Search Results - "Cheung, Anthony T.W."

An Integrin Binding-defective Mutant of Insulin-like Growth Factor-1 (R36E/R37E IGF1) Acts as a Dominant-negative Antagonist of the IGF1 Receptor (IGF1R) and Suppresses Tumorigenesis but Still Binds to IGF1R by Fujita, Masaaki, Ieguchi, Katsuaki, Cedano-Prieto, Dora M., Fong, Andrew, Wilkerson, Charles, Chen, Jane Q., Wu, Mac, Lo, Su-Hao, Cheung, Anthony T.W., Wilson, Machelle D., Cardiff, Robert D., Borowsky, Alexander D., Takada, Yoko K., Takada, Yoshikazu

“…Insulin-like growth factor-1 (IGF1) is a major therapeutic target for cancer. We recently reported that IGF1 directly binds to integrins (αvβ3 and α6β4) and…”
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A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease by Kutlar, Abdullah, Ataga, Kenneth I., McMahon, Lillian, Howard, Joanna, Galacteros, Frederic, Hagar, Ward, Vichinsky, Elliott, Cheung, Anthony T.W., Matsui, Neil, Embury, Stephen H.

“…Abnormal blood flow accounts for most of the clinical morbidity of sickle cell disease (SCD) [1,2]. Most notably, occlusion of flow in the microvasculature…”
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Exchange transfusion therapy and its effects on real‐time microcirculation in pediatric sickle cell anemia patients by To, Wilson James, Miller, Joshua W., Miguelino, Maricel G., Li, Jiajing, Lin, Xin, Chen, Peter, Green, Ralph, Cheung, Anthony T.W.

“…Abstract only The goal of exchange transfusion therapy is to ameliorate vasoocclusion and improve tissue perfusion by removing sickled red blood cells and…”
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The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo by Embury, Stephen H., Matsui, Neil M., Ramanujam, Sahana, Mayadas, Tanya N., Noguchi, Constance T., Diwan, Bhalchandra A., Mohandas, Narla, Cheung, Anthony T.W.

“…Microvascular occlusion in sickle cell disease can be initiated by adhesion of sickle red blood cells (RBCs) to the endothelium. Our objective in this study…”
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Whole blood viscosity and microvascular abnormalities in Alzheimer's Disease by Smith, M Meighan, Chen, Peter C Y, Li, Chin-Shang, Ramanujam, Sahana, Cheung, Anthony T W

“…We hypothesized that abnormalities in hemorheologic parameters, including vessel diameter, flow velocity, and whole blood viscosity (WBV), would be present in…”
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Comparison of real‐time microvascular abnormalities in pediatric and adult sickle cell anemia patients by Cheung, Anthony T.W., Miller, Joshua W., Craig, Sarah M., To, Patricia L., Lin, Xin, Samarron, Sandra L., Chen, Peter C.Y., Zwerdling, Theodore, Wun, Ted, Li, Chin‐Shang, Green, Ralph

“…The conjunctival microcirculation in 14 pediatric and eight adult sickle cell anemia (SCA) patients was studied using computer‐assisted intravital microscopy…”
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Correlation of conjunctival microangiopathy with retinopathy in type-2 diabetes mellitus (T2DM) patients by To, Wilson J, Telander, David G, Lloyd, Maureen E, Chen, Peter C Y, Cheung, Anthony T W

“…We hypothesized that T2DM vasculopathy can be revealed and quantified in the bulbar conjunctiva prior to its pathologic presentation in the retina. Using…”
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Microvascular abnormalities in sickle cell disease: a computer-assisted intravital microscopy study by Cheung, Anthony T.W., Chen, Peter C.Y., Larkin, Edward C., Duong, Patricia L., Ramanujam, Sahana, Tablin, Fern, Wun, Ted

“…The conjunctival microcirculation of 18 homozygous sickle cell disease (SCD) patients during steady-state, painful crisis, and postcrisis conditions was…”
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Exchange transfusion therapy and its effects on real-time microcirculation in pediatric sickle cell anemia patients: an intravital microscopy study by Cheung, Anthony T W, Miller, Joshua W, Miguelino, Maricel G, To, Wilson J, Li, Jiajing, Lin, Xin, Chen, Peter C, Samarron, Sandra L, Wun, Ted, Zwerdling, Theodore, Green, Ralph

