Search Results - "Chester, Kerry"

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy by Maruani, Antoine, Smith, Mark E.B., Miranda, Enrique, Chester, Kerry A., Chudasama, Vijay, Caddick, Stephen

“…Although recent methods for the engineering of antibody–drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction,…”
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The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity by Thistlethwaite, Fiona C., Gilham, David E., Guest, Ryan D., Rothwell, Dominic G., Pillai, Manon, Burt, Deborah J., Byatte, Andrea J., Kirillova, Natalia, Valle, Juan W., Sharma, Surinder K., Chester, Kerry A., Westwood, Nigel B., Halford, Sarah E. R., Nabarro, Stephen, Wan, Susan, Austin, Eric, Hawkins, Robert E.

“…The primary aim of this clinical trial was to determine the feasibility of delivering first-generation CAR T cell therapy to patients with advanced, CEACAM5 +…”
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Stromal features are predictive of disease mortality in oral cancer patients by Marsh, Daniel, Suchak, Krishna, Moutasim, Karwan A, Vallath, Sabarinath, Hopper, Colin, Jerjes, Waseem, Upile, Tahwinder, Kalavrezos, Nicholas, Violette, Shelia M, Weinreb, Paul H, Chester, Kerry A, Chana, Jagdeep S, Marshall, John F, Hart, Ian R, Hackshaw, Allan K, Piper, Kim, Thomas, Gareth J

“…Worldwide, approximately 405 000 cases of oral cancer (OSCC) are diagnosed each year, with a rising incidence in many countries. Despite advances in surgery…”
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Tuning the Hydrolytic Stability of Next Generation Maleimide Cross-Linkers Enables Access to Albumin-Antibody Fragment Conjugates and tri-scFvs by Forte, Nafsika, Livanos, Maria, Miranda, Enrique, Morais, Maurício, Yang, Xiaoping, Rajkumar, Vineeth S, Chester, Kerry A, Chudasama, Vijay, Baker, James R

“…We describe investigations to expand the scope of next generation maleimide cross-linkers for the construction of homogeneous protein–protein conjugates…”
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Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging by Schumacher, Felix F, Nunes, João P M, Maruani, Antoine, Chudasama, Vijay, Smith, Mark E B, Chester, Kerry A, Baker, James R, Caddick, Stephen

“…The advent of Adcetris™ and Kadcyla™, two recently FDA-approved antibody-drug conjugates (ADCs), in the clinic has had a major impact on the treatment of…”
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A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy by Ferry, Gabrielle M., Agbuduwe, Charles, Forrester, Megan, Dunlop, Sophie, Chester, Kerry, Fisher, Jonathan, Anderson, John, Barisa, Marta

“…The γδT cell subset of peripheral lymphocytes exhibits potent cancer antigen recognition independent of classical peptide MHC complexes, making it an…”
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Anti-CD45 PBD-based antibody-drug conjugates are effective targeted conditioning agents for gene therapy and stem cell transplant by Yeung, Jenny, Liao, Aiyin, Shaw, Matthew, Silva, Soraia, Vetharoy, Winston, Rico, Diego Leon, Kirby, Ian, Zammarchi, Francesca, Havenith, Karin, de Haan, Lolke, van Berkel, Patrick H, Sebire, Neil, Ogunbiyi, Olumide K, Booth, Claire, Gaspar, H Bobby, Thrasher, Adrian J, Chester, Kerry A, Amrolia, Persis J

“…Stem cell gene therapy and hematopoietic stem cell transplantation (SCT) require conditioning to ablate the recipient's hematopoietic stem cells (HSCs) and…”
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Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation by Carter, Thomas J., Agliardi, Giulia, Lin, Fang‐Yu, Ellis, Matthew, Jones, Clare, Robson, Mathew, Richard‐Londt, Angela, Southern, Paul, Lythgoe, Mark, Zaw Thin, May, Ryzhov, Vyacheslav, Rosales, Rafael T. M., Gruettner, Cordula, Abdollah, Maha R. A., Pedley, R. Barbara, Pankhurst, Quentin A., Kalber, Tammy L., Brandner, Sebastian, Quezada, Sergio, Mulholland, Paul, Shevtsov, Maxim, Chester, Kerry

“…Magnetic hyperthermia (MH) harnesses the heat‐releasing properties of superparamagnetic iron oxide nanoparticles (SPIONs) and has potential to stimulate immune…”
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Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70‐Positive Tumors for Multimodal Cancer Theranostics by Shevtsov, Maxim, Stangl, Stefan, Nikolaev, Boris, Yakovleva, Ludmila, Marchenko, Yaroslav, Tagaeva, Ruslana, Sievert, Wolfgang, Pitkin, Emil, Mazur, Anton, Tolstoy, Peter, Galibin, Oleg, Ryzhov, Vyacheslav, Steiger, Katja, Smirnov, Oleg, Khachatryan, William, Chester, Kerry, Multhoff, Gabriele

“…Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as potential clinical tools for cancer theranostics. Membrane‐bound 70 kDa heat…”
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Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance by Chakravarthy, Ankur, Reddin, Ian, Henderson, Stephen, Dong, Cindy, Kirkwood, Nerissa, Jeyakumar, Maxmilan, Rodriguez, Daniela Rothschild, Martinez, Natalia Gonzalez, McDermott, Jacqueline, Su, Xiaoping, Egawa, Nagayasau, Fjeldbo, Christina S., Skingen, Vilde Eide, Lyng, Heidi, Halle, Mari Kyllesø, Krakstad, Camilla, Soleiman, Afschin, Sprung, Susanne, Lechner, Matt, Ellis, Peter J. I., Wass, Mark, Michaelis, Martin, Fiegl, Heidi, Salvesen, Helga, Thomas, Gareth J., Doorbar, John, Chester, Kerry, Feber, Andrew, Fenton, Tim R.

