Search Results - "Cheruiyot, Samwel K"

Fluorescent 2-Aminopyridine Nucleobases for Triplex-Forming Peptide Nucleic Acids by Cheruiyot, Samwel K., Rozners, Eriks

“…Development of new fluorescent peptide nucleic acids (PNAs) is important for fundamental research and practical applications. The goal of this study was the…”
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Using triple-helix-forming Peptide nucleic acids for sequence-selective recognition of double-stranded RNA by Hnedzko, Dziyana, Cheruiyot, Samwel K, Rozners, Eriks

“…Non-coding RNAs play important roles in regulation of gene expression. Specific recognition and inhibition of these biologically important RNAs that form…”
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Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs by Mutisya, Daniel, Hardcastle, Travis, Cheruiyot, Samwel K, Pallan, Pradeep S, Kennedy, Scott D, Egli, Martin, Kelley, Melissa L, Smith, Anja van Brabant, Rozners, Eriks

“…While the use of RNA interference (RNAi) in molecular biology and functional genomics is a well-established technology, in vivo applications of synthetic short…”
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A Single Amide Linkage in the Passenger Strand Suppresses Its Activity and Enhances Guide Strand Targeting of siRNAs by Hardcastle, Travis, Novosjolova, Irina, Kotikam, Venubabu, Cheruiyot, Samwel K, Mutisya, Daniel, Kennedy, Scott D, Egli, Martin, Kelley, Melissa L, Smith, Anja van Brabant, Rozners, Eriks

“…Potential in vivo applications of RNA interference (RNAi) require suppression of various off-target activities. Herein, we report that replacement of a single…”
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