Search Results - "Chetwynd, A."

The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells by Johansen, Valdemar B. I., Hampson, Elizabeth, Tsonou, Elpida, Pantarelli, Chiara, Chu, Julia Y., Crossland, Laraine, Okkenhaug, Hanneke, Massey, Andrew J., Hornigold, David C., Welch, Heidi C. E., Chetwynd, Stephen A.

“…Norbin is an adaptor protein that binds numerous G protein-coupled receptors (GPCRs), is highly expressed in neurons, and is essential for a functioning…”
Get full text

Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses by Hornigold, Kirsti, Chu, Julia Y., Chetwynd, Stephen A., Machin, Polly A., Crossland, Laraine, Pantarelli, Chiara, Anderson, Karen E., Hawkins, Phillip T., Segonds-Pichon, Anne, Oxley, David, Welch, Heidi C. E.

“…Host defense against bacterial and fungal infections diminishes with age. In humans, impaired neutrophil responses are thought to contribute to this decline…”
Get full text

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis by Machin, Polly A, Johnsson, Anna-Karin E, Massey, Ellie J, Pantarelli, Chiara, Chetwynd, Stephen A, Chu, Julia Y, Okkenhaug, Hanneke, Segonds-Pichon, Anne, Walker, Simon, Malliri, Angeliki, Fukui, Yoshinori, Welch, Heidi C E

“…Rac-GTPases and their Rac-GEF activators play important roles in neutrophil-mediated host defence. These proteins control the adhesion molecules and…”
Get full text

The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses by Hornigold, Kirsti, Baker, Martin J, Machin, Polly A, Chetwynd, Stephen A, Johnsson, Anna-Karin, Pantarelli, Chiara, Islam, Priota, Stammers, Melanie, Crossland, Laraine, Oxley, David, Okkenhaug, Hanneke, Walker, Simon, Walker, Rachael, Segonds-Pichon, Anne, Fukui, Yoshinori, Malliri, Angeliki, Welch, Heidi C E

“…Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions…”
Get full text

Asymptomatic primary biliary cirrhosis: clinical features, prognosis, and symptom progression in a large population based cohort by Prince, M I, Chetwynd, A, Craig, W L, Metcalf, J V, James, O F W

“…Background: Many patients with primary biliary cirrhosis (PBC) are asymptomatic at the time of diagnosis. However, because most studies of asymptomatic PBC…”
Get full text

Second-Order Analysis of Inhomogeneous Spatial Point Processes Using Case-Control Data by Diggle, P.J, Gómez-Rubio, V, Brown, P.E, Chetwynd, A.G, Gooding, S

“…Methods for the statistical analysis of stationary spatial point process data are now well established, methods for nonstationary processes less so. One of…”
Get full text

Individual inconsistency across measures of inhibition: an investigation of the construct validity of inhibition in older adults by Shilling, V.M, Chetwynd, A, Rabbitt, P.M.A

“…Inhibition is a central construct to the frontal lobe theory of ageing, yet its construct validity remains unproven. Furthermore, age effects on measures of…”
Get full text

Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data by Cardwell, C. R., Stene, L. C., Joner, G., Davis, E. A., Cinek, O., Rosenbauer, J., Ludvigsson, J., Castell, C., Svensson, J., Goldacre, M. J., Waldhoer, T., Polanska, J., Gimeno, S. G. A., Chuang, L.-M., Parslow, R. C., Wadsworth, E. J. K., Chetwynd, A., Pozzilli, P., Brigis, G., Urbonaitė, B., Šipetić, S., Schober, E., Ionescu-Tirgoviste, C., de Beaufort, C. E., Stoyanov, D., Buschard, K., Patterson, C. C.

“…Aims/hypothesis We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes. Methods Relevant studies published before…”
Get full text

The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse neutrophils by Chetwynd, Stephen A., Ward, Richard J., Milligan, Graeme, Welch, Heidi C.E.

“…Norbin (Neurochondrin, NCDN) is a G protein–coupled receptor (GPCR) adaptor protein known for its importance in neuronal function. Norbin works by binding to…”
Get full text

Type 1 diabetes mellitus in childhood: a matched case control study in Lancashire and Cumbria, UK by Marshall, A. L., Chetwynd, A., Morris, J. A., Placzek, M., Smith, C., Olabi, A., Thistlethwaite, D.

