Search Results - "Chesire, Amy"

Palliative Care in Huntington Disease: Personal Reflections and a Review of the Literature by Tarolli, Christopher G, Chesire, Amy M, Biglan, Kevin M

“…BACKGROUNDHuntington disease is a fatal, autosomal dominant, neurodegenerative disorder manifest by the triad of a movement disorder, behavioral disturbances,…”
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Palliative Care in Huntington Disease: Personal Reflections and a Review of the Literature by Tarolli, Christopher G, Chesire, Amy M, Biglan, Kevin M

“…Huntington disease is a fatal, autosomal dominant, neurodegenerative disorder manifest by the triad of a movement disorder, behavioral disturbances, and…”
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Reply: An exploration of the burden experienced by spousal caregivers of individuals with Parkinson's disease by Deuel, Lisa M., Chesire, Amy M., Eason, Sheelah, Como, Peter G., Biglan, Kevin M.

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Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington's disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial by Furr Stimming, Erin, Claassen, Daniel O, Kayson, Elise, Goldstein, Jody, Mehanna, Raja, Zhang, Hui, Liang, Grace S, Haubenberger, Dietrich, Adams, Jamie, Beck, Christopher, Chen, Cheryl, Nance, Martha, Testa, Claudia, Huffman, Patricia, Chesire, Amy, Marshall, Frederick, Dayalu, Praveen, Stovall, Angela, Hall, Deborah, Hawkins, Jacob, Ginsburg, Letty, Moore, Henry, Mestre, Tiago, Thompson, Tanya, Connors, Natalie, Rosas, H. Diana, Daley, Allison, Kostyk, Sandra K., Mitchell, Casey, Hellman, Amy, Houston, Sheryl, Buchanan, Danielle, McDonell, Katherine, Factor, Stewart A., Sperin, Elaine, Hurt, Andrea, Wojcieszek, Joanne, Adurogbangba, Mike, Raymond, Lynn A., Corey-Bloom, Jody, Snell, Chase, Blair, Courtney, Sung, Victor, Antonioli, Sophia, Fung, Jacqueline, Laganiere, Simon, Sierra, Luis, Mallonee, William M., Suter, Greg, Bega, Danny, Brown, Zsa Zsa, Elmer, Lawrence, Vollmar, Nancy, del Castillo, Debra, Lin, Yi-Han, Andrzejewski, Kelly, Weigel, Patricia, Hawkins, Trevor, Kirby, Kendra, Retzik-Stahr, Cimmaron, Seeberger, Lauren, Dhall, Rohit, Rassmann, Anja, Luxmore, McKenzie, Scott, Burton, Bulica, Bisena, Boyd, James, Chan, Katherine, McFarland, Nikolaus, Rizer, Kyle, Conlon, Patricia, Suski, Valerie, Rodriguez-Porcel, Federico, Wilson, Sandra, Farrell, Christine, Hunter, David, Houghton, David, Seoane, Sarah, Gibbons, Clare, Rizek, Philippe, Kuprewicz, Robin, Lo, Steven, Cuturic, Miroslav, Segro, Vicki, Greenly, Kate, Revilla, Fredy, Urrea-Mendoza, Enrique, Black, Kevin J., Davis, Thomas, Stover, Natividad, Duker, Andrew, Van Gerpen, Jay, Hedera, Peter, Ondo, William, Anderson, Karen, Bradley, Stephen, Cheung, Ken, Frank, Samuel

“…Valbenazine is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor approved for treatment of tardive dyskinesia. To address the ongoing need…”
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Clinical and Biomarker Changes in Premanifest Huntington Disease Show Trial Feasibility: A Decade of the PREDICT-HD Study by Paulsen, Jane S, Long, Jeffrey D, Johnson, Hans J, Aylward, Elizabeth H, Ross, Christopher A, Williams, Janet K, Nance, Martha A, Erwin, Cheryl J, Westervelt, Holly J, Harrington, Deborah L, Bockholt, H Jeremy, Zhang, Ying, McCusker, Elizabeth A, Chiu, Edmond M, Panegyres, Peter K

“…There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention…”
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Prefrontal cortex white matter tracts in prodromal Huntington disease by Matsui, Joy T., Vaidya, Jatin G., Wassermann, Demian, Kim, Regina Eunyoung, Magnotta, Vincent A., Johnson, Hans J., Paulsen, Jane S.