“…Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643…”
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Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation by Castañeda, Lourdes, Maruani, Antoine, Schumacher, Felix F, Miranda, Enrique, Chudasama, Vijay, Chester, Kerry A, Baker, James R, Smith, Mark E B, Caddick, Stephen

“…In this communication we describe a novel acid-cleavable linker strategy for antibody-drug conjugation. Functional disulfide bridging of the single interchain…”
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A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectors by Floerchinger, Alessia, Klein, Jessica E., Finkbeiner, Maximiliane S. C., Schäfer, Theresa E., Fuchs, Gwendolin, Doerner, Johannes, Zirngibl, Hubert, Ackermann, Maximilian, Kvasnicka, Hans M., Chester, Kerry A., Jäger, Dirk, Ball, Claudia R., Ungerechts, Guy, Engeland, Christine E.

“…Treatment with oncolytic measles vaccines (MV) elicits activation of immune cells, including natural killer (NK) cells. However, we found that MV-activated NK…”
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Homogeneous Bispecifics by Disulfide Bridging by Hull, Elizabeth A, Livanos, Maria, Miranda, Enrique, Smith, Mark E. B, Chester, Kerry A, Baker, James R

“…We report on a chemical platform to generate site-specific, homogeneous, antibody–antibody conjugates by targeting and bridging disulfide bonds. A bispecific…”
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scFv biofunctionalized nanoparticles to effective and safe targeting of CEA-expressing colorectal cancer cells by Silveira, Maria José, Martins, Cláudia, Cruz, Tânia, Castro, Flávia, Amorim-Costa, Ângela, Chester, Kerry, Oliveira, Maria José, Sarmento, Bruno

“…Abstract Colorectal cancer (CRC) is one of the deadliest cancers worldwide, with the 5 year survival rate in metastatic cases limited to 12%. The design of…”
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Antibody-drug conjugates - a perfect synergy by Adair, John R, Howard, Philip W, Hartley, John A, Williams, David G, Chester, Kerry A

“…There is a great unmet need for effective new treatments in cancer, which continues to be a major cause of death. Antibody-drug conjugates (ADCs) are emerging,…”
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Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds by Marculescu, Cristina, Kossen, Hanno, Morgan, Rachel E, Mayer, Patrick, Fletcher, Sally A, Tolner, Berend, Chester, Kerry A, Jones, Lyn H, Baker, James R

“…Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe…”
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Preclinical evaluation of a novel CEA‐targeting near‐infrared fluorescent tracer delineating colorectal and pancreatic tumors by Boonstra, Martin C., Tolner, Berend, Schaafsma, Boudewijn E., Boogerd, Leonora S.F., Prevoo, Hendrica A.J.M, Bhavsar, Guarav, Kuppen, Peter J.K., Sier, Cornelis F.M., Bonsing, Bert A., Frangioni, John V., van de Velde, Cornelis J.H., Chester, Kerry A., Vahrmeijer, Alexander L.

“…Surgery is the cornerstone of oncologic therapy with curative intent. However, identification of tumor cells in the resection margins is difficult, resulting…”
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Targeted photodynamic therapy with multiply‐loaded recombinant antibody fragments by Bhatti, Manpreet, Yahioglu, Gokhan, Milgrom, Lionel R., Garcia‐Maya, Mitla, Chester, Kerry A., Deonarain, Mahendra P.

“…Current photodynamic therapy (PDT) of cancer is limited by inefficiencies involved in specifically targeting photosensitizers to tumors. Although antibodies…”
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Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’ by Schumacher, Felix F., Sanchania, Vishal A., Tolner, Berend, Wright, Zoë V. F., Ryan, Chris P., Smith, Mark E. B., Ward, John M., Caddick, Stephen, Kay, Christopher W. M., Aeppli, Gabriel, Chester, Kerry A., Baker, James R.

“…A major obstacle to the efficient production of antibody conjugates for therapy and diagnosis is the non-ideal performance of commonly used chemical methods…”
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A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers by Birley, Kathleen, Leboreiro-Babe, Clara, Rota, Enrique Miranda, Buschhaus, Magdalena, Gavriil, Artemis, Vitali, Alice, Alonso-Ferrero, Maria, Hopwood, Lee, Parienti, Lara, Ferry, Gabrielle, Flutter, Barry, Himoudi, Nourredine, Chester, Kerry, Anderson, John

“…B7-H3 (CD276) has emerged as a target for cancer immunotherapy by virtue of consistent expression in many malignancies, relative absence from healthy tissues,…”
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