“…Periodic blood exchange transfusion is a treatment modality commonly used to manage pediatric sickle cell anemia at the University of California Davis Medical…”
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Correlation of microvascular abnormalities and endothelial dysfunction in Type-1 Diabetes Mellitus (T1DM): a real-time intravital microscopy study by Cheung, Anthony T W, Tomic, M Meighan Smith, Chen, Peter C Y, Miguelino, Eric, Li, Chin-Shang, Devaraj, Sridevi

“…We hypothesize that real-time in vivo microvascular abnormalities should correlate with biochemical markers of inflammation/endothelial dysfunction in T1DM…”
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Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model by Driessen, Bernd, Zarucco, Laura, Gunther, Robert A, Burns, Patrick M, Lamb, Stephen V, Vincent, Stella E, Boston, Ray A, Jahr, Jonathan S, Cheung, Anthony T. W

“…OBJECTIVE:To test the hypothesis that low-volume resuscitation with hemoglobin glutamer-200 improves hemodynamic function and tissue oxygenation, whereas…”
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Alzheimer's disease: more than amyloid by Chew, Stanley H, Meighan Smith Tomic, M, Cheung, Anthony T W

“…The etiology of Alzheimer's disease (AD) is inconclusive. Treatments targeting amyloid have largely been unsuccessful. There is increasing evidence that…”
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Improvements in diabetic microangiopathy after successful simultaneous pancreas-kidney transplantation : A computer-assisted intravital microscopy study on the conjunctival microcirculation by CHEUNG, A. T. W, PEREZ, R. V, CHEN, P. C. Y

“…A computer-assisted intravital microscopy technology has been developed to noninvasively and objectively study diabetic microangiopathy in the conjunctival…”
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Microvascular abnormalities in the bulbar conjunctiva of patients with type 2 diabetes mellitus by Cheung, A T, Ramanujam, S, Greer, D A, Kumagai, L F, Aoki, T T

“…To study and quantify microvascular abnormalities objectively in vivo in patients with type 2 diabetes mellitus (T2DM). The conjunctival microcirculation in 14…”
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In vivo blood flow abnormalities in the transgenic knockout sickle cell mouse by Embury, S H, Mohandas, N, Paszty, C, Cooper, P, Cheung, A T

“…The accepted importance of circulatory impairment to sickle cell anemia remains to be verified by in vivo experimentation. Intravital microscopy studies of…”
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Effects of Poloxamer 188 Treatment on Sickle Cell Vaso-occlusive Crisis: Computer-Assisted Intravital Microscopy Study by Cheung, Anthony T. W., Chan, Matthew S., Ramanujam, Sahana, Rangaswami, Arun, Curl, Kris, Franklin, Patricia, Wun, Ted

“…Nine patients with sickle cell disease (SCD) who were hospitalized at UC Davis Medical Center for vaso-occlusive crisis (VOC) were studied as part of a…”
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Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease by Cheung, Anthony T.W., Harmatz, Paul, Wun, Ted, Chen, Peter C.Y., Larkin, Edward C., Adams, Robert J., Vichinsky, Elliott P.

“…The Stroke Prevention Trial has confirmed that utilization of transcranial Doppler ultrasonography (TCD), which examines blood flow in large intracranial…”
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Microvascular Abnormalities in Pediatric Diabetic Patients by Cheung, Anthony T.W., Price, Amber R., Duong, Patricia L., Ramanujam, Sahana, Gut, Jana, Larkin, Edward C., Chen, Peter C.Y., Wilson, Darrell M.

“…Microvascular abnormalities are associated with and causative of the development of end-stage organ complications in adult diabetic patients. Whether the same…”
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The Effects of Hemoglobin Glutamer-200 (Bovine) on the Microcirculation in a Canine Hypovolemia Model: A Noninvasive Computer-Assisted Intravital Microscopy Study by Cheung, Anthony T. W., Jahr, Jonathan S., Driessen, Bernd, Duong, Patricia L., Chan, Matthew S., Lurie, Fedor, Golkaryeh, Mohammad S., Kullar, Ravjeet K., Gunther, Robert A.

“…We sought to correlate in vivo microvascular, systemic function, hemodynamic, and oxygenation changes in autologous shed blood (n = 4) and hemoglobin…”
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Regulation of new blood vessel growth into ischemic skeletal muscle by Bush, Ruth L., Pevec, William C., Ndoye, Assan, Cheung, Anthony T.W., Sasse, Joachim, Pearson, David N.

“…Purpose: In a rabbit model, transposition of a muscle pedicle flap to an ischemic hind limb has been shown to result in the development of new blood vessels…”
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