“…Huntington disease (HD) is most widely known for its selective degeneration of striatal neurons but there is also growing evidence for white matter (WM)…”
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Cognitive domains that predict time to diagnosis in prodromal Huntington disease by Harrington, Deborah Lynn, Smith, Megan M, Zhang, Ying, Carlozzi, Noelle E, Paulsen, Jane S

“…BackgroundProdromal Huntington's disease (prHD) is associated with a myriad of cognitive changes but the domains that best predict time to clinical diagnosis…”
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Multivariate prediction of motor diagnosis in Huntington's disease: 12 years of PREDICT-HD by Long, Jeffrey D., Paulsen, Jane S.

“…Background It is well known in Huntington's disease that cytosine‐adenine‐guanine expansion and age at study entry are predictive of the timing of motor…”
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Tracking motor impairments in the progression of Huntington's disease by Long, Jeffery D., Paulsen, Jane S., Marder, Karen, Zhang, Ying, Kim, Ji-In, Mills, James A.

“…ABSTRACT The Unified Huntington's Disease Rating Scale is used to characterize motor impairments and establish motor diagnosis. Little is known about the…”
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8OHdG as a marker for Huntington disease progression by Long, Jeffrey D, Matson, Wayne R, Juhl, Andrew R, Leavitt, Blair R, Paulsen, Jane S

“…Abstract Leukocyte 8-hydroxydeoxyguanosine (8OHdG) is an indicator of oxidative stress, impaired metabolism, and mitochondrial dysfunction, features that have…”
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Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis by Soneson, Charlotte, Fontes, Magnus, Zhou, Yongxia, Denisov, Vladimir, Paulsen, Jane S, Kirik, Deniz, Petersén, Åsa

“…Abstract Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of…”
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Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington's Disease Patients-A Randomized Phase 2 Clinical Trial by Brownstein, Michael J, Simon, Neal G, Long, Jeffrey D, Yankey, Jon, Maibach, Hilda T, Cudkowicz, Merit, Coffey, Christopher, Conwit, Robin A, Lungu, Codrin, Anderson, Karen E, Hersch, Steven M, Ecklund, Dixie J, Damiano, Eve M, Itzkowitz, Debra E, Lu, Shifang, Chase, Marianne K, Shefner, Jeremy M, McGarry, Andrew, Thornell, Brenda, Gladden, Catherine, Costigan, Michele, O'Suilleabhain, Padraig, Marshall, Frederick J, Chesire, Amy M, Deritis, Paul, Adams, Jamie L, Hedera, Peter, Lowen, Kelly, Rosas, H Diana, Hiller, Amie L, Quinn, Joseph, Keith, Kellie, Duker, Andrew P, Gruenwald, Christina, Molloy, Angela, Jacob, Cara, Factor, Stewart, Sperin, Elaine, Bega, Danny, Brown, Zsazsa R, Seeberger, Lauren C, Sung, Victor W, Benge, Melanie, Kostyk, Sandra K, Daley, Allison M, Perlman, Susan, Suski, Valerie, Conlon, Patricia, Barrett, Matthew J, Lowenhaupt, Stephanie, Quigg, Mark, Perlmutter, Joel S, Wright, Brenton A, Most, Elaine, Schwartz, Guy J, Lamb, Jessica, Chuang, Rosalind S, Singer, Carlos, Marder, Karen, Moran, Joyce A, Singleton, John R, Zorn, Meghan, Wall, Paola V, Dubinsky, Richard M, Gray, Carolyn, Drazinic, Carolyn

