Search Results - "Cheuk, Isabella"

Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness by Shin, Vivian Yvonne, Chen, Jiawei, Cheuk, Isabella Wai -Yin, Siu, Man-Ting, Ho, Chi-Wang, Wang, Xian, Jin, Hongchuan, Kwong, Ava

“…Triple-negative breast cancer (TNBC) is a malignant subtype of breast cancer with the absence of targeted therapy, resulting in poor prognosis in patients…”
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Acetylcholine receptors: Key players in cancer development by Chen, Jiawei, Cheuk, Isabella W.Y., Shin, Vivian Yvonne, Kwong, Ava

“…Acetylcholine (ACh) was first identified as a classic neuromodulator and transmit signals through two subgroups of receptors, namely muscarinic receptors…”
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Germline RECQL mutations in high risk Chinese breast cancer patients by Kwong, Ava, Shin, Vivian Y., Cheuk, Isabella W. Y., Chen, Jiawei, Au, Chun H., Ho, Dona N., Chan, Tsun L., Ma, Edmond S. K., Akbari, Mohammad R., Narod, Steven A.

“…Recently, RECQL was reported as a new breast cancer susceptibility gene. RECQL belongs to the RECQ DNA helicase family which unwinds double strand DNA and…”
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The Emerging Clinical Role of Spermine in Prostate Cancer by Peng, Qiang, Wong, Christine Yim-Ping, Cheuk, Isabella Wai-Yin, Teoh, Jeremy Yuen-Chun, Chiu, Peter Ka-Fung, Ng, Chi-Fai

“…Spermine, a member of polyamines, exists in all organisms and is essential for normal cell growth and function. It is highly expressed in the prostate compared…”
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Germline Mutation in 1338 BRCA-Negative Chinese Hereditary Breast and/or Ovarian Cancer Patients: Clinical Testing with a Multigene Test Panel by Kwong, Ava, Shin, Vivian Y, Chen, Jiawei, Cheuk, Isabella W Y, Ho, Cecilia Y S, Au, Chun H, Chan, Karen K L, Ngan, Hextan Y S, Chan, Tsun L, Ford, James M, Ma, Edmond S K

“…Differences in the mutation spectrum across ethnicities suggest the importance of identifying genes in addition to common high penetrant genes to estimate the…”
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Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma by Yuan, Chuang, Yip, Shea Ping, Wu, Vincent W C, Kwong, Dora L W, Cheuk, Isabella W Y, Ying, Michael

“…Radiotherapy (RT) of the neck is commonly given to nasopharyngeal carcinoma (NPC) patients for preventing cervical lymph node metastasis. However, neck RT may…”
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Functional Implications of Cathelicidin Antimicrobial Protein in Breast Cancer and Tumor-Associated Macrophage Microenvironment by Chen, Jiawei, Shin, Vivian Yvonne, Ho, John Chi-Wang, Siu, Man-Ting, Cheuk, Isabella Wai-Yin, Kwong, Ava

“…It is well-established that tumor-associated macrophages (TAMs) play an important role in breast cancer development. Accumulating evidence suggested that human…”
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Four complement factor H gene polymorphisms in association with AMD: A meta-analysis by Liao, Xuan, Lan, Chang-Jun, Cheuk, Isabella-Wai-Yin, Tan, Qing-qing

“…Highlights • To investigate the possible association between CFH gene polymorphisms and AMD risk. • Four polymorphisms of CFH −543G > A, A473A, −257C > T,…”
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Somatic mutation profiling in BRCA -negative breast and ovarian cancer patients by multigene panel sequencing by Kwong, Ava, Cheuk, Isabella Wy, Shin, Vivian Yvonne, Ho, Cecilia Ys, Au, Chun-Hang, Ho, Dona Ny, Wong, Elaine Yl, Yu, Stephanie Wy, Chen, Jiawei, Chan, Karen Kl, Ngan, Hextan Ys, Chan, Tsun-Leung, Ma, Edmond Sk

“…Targeted therapeutic agents such as poly (ADP-ribose) polymerases (PARP) inhibitors have emerged in treating cancers associated with germline mutations…”
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Association of EP2 receptor and SLC19A3 in regulating breast cancer metastasis by Cheuk, Isabella W, Shin, Vivian Y, Siu, Man T, Tsang, Julia Y, Ho, John C, Chen, Jiawei, Tse, Gary M, Wang, Xian, Kwong, Ava

