Search Results - "Cheung, Alvin"

Fangchinoline inhibits non-small cell lung cancer metastasis by reversing epithelial-mesenchymal transition and suppressing the cytosolic ROS-related Akt-mTOR signaling pathway by Chen, Bonan, Song, Yue, Zhan, Yujuan, Zhou, Shikun, Ke, Junzi, Ao, Weizhen, Zhang, Yigan, Liang, Qiqi, He, Minhui, Li, Shuhui, Xie, Fuda, Huang, Haonan, Chan, Wai Nok, Cheung, Alvin H.K., Ma, Brigette B.Y., Kang, Wei, To, Ka Fai, Xiao, Jianyong

“…Few drugs alleviate non-small cell lung cancer (NSCLC) metastasis effectively. Small molecular screening demonstrated that fangchinoline (Fan) reversed…”
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Cancer‐associated fibroblasts in nonsmall cell lung cancer: From molecular mechanisms to clinical implications by Wong, Kit Yee, Cheung, Alvin Ho‐Kwan, Chen, Bonan, Chan, Wai Nok, Yu, Jun, Lo, Kwok Wai, Kang, Wei, To, Ka Fai

“…Lung cancer is the common and leading cause of cancer death worldwide. The tumor microenvironment has been recognized to be instrumental in tumorigenesis. To…”
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RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis by Chen, Danyu, Ji, Fenfen, Zhou, Qiming, Cheung, Henley, Pan, Yasi, Lau, Harry Cheuk-Hay, Liang, Cong, Yang, Zhenjie, Huang, Pingmei, Wei, Qinyao, Cheung, Alvin Ho-Kwan, Kang, Wei, Chen, Huarong, Yu, Jun, Wong, Chi Chun

“…The N6-methyladenosine (m6A) RNA binding protein YTHDF1 is frequently overexpressed in colorectal cancer (CRC) and drives chemotherapeutic resistance. To…”
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Targeting YAP1/TAZ in nonsmall‐cell lung carcinoma: From molecular mechanisms to precision medicine by Mui, Chun Wai, Chan, Wai Nok, Chen, Bonan, Cheung, Alvin Ho‐Kwan, Yu, Jun, Lo, Kwok Wai, Ke, Huixing, Kang, Wei, To, Ka Fai

“…Accumulating evidence has underscored the importance of the Hippo‐YAP1 signaling in lung tissue homeostasis, whereas its deregulation induces tumorigenesis…”
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Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma by Song, Qian, Zhang, Xiang, Liu, Weixin, Wei, Hong, Liang, Wei, Zhou, Yunfei, Ding, Yanqiang, Ji, Fenfen, Ho-Kwan Cheung, Alvin, Wong, Nathalie, Yu, Jun

“…Recent studies have highlighted the role of the gut microbiota and their metabolites in non-alcoholic fatty liver disease-associated hepatocellular carcinoma…”
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Out of the cycle: Impact of cell cycle aberrations on cancer metabolism and metastasis by Cheung, Alvin Ho‐Kwan, Hui, Chris Ho‐Lam, Wong, Kit Yee, Liu, Xiaoli, Chen, Bonan, Kang, Wei, To, Ka Fai

“…The use of cell cycle inhibitors has necessitated a better understanding of the cell cycle in tumor biology to optimize the therapeutic approach. Cell cycle…”
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High Soluble Fiber Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites in Mice by Yang, Jia, Wei, Hong, Lin, Yufeng, Chu, Eagle S.H., Zhou, Yunfei, Gou, Hongyan, Guo, Shang, Lau, Harry C.H., Cheung, Alvin H.K., Chen, Huarong, To, Ka Fei, Sung, Joseph J.Y., Wang, Yong, Yu, Jun

