Search Results - "Cheung, Dorothy"

Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial by Kelsen, Steven G., Agache, Ioana O., Soong, Weily, Israel, Elliot, Chupp, Geoffrey L., Cheung, Dorothy S., Theess, Wiebke, Yang, Xiaoying, Staton, Tracy L., Choy, David F., Fong, Alice, Dash, Ajit, Dolton, Michael, Pappu, Rajita, Brightling, Christopher E.

“…The IL-33/ST2 pathway is linked with asthma susceptibility. Inhaled allergens, pollutants, and respiratory viruses, which trigger asthma exacerbations, induce…”
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Phase 2 randomized clinical trial of astegolimab in patients with moderate to severe atopic dermatitis by Maurer, Marcus, Cheung, Dorothy S., Theess, Wiebke, Yang, Xiaoying, Dolton, Michael, Guttman, Anna, Choy, David F., Dash, Ajit, Grimbaldeston, Michele A., Soong, Weily

“…The binding of IL-33 to its receptor ST2 (alias of IL1RL1) leads to the release of inflammatory mediators and may play a role in the pathogenesis of atopic…”
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Intestinal Microbiota Disruption Reduces Regulatory T Cells and Increases Respiratory Viral Infection Mortality Through Increased IFNγ Production by Grayson, Mitchell H, Camarda, Lauren E, Hussain, Syed-Rehan A, Zemple, Sarah J, Hayward, Michael, Lam, Vy, Hunter, Desiré A, Santoro, Jennifer L, Rohlfing, Michelle, Cheung, Dorothy S, Salzman, Nita H

“…Alterations in gastrointestinal microbiota indirectly modulate the risk of atopic disease, but effects on respiratory viral infections are less clear. Using…”
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Astegolimab, an anti-ST2, in chronic obstructive pulmonary disease (COPD-ST2OP): a phase 2a, placebo-controlled trial by Yousuf, Ahmed J, Mohammed, Seid, Carr, Liesl, Yavari Ramsheh, Mohammadali, Micieli, Claudia, Mistry, Vijay, Haldar, Kairobi, Wright, Adam, Novotny, Petr, Parker, Sarah, Glover, Sarah, Finch, Joanne, Quann, Niamh, Brookes, Cassandra L, Hobson, Rachel, Ibrahim, Wadah, Russell, Richard J, John, Catherine, Grimbaldeston, Michele A, Choy, David F, Cheung, Dorothy, Steiner, Michael, Greening, Neil J, Brightling, Christopher E

“…Chronic obstructive pulmonary disease (COPD) is a heterogeneous inflammatory airway disease. The epithelial-derived IL-33 and its receptor ST2 have been…”
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Cysteinyl leukotriene receptor 1 expression identifies a subset of neutrophils during the antiviral response that contributes to postviral atopic airway disease by Cheung, Dorothy S., Sigua, Jerome A., Simpson, Pippa M., Yan, Ke, Hussain, Syed-Rehan A., Santoro, Jennifer L., Buell, Erika J., Hunter, Desire A., Rohlfing, Michelle, Patadia, Deepa, Grayson, Mitchell H.

“…Viral respiratory tract infections increase the risk of development and exacerbation of atopic disease. Previously, we demonstrated the requirement for a…”
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Oxidative Burst Defines Differences in Respiratory Virus Associated Neutrophil Subtypes by Rohlfing, Michelle, Cheung, Dorothy S., MD, FAAAAI, Grayson, Mitchell H., MD, FAAAAI

“…In the Sendai virus (SeV) model of post-viral atopic disease, we demonstrated a critical need for CD49d+ PMN driving disease development…”
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A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk by Chang, Diana, Hunkapiller, Julie, Bhangale, Tushar, Reeder, Jens, Mukhyala, Kiran, Tom, Jennifer, Cowgill, Amy, Vogel, Jan, Forrest, William F., Khan, Zia, Stockwell, Amy, McCarthy, Mark I., Staton, Tracy L., Olsson, Julie, Holweg, Cecile T. J., Cheung, Dorothy S., Chen, Hubert, Brauer, Matthew J., Graham, Robert R., Behrens, Timothy, Wilson, Mark S., Arron, Joseph R., Choy, David F., Yaspan, Brian L.

