
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High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans by Cheung, Iris, Schertzer, Michael, Rose, Ann, Lansdorp, Peter M.

“…Telomerase is essential to maintain telomere length in most eukaryotes. Other functions for telomerase have been proposed but molecular mechanisms remain…”
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