“…Aims  The aim of the study was to identify environmental risk factors for insulin‐dependent diabetes mellitus (Type 1 DM) in childhood. Methods  A matched…”
Get full text

Second-Order Analysis of Spatial Clustering for Inhomogeneous Populations by Diggle, P. J., Chetwynd, A. G.

“…Motivated by recent interest in the possible spatial clustering of rare diseases, the paper develops an approach to the assessment of spatial clustering based…”
Get full text

Second-order analysis of space-time clustering by Diggle, P J, Chetwynd, A G, Häggkvist, R, Morris, S E

“…We consider the problem of detecting and describing space-time interaction in point process data. We extend existing second-order methods for purely spatial…”
Get more information

Effect and duration of lung volume reduction surgery: mid-term results of the Brompton trial by Lim, E, Ali, A, Cartwright, N, Sousa, I, Chetwynd, A, Polkey, M, Geddes, D, Pepper, J, Diggle, P, Goldstraw, P

“…Although many studies have reported improvement in lung function following LVRS, the magnitude of improvement and subsequent decline has not been evaluated…”
Get more information

Investigation of spatial clustering from individually matched case-control studies by Chetwynd, A G, Diggle, P J, Marshall, A, Parslow, R

“…The paper demonstrates how existing theory to assess spatial clustering based on second-moment properties of a labelled point process can be adapted to matched…”
Get full text

A mixture model for sucking patterns of breast-fed infants by Chetwynd, Amanda G., Diggle, Peter J., Drewett, Robert F., Young, Bridget

“…Previous studies of sucking patterns have mainly been on bottle‐fed babies and have assumed that the babies' sucks occur within bursts separated by gaps of…”
Get full text

Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: Follow-up for up to 28 years by Prince, Martin, Chetwynd, Amanda, Newman, Wendy, Metcalf, Jane V., James, Oliver F.W.

“…Background & Aims: Although several excellent studies have described the natural history of primary biliary cirrhosis, most were reported from tertiary…”
Get full text

The Total Chromatic Number of Graphs of High Minimum Degree by Chetwynd, A. G., Hilton, A. J. W., Cheng, Zhao

“…If G is a simple graph with minimum degree δ(G) satisfying δ(G)≥ ⅚ f(|V(G|+1) the total chromatic number conjecture holds; moreover if δ(G) ≥ ¾ |V(G| then…”
Get full text

Birth order and childhood type 1 diabetes risk: a pooled analysis of 31 observational studies by CARDWELL, Chris R, STENE, Lars C, JAROSZ-CHOBOT, Przemyslawa, GIMENO, Suely Ga, CHUANG, Lee-Ming, ROBERTS, Christine L, PARSLOW, Roger C, WADSWORTH, Emma Jk, CHETWYND, Amanda, BRIGIS, Girts, URBONAITE, Brone, SIPETIC, Sandra, JONER, Geir, SCHOBER, Edith, DEVOTI, Gabriele, IONESCU-TIRGOVISTE, Constantin, DE BEAUFORT, Carine E, STOYANOV, Denka, BUSCHARD, Karsten, RADON, Katja, GLATTHAAR, Christopher, PATTERSON, Chris C, BULSARA, Max K, CEINEK, Ondrej, ROSENBAUER, Joachim, LUDVIGSSON, Johnny, SVENSSON, Jannet, GOLDACRE, Michael J, WALDHOER, Thomas

“…The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease remains largely…”
Get full text

Supporting student learning by Anderson, J, Austin, K, Barnard, T, Chetwynd, A, Kahn, P

“…An electronic survey indicates that there is a wide variety of methods which are currently used in UK higher education institutions to support undergraduate…”
Get full text

Regular Graphs of High Degree are 1-Factorizable by Chetwynd, A. G., Hilton, A. J. W.

“…It is a well-known conjecture that if a regular graph G of order 2n has degree d(G) satisfying d(G) ≥ n, then G is the union of edge-disjoint 1-factors. It is…”
Get full text