Search Results - "Cheung, Hoi Yin"
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Quantitative proteomics in lung cancer
Published in Journal of biomedical science (14-06-2017)“…Lung cancer is the most common cause of cancer-related death worldwide, less than 7% of patients survive 10 years following diagnosis across all stages of lung…”
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MCM2-regulated functional networks in lung cancer by multi-dimensional proteomic approach
Published in Scientific reports (16-10-2017)“…DNA replication control is vital for maintaining genome stability and the cell cycle, perhaps most notably during cell division. Malignancies often exhibit…”
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Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism
Published in Advanced science (01-10-2020)“…Extracellular particles (EPs) including extracellular vesicles (EVs) and exomeres play significant roles in diseases and therapeutic applications. However,…”
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ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer
Published in Journal of biomedical science (23-06-2020)“…Abstract Background ZNF322A is an oncogenic transcription factor that belongs to the Cys2His2-type zinc-finger protein family. Accumulating evidence suggests…”
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DUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
Published in Cell death discovery (14-06-2024)“…DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our…”
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Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy
Published in Cell death & disease (17-10-2019)“…MYCN -amplified (MNA) neuroblastoma is an aggressive neural crest-derived pediatric cancer. However, MYCN is indispensable for development and…”
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Tissue Stabilization, Bacterial Adhesion, and Stem Cell Viability in Trans-cinnamaldehyde-conditioned Dentin
Published in Journal of endodontics (01-12-2023)“…INTRODUCTIONThis laboratory study aimed to evaluate the effect of trans-cinnamaldehyde (TC) conditioning on dentin tissue stabilization, bacterial adhesion,…”
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Sphingosine‐1‐Phosphate Receptor‐3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche
Published in Stem cells (Dayton, Ohio) (01-04-2017)“…Hematopoietic stem and progenitor cells (HSPCs) egress from bone marrow (BM) during homeostasis and at increased rates during stress; however, the mechanisms…”
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Multiomics Reveals Induction of Neuroblastoma SK-N-BE(2)C Cell Death by Mitochondrial Division Inhibitor 1 through Multiple Effects
Published in Journal of proteome research (05-01-2024)“…Mitochondrial division inhibitor 1 (Mdivi-1) is a well-known synthetic compound aimed at inhibiting dynamin-related protein 1 (Drp1) to suppress mitochondrial…”
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Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice
Published in Cell reports (Cambridge) (23-11-2021)“…Strengthening the gut epithelial barrier is a potential strategy for management of gut microbiota-associated illnesses. Here, we demonstrate that…”
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Phosphoproteome Analysis Reveals Dynamic Heat Shock Protein 27 Phosphorylation in Tanshinone IIA-Induced Cell Death
Published in Journal of proteome research (03-04-2020)“…Gastric cancer is one of the most common types of cancer worldwide. Nevertheless, effective therapeutic strategies have not yet been discovered. Several…”
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Quantitative Proteomics of Th-MYCN Transgenic Mice Reveals Aurora Kinase Inhibitor Altered Metabolic Pathways and Enhanced ACADM To Suppress Neuroblastoma Progression
Published in Journal of proteome research (01-11-2019)“…Neuroblastoma is a neural crest-derived embryonal tumor and accounts for about 15% of all cancer deaths in children. MYCN amplification is associated with…”
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Abstract 1043: Identification of the novel immune synapse-localized proteome for immuno-oncology using Microscoop-induced targeted photo-biotinylation
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Although tens of immune synapse (IS) protein species are known, there remain many unknown IS-localized protein species. Understanding the proteome of…”
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Abstract 5638: Total-sync ultra-content microscopic opto-biotinylation enables high-sensitivity hypothesis-free subcellular protein discovery
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract High-sensitivity hypothesis-free subcellular proteomics is challenging due to the limited sensitivity of mass spectrometry and the lack of…”
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Novel Utilization of Terminators in the Design of Biologically Adjustable Synthetic Filters
Published in ACS synthetic biology (20-05-2016)“…Terminators, which signal the end of transcription processes, are typically placed behind the last coding sequence of an operon to prevent interference between…”
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