“…Genome-wide association studies (GWAS) have identified many common variant loci associated with asthma susceptibility, but few studies investigate the genetics…”
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CD49d-expressing neutrophils differentiate atopic from nonatopic individuals by Sigua, Jerome A., MD, Buelow, Becky, MD, Cheung, Dorothy S., MD, Buell, Erika, BS, Hunter, Desire, BS, Klancnik, Meribeth, MLT, Grayson, Mitchell H., MD

“…Several epidemiologic studies have demonstrated that severe respiratory viral infections markedly increase the risk of atopic disease including asthma.1,2 By…”
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Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children by Vasudev, Monica, Cheung, Dorothy S, Pincsak, Hannah, Li, Shun-Hwa, Yan, Ke, Simpson, Pippa, Dasu, Trivikram, Grayson, Mitchell H

“…In a mouse model of viral induced atopic disease, expression of FcεRI on dendritic cells is critical. While adult human conventional (cDC) and plasmacytoid…”
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A survivor: The eosinophil as a regulator in asthma by Cheung, Dorothy S., MD, Grayson, Mitchell H., MD

“…Because Takeda et al7 transferred bone marrow cells into PHIL mice before any ovalbumin sensitization or challenge, it remains unknown whether the…”
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Effect of TREM1 Deficiency in Post-Viral Induced Atopic Disease by Cheung, Dorothy S., MD, FAAAAI, Buell, Erika, Grayson, Mitchell H., MD, FAAAAI

“…Rationale Using the Sendai virus (SeV) post-viral atopic disease model, we have shown that a subset of CD49d expressing neutrophils (CD49d+ PMN) is critical…”
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Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia by Grayson, Mitchell H, Cheung, Dorothy, Rohlfing, Michelle M, Kitchens, Robert, Spiegel, Daniel E, Tucker, Jennifer, Battaile, John T, Alevy, Yael, Yan, Le, Agapov, Eugene, Kim, Edy Y, Holtzman, Michael J

“…Respiratory viral infections are associated with an increased risk of asthma, but how acute Th1 antiviral immune responses lead to chronic inflammatory Th2…”
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Epigenetic and transcriptional determinants of the human breast by Gascard, Philippe, Bilenky, Misha, Sigaroudinia, Mahvash, Zhao, Jianxin, Li, Luolan, Carles, Annaick, Delaney, Allen, Tam, Angela, Kamoh, Baljit, Cho, Stephanie, Griffith, Malachi, Chu, Andy, Robertson, Gordon, Cheung, Dorothy, Li, Irene, Heravi-Moussavi, Alireza, Moksa, Michelle, Mingay, Matthew, Hussainkhel, Angela, Davis, Brad, Nagarajan, Raman P., Hong, Chibo, Echipare, Lorigail, O’Geen, Henriette, Hangauer, Matthew J., Cheng, Jeffrey B., Neel, Dana, Hu, Donglei, McManus, Michael T., Moore, Richard, Mungall, Andrew, Ma, Yussanne, Plettner, Patrick, Ziv, Elad, Wang, Ting, Farnham, Peggy J., Jones, Steven J.M., Marra, Marco A., Tlsty, Thea D., Costello, Joseph F., Hirst, Martin

“…While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known…”
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The effectiveness of video-based exercise training program for people with intellectual disability: a multicenter study by Kwan, Rachel, Szeto, Grace, Ho, Ester, Wu, Annie, Wong, Lavinia, Ho, Gilbert, Lau, Rufina, Wong, Eyckle, Kwok, Anthony, Cheung, Dorothy

“…To examine the effectiveness of a specially designed video-based exercise program in promoting physical and balance performance in people with intellectual…”
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Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases by Zou, Yixuan, Hou, Xuefeng, Anegondi, Neha, Negahdar, Mohammadreza, Cheung, Dorothy, Belloni, Paula, de Crespigny, Alex, Coimbra, Alexandre Fernandez

“…Background Identifying systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF) patients at risk of more rapid forced vital capacity (FVC) decline…”
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Functional Phenotype Of CD49d-Expressing Neutrophils Differs Between Viral Infection and TLR Stimulation by Cheung, Dorothy S., Dr, Buell, Erika, Hunter, Desire, Mrs, Grayson, Mitchell H., Dr

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Acute Systemic Reduction in Regulatory T Cells Is Associated with Atopic Airway Disease by Reichert, Heather, Buell, Erika, Cheung, Dorothy S., MD, FAAAAI, Grayson, Mitchell H., MD, FAAAAI

“…The effect of on acute drop in Treg cell numbers on T cell skewing and mucous cell metaplasia was determined…”
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Role of Viruses in the Development of Atopic Disease in Pediatric Patients by Cheung, Dorothy S., Grayson, Mitchell H.

“…The prevalence of atopic diseases continues to rise in modernized countries, without a clear explanation for this increase. One potential cause identified from…”
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CD49d-Expressing Neutrophils Are Found In The Nasal Lavage During An Acute Upper Respiratory Illness by Sigua, Jerome, Dr, Grayson, Mitchell H., Dr, Simpson, Pippa, Dr, Buell, Erika, Ms, Hunter, Desire, Mrs, Cheung, Dorothy S., Dr

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Cyclo-Oxygenase Inhibition Increases The Frequency Of CD49d+ Neutrophils In The Bronchoalveolar Lavage (BAL) During a Respiratory Viral Infection by Hass, Jennifer A., Ms, Buell, Erika, Ms, Hunter, Desire, Mrs, Cheung, Dorothy S., Dr, Grayson, Mitchell H., Dr

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