“…Dietary fibers are mainly fermented by the gut microbiota, but their roles in colorectal cancer (CRC) are largely unclear. Here, we investigated the…”
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FOXP4 is a Direct YAP1 Target that Promotes Gastric Cancer Stemness and Drives Metastasis by Liu, Xiaoli, Chen, Bonan, Xie, Fuda, Wong, Kit Yee, Cheung, Alvin Ho-Kwan, Zhang, Jinglin, Wu, Qian, Fang, Canbin, Hu, Jintao, Wang, Shouyu, Xu, Dazhi, Chen, Jianwu, Wang, Yuzhi, Wong, Chi Chun, Chen, Huarong, Wu, William Ka Kei, Yu, Jun, Chan, Michael W Y, Tsang, Chi Man, Lo, Kwok Wai, Tse, Gary M K, To, Ka-Fai, Kang, Wei

“…The Hippo-YAP1 pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration. Dysregulation of Hippo-YAP1 signaling…”
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Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients by Zhao, Liuyang, Zhang, Xiang, Zhou, Yunfei, Fu, Kaili, Lau, Harry Cheuk-Hay, Chun, Tommy Wai-Yiu, Cheung, Alvin Ho-Kwan, Coker, Olabisi Oluwabukola, Wei, Hong, Wu, William Ka-Kei, Wong, Sunny Hei, Sung, Joseph Jao-Yiu, To, Ka Fai, Yu, Jun

“…Large-scale fecal shotgun metagenomic sequencing revealed the high abundance of Parvimonas micra in colorectal cancer (CRC) patients. We investigated the role…”
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Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways by Zhang, Jinglin, Chen, Bonan, Li, Hui, Wang, Yifei, Liu, Xiaoli, Wong, Kit Yee, Chan, Wai Nok, Chan, Aden KY, Cheung, Alvin HK, Leung, Kam Tong, Dong, Yujuan, Pan, Yi, Ke, Huixing, Liang, Li, Zhou, Zhaocai, Xiao, Jianyong, Wong, Chi Chun, Wu, William KK, Cheng, Alfred SL, Ma, Brigette BY, Yu, Jun, Lo, Kwok Wai, Kang, Wei

“…Colorectal cancer (CRC) is one of the most common cancers worldwide. The tumor microenvironment exerts crucial effects in driving CRC progression…”
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Latest development of liquid biopsy by Cheung, Alvin Ho-Kwan, Chow, Chit, To, Ka-Fai

“…Liquid biopsy provides the opportunity of detecting and analyzing cancer in various body fluids. In peripheral blood, apart from circulating cell free DNA,…”
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FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p by Zhang, Jinglin, Zhou, Yuhang, Huang, Tingting, Wu, Feng, Pan, Yi, Dong, Yujuan, Wang, Yan, Chan, Aden K. Y., Liu, Liping, Kwan, Johnny S. H., Cheung, Alvin H. K., Wong, Chi Chun, Lo, Angela K. F., Cheng, Alfred S. L., Yu, Jun, Lo, Kwok Wai, Kang, Wei, To, Ka Fai

“…Fibroblast growth factors (FGFs) and their receptors are significant components during fundamental cellular processes. FGF18 plays a distinctive role in…”
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Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside by Liu, Xiaoli, Wang, Yifei, Chen, Bonan, Chan, Wai Nok, Mui, Chun Wai, Cheung, Alvin H.K, Zhang, Jinglin, Wong, Kit Yee, Yu, Jun, Kang, Wei, To, Ka Fai

“…The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its…”
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STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker by Chen, Bonan, Chan, Wai Nok, Mui, Chun Wai, Liu, Xiaoli, Zhang, Jinglin, Wang, Yifei, Cheung, Alvin H K, Chan, Aden K Y, Chan, Ronald C K, Leung, Kam Tong, Dong, Yujuan, Pan, Yi, Ke, Huixing, Liang, Li, Zhou, Zhaocai, Wong, Chi Chun, Wu, William K K, Cheng, Alfred S L, Yu, Jun, Lo, Kwok Wai, To, Ka Fai, Kang, Wei

