Search Results - "Cheronis, John C."

Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase by Ohmoto, Kazuyuki, Yamamoto, Tetsuya, Horiuchi, Toshihide, Imanishi, Hirotoshi, Odagaki, Yoshihiko, Kawabata, Kazuhito, Sekioka, Tomohiko, Hirota, Yasushi, Matsuoka, Shozo, Nakai, Hisao, Toda, Masaaki, Cheronis, John C, Spruce, Lyle W, Gyorkos, Albert, Wieczorek, Maciej

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A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers by Cheronis, John C, Whalley, Eric T, Nguyen, Khe T, Eubanks, Shad R, Allen, Lisa G, Duggan, Matthew J, Loy, Sharon D, Bonham, Kathryn A, Blodgett, James K

“…A systematic study on the dimerization of the bradykinin (BK) antagonist D-Arg0-Arg1-Pro2-Hyp3-Gly4-Phe5-Ser6-D-Phe 7-Leu8-Arg9 has been performed. The first…”
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Development of Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase by Ohmoto, Kazuyuki, Yamamoto, Tetsuya, Okuma, Motohiro, Horiuchi, Toshihide, Imanishi, Hirotoshi, Odagaki, Yoshihiko, Kawabata, Kazuhito, Sekioka, Tomohiko, Hirota, Yasushi, Matsuoka, Shozo, Nakai, Hisao, Toda, Masaaki, Cheronis, John C, Spruce, Lyle W, Gyorkos, Albert, Wieczorek, Maciej

“…5-Amino-2-phenylpyrimidin-6-ones, some of their desamino derivatives, and miscellaneous derivatives were synthesized and biologically evaluated on both in…”
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High-precision analysis of gene expression in whole blood: assessment of patient status and response to therapy by Cheronis, John C

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High-precision gene expression analysis of immunosuppressive agents in human whole blood by Tryon, Victor V., Cheronis, John C., Trollinger, David B., Bankaitis-Davis, Danute, Storm, Kathleen, Zuzack, John S., Zhan, Min, Macejak, Dennis G., Bevilacqua, Michael P.

“…Analysis of gene expression is emerging as a valuable tool in drug discovery. Using a gene expression system involving high‐precision quantitative PCR, two…”
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Design, synthesis, and in vitro activity of bis(succinimido)hexane peptide heterodimers with combined B1 and B2 antagonist activity by Cheronis, John C, Whalley, Eric T, Allen, Lisa G, Loy, Sharon D, Elder, Megan W, Duggan, Matthew J, Gross, Kelly L, Blodgett, James K

“…We have developed a series of peptide heterodimers based on the B2 antagonist D-Arg0-[Hyp3,D-Phe7,Leu8]-BK (1) and the B1 antagonist Lys0-[Leu8,des-Arg9]-BK…”
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Effect of combined B1 and B2 kinin receptor blockade in porcine endotoxin shock by Siebeck, Matthias, Spannagl, Erwin, Schorr, Markus, Stumpf, Bernhard, Fritz, Hans, Whalley, Eric T., Cheronis, John C.

“…In order to investigate the contribution of kinin receptor antagonism in the treatment of LPS-induced shock we conducted a randomized study with anaesthetized…”
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Association of psychiatric manifestations with antibodies to ribosomal P proteins in systemic lupus erythematosus by Schneebaum, A B, Singleton, J D, West, S G, Blodgett, J K, Allen, L G, Cheronis, J C, Kotzin, B L

“…The goal of this study was to determine whether elevated serum levels of antibodies to ribosomal P proteins (anti-P antibodies) are associated with…”
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Introduction by C. Cheronis, John

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Biochemical Characterization of α-Ketooxadiazole Inhibitors of Elastases by Wieczorek, Maciej, Gyorkos, Albert, Spruce, Lyle W., Ettinger, Anna, Ross, Sherman E., Kroona, Heather S., Burgos-Lepley, Carmen E., Bratton, Larry D., Drennan, Tyler S., Garnert, Douglas L., Von Burg, Gregory, Pilkington, Carolyn G., Cheronis, John C.

“…A series of α-ketooxadiazole compounds was prepared and evaluated in vitro as potential inhibitors of human neutrophil elastase (HNE), proteinase-3 (PR-3), and…”
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Purification and characterization of a novel zinc-proteinase from cultures of Aeromonas hydrophila by LOEWY, A. G, SANTER, U. V, WIECZOREK, M, BLODGETT, J. K, JONES, S. W, CHERONIS, J. C

“…While searching for an enzyme capable of breaking epsilon-(gamma-Glu)-Lys isopeptide bonds cross-linking protein chains, we purified a metallo-proteinase which…”
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KININ '95: International Symposium on Bradykinin and Related Kinins by STEWART, John M, WHALLEY, Eric T, CHERONIS, John C

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KININ'95: International Symposium on Bradykinin and Related Kinins by STEWART, John M, WHALLEY, Eric T, CHERONIS, John C

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B1 kinin receptor activity in pigs is associated with pre-existing infection by Siebeck, Matthias, Schorr, Markus, Spannagl, Erwin, Lehner, Markus, Fritz, Hans, Cheronis, John C., Whalley, Eric T.

“…Bradykinin (BK) and related kinins are potent inflammatory mediators produced during acute and chronic inflammation. The effects of these kinins are mediated…”
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Kinin antagonists by Cheronis, J C, Whalley, E T

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Endothelial cell associated anti-elastolytic activity by Hanley, M E, Terada, L S, Cheronis, J C, Repine, J E

“…Addition of cultured and then carefully-washed bovine pulmonary artery endothelial cells (EC) decreased (p < 0.05) human neutrophil elastase activity (HNE) in…”
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Endogenous B1 receptor mediated hypotension produced by contact system activation in the presence of endotoxemia by Schmid, Adrian, Eich-Rathfelder, Sabine, Whalley, Eric T., Cheronis, John C., Scheuber, Heinz-Peter, Fritz, Hans, Siebeck, Matthias

“…Previous studies have shown that an intravenous infusion of dextran sulfate (DXS) causes arterial hypotension via release of bradykinin (BK) and stimulation of…”
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Kinin '95 Denver 10–15 September 1995 by Stewart, John M., Whalley, Eric T., Cheronis, John C.

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Pharmacological analysis of the functional ontogeny of the nigrostriatal dopaminergic neurons by Cheronis, J C, Erinoff, L, Heller, A, Hoffmann, P C

“…Functional development of the dopaminergic nigrostriatal projection was studied by determining the age at which the biochemical responses of these neurons to…”
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Pulmonary oxygen toxicity and ischemia-reperfusion injury. A mechanism in common involving xanthine oxidase and neutrophils by Repine, J E, Cheronis, J C, Rodell, T C, Linas, S L, Patt, A

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