“…Breast cancer is the most common cancer in women worldwide. Triple-negative breast cancer patients have higher metastatic rate than patients with other breast…”
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Detection of Methylated Circulating DNA as Noninvasive Biomarkers for Breast Cancer Diagnosis by Cheuk, Isabella Wai Yin, Shin, Vivian Yvonne, Kwong, Ava

“…Internationally, breast cancer is the most common female cancer, and is induced by a combination of environmental, genetic, and epigenetic risk factors…”
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Abstract 4415: Characterization of tumor-derived exosomes in BRCA -associated breast tumors by Shin, Vivian Y., Siu, Man-Ting, Cheuk, Isabella, Kwong, Ava

“…Background: BRCA-mutated tumors are usually with higher grade than sporadic tumors and the biology is poorly understood. Exosomes are small membrane-derived…”
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miR-199a-5p confers tumor-suppressive role in triple-negative breast cancer by Chen, Jiawei, Shin, Vivian Y, Siu, Man T, Ho, John C W, Cheuk, Isabella, Kwong, Ava

“…Triple-negative breast cancer (TNBC) remains a poor prognostic factor for breast cancer since no effective targeted therapy is readily available. Our previous…”
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Abstract P1-07-01: Cholinergic receptor muscarinic 3 ( CHRM3 ) contributes to breast cancer tumorigenesis through angiogenesis regulation by Chen, Jiawei, Shin, Vivian Y, Cheuk, Isabella, Siu, Jennifer, Kwong, Ava

“…Objectives: Cholinergic muscarinic receptors are widely distributed in different human organs with various biological functionals such as synaptic…”
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ITGAV targeting as a therapeutic approach for treatment of metastatic breast cancer by Cheuk, Isabella Wai-Yin, Siu, Man Ting, Ho, John Chi-Wang, Chen, Jiawei, Shin, Vivian Yvonne, Kwong, Ava

“…During tumorigenesis and metastasis, integrins regulate localization and activity of proteolytic enzymes that remodel the extracellular matrix. Previous…”
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Abstract P6-06-16: Resveratrol enhanced chemosensitivity by reversing macrophage polarization in breast cancer by Cheuk, Isabella Wai Yin, Chen, Jiawei, Siu, Man Ting, Lam, Sau Wing, Wang, Jue, Shin, Vivian Yvonne, Kwong, Ava

“…Background: Resveratrol is a naturally occurring polyphenolic compound in Polygonum cuspidatum and is well known for its antitumor effect by targeting several…”
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MicroRNA-199a-3p promotes drug sensitivity in triple negative breast cancer by down-regulation of BRCA1 by Ho, John Chi-Wang, Chen, Jiawei, Cheuk, Isabella Wai-Yin, Siu, Man-Ting, Shin, Vivian Yvonne, Kwong, Ava

“…MiR-199a-3p was previously predicted to target tumor suppressor gene , which has been linked to cancer onset and therapeutic response. In this study, the…”
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Abstract A046: miR-199a-3p induces BRCA1 dysfunction in triple-negative breast cancer by Ho, John C., Shin, Vivian Y., Chen, Jiawei, Siu, Man T., Cheuk, Isabella, Kwong, Ava

“…Background: BRCA1 mutations are highly susceptible to familial breast and ovarian cancer, as well as the more aggressive triple-negative breast cancer (TNBC)…”
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Abstract P6-08-13: Personalized and cost-effective detection of copy number variants by molecular-barcode next-generation sequencing and long-read nanopore sequencing by Kwong, Ava, Au, Chun H, Ho, Dona N, Wong, Elaine YL, Chung, Yvonne, Law, Fian BF, Ho, Cecilia YS, Chen, Jiawei, Cheuk, Isabella W, Shin, Vivian Y, Chan, Tsun L, Ngan, Hextan YS, Ma, Edmond SK

“…Background: Germline copy number variants (CNV) of hereditary breast and ovarian cancer genes are a known class of clinically significant mutations. However,…”
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Abstract P2-07-07: Prostaglandin E receptor 2 (EP2) regulates breast cancer stem-cell like property and promotes epithelial-mesenchymal transition by Shin, Vivian Y, Siu, Man T, Ho, John C, Cheuk, Isabella, Chen, Jiawei, Kwong, Ava

“…Background: Presence of cancer stem-like cells (CSCs) is the main obstacle for poor treatment response and mortality in breast cancer patients. Prostaglandin E…”
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