“…Keywords: STK3, Gastric cancer, Oncogene, Ras-MAPK signaling…”
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Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of db/db Mice by CHEUNG, Alvin K. H, FUNG, Maggie K. L, LO, Amy C. Y, LAM, Terence T. L, KWOK FAI SO, CHUNG, Stephen S. M, CHUNG, Sookja K

“…Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of db/db Mice Alvin K.H…”
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The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer by Wong, Chi Chun, Wu, Jian-Lin, Ji, Fenfen, Kang, Wei, Bian, Xiqing, Chen, Huarong, Chan, Lam-Shing, Luk, Simson Tsz Yat, Tong, Samuel, Xu, Jiaying, Zhou, Qiming, Liu, Dabin, Su, Hao, Gou, Hongyan, Cheung, Alvin Ho-Kwan, To, Ka Fai, Cai, Zongwei, Shay, Jerry W., Yu, Jun

“…Therapeutic targeting of KRAS -mutant colorectal cancer (CRC) is an unmet need. Here, we show that Proprotein Convertase Subtilisin/Kexin type 9 (PSCK9)…”
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SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis by Huang, Tingting, Zhou, Yuhang, Zhang, Jinglin, Wong, Chi Chun, Li, Weilin, Kwan, Johnny S. H., Yang, Rui, Chan, Aden K. Y., Dong, Yujuan, Wu, Feng, Zhang, Bin, Cheung, Alvin H. K., Wu, William K. K., Cheng, Alfred S. L., Yu, Jun, Wong, Nathalie, Kang, Wei, To, Ka Fai

“…Slit-Robo GTPase-activating protein 1 (SRGAP1) functions as a GAP for Rho-family GTPases and downstream of Slit-Robo signaling. We aim to investigate the…”
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The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer by Zhang, Jinglin, Chen, Bonan, Wang, Yifei, Liu, Xiaoli, Yan, Huan, Wong, Kit Yee, Chan, Aden KY, Cheung, Alvin HK, Chow, Chit, Xu, Dazhi, Wang, Shouyu, Huang, Bing, Liang, Li, Ke, Huixing, Wong, Chi Chun, Wu, William KK, Cheng, Alfred SL, Yu, Jun, Lo, Kwok Wai, To, Ka Fai, Kang, Wei

“…Homeobox genes include HOX and non‐HOX genes. HOX proteins play fundamental roles during ontogenesis by interacting with other non‐HOX gene‐encoded partners…”
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miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis by Kang, Wei, Huang, Tingting, Zhou, Yuhang, Zhang, Jinglin, Lung, Raymond W. M., Tong, Joanna H. M., Chan, Anthony W. H., Zhang, Bin, Wong, Chi Chun, Wu, Feng, Dong, Yujuan, Wang, Shiyan, Yang, Weiqin, Pan, Yi, Chak, Wing Po, Cheung, Alvin H. K., Pang, Jesse C. S., Yu, Jun, Cheng, Alfred S. L., To, Ka Fai

“…miR-375 is a tumor-suppressive microRNA (miRNA) in gastric cancer (GC). However, its molecular mechanism remains unclear. The aim of this study is to…”
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MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target by Wang, Yifei, Chen, Huarong, Liu, Weixin, Yan, Huan, Zhang, Yihan, Cheung, Alvin H.K., Zhang, Jinglin, Chen, Bonan, Liang, Li, Zhou, Zhaocai, Wong, Chi Chun, Wu, William K.K., Chan, Michael W.Y., Cheng, Alfred S.L., Ma, Brigette B.Y., Yu, Jun, Lo, Kwok Wai, To, Ka Fai, Kang, Wei

“…Rationale: Hyperactivation of Hippo-Yes-associated protein (YAP) signaling pathway governs tumorigenesis of gastric cancer (GC). Here we reveal that…”
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