“…SRX246 is a vasopressin (AVP) 1a receptor antagonist that crosses the blood-brain barrier. It reduced impulsive aggression, fear, depression and anxiety in…”
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Multivariate Clustering of Progression Profiles Reveals Different Depression Patterns in Prodromal Huntington Disease by Kim, Ji-in, Long, Jeffrey D, Mills, James A, McCusker, Elizabeth, Paulsen, Jane S

“…Objective: Although Huntington disease (HD) is caused by an autosomal dominant mutation, its phenotypic presentation differs widely. Variability in clinical…”
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Perception, experience, and response to genetic discrimination in Huntington disease: The international RESPOND-HD study by Erwin, Cheryl, Williams, Janet K., Juhl, Andrew R., Mengeling, Michelle, Mills, James A., Bombard, Yvonne, Hayden, Michael R., Quaid, Kimberly, Shoulson, Ira, Taylor, Sandra, Paulsen, Jane S.

“…Genetic discrimination—defined as the denial of rights, privileges, or opportunities or other adverse treatment based solely on genetic information (including…”
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Intra-individual Variability in Prodromal Huntington Disease and Its Relationship to Genetic Burden by Musso, Mandi, Westervelt, Holly James, Long, Jeffrey D, Morgan, Erin, Woods, Steven Paul, Smith, Megan M, Lu, Wenjing, Paulsen, Jane S

“…The current study sought to examine the utility of intra-individual variability (IIV) in distinguishing participants with prodromal Huntington disease (HD)…”
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In their own words: Reports of stigma and genetic discrimination by people at risk for Huntington disease in the International RESPOND-HD study by Williams, Janet K., Erwin, Cheryl, Juhl, Andrew R., Mengeling, Michelle, Bombard, Yvonne, Hayden, Michael R., Quaid, Kimberly, Shoulson, Ira, Taylor, Sandra, Paulsen, Jane S.

“…Genetic discrimination may be experienced in the day‐to‐day lives of people at risk for Huntington disease (HD), encompassing occurrences in the workplace,…”
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The impact of oculomotor functioning on neuropsychological performance in Huntington disease by Carvalho, Janessa O., Long, Jeffrey D., Westervelt, Holly J., Smith, Megan M., Bruce, Jared M., Kim, Ji-In, Mills, James A., Paulsen, Jane S., the PREDICT-HD Investigators and Coordinators of the Huntington Study Group

“…Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While…”
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Regional atrophy associated with cognitive and motor function in prodromal Huntington disease by Aylward, Elizabeth H, Harrington, Deborah L, Mills, James A, Nopoulos, Peggy C, Ross, Christopher A, Long, Jeffrey D, Liu, Dawei, Westervelt, Holly K, Paulsen, Jane S

“…Neuroimaging studies suggest that volumetric MRI measures of specific brain structures may serve as excellent biomarkers in future clinical trials of…”
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Development of the Huntington Disease Work Function Scale by Brossman, Bradley, Williams, Janet K., Downing, Nancy, Mills, James A., Paulsen, Jane S.

“…Objective: A work function measure specific for persons with prodromal Huntington disease (HD) was created to assist with workplace accommodations. Methods: A…”
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High and Low Levels of an NTRK2-Driven Genetic Profile Affect Motor- and Cognition-Associated Frontal Gray Matter in Prodromal Huntington's Disease by Ciarochi, Jennifer A, Liu, Jingyu, Calhoun, Vince, Johnson, Hans, Misiura, Maria, Bockholt, H Jeremy, Espinoza, Flor A, Caprihan, Arvind, Plis, Sergey, Turner, Jessica A, Paulsen, Jane S

“…This study assessed how (brain-derived neurotrophic factor) and other genes involved in its signaling influence brain structure and clinical functioning in…”
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