Search Results - "Chernyavsky, Alexander I."

Endogenous Galectin-3 Is Localized in Membrane Lipid Rafts and Regulates Migration of Dendritic Cells by Hsu, Daniel K., Chernyavsky, Alexander I., Chen, Huan-Yuan, Yu, Lan, Grando, Sergei A., Liu, Fu-Tong

“…This study reveals a function of endogenous galectin-3, an animal lectin recognizing β-galactosides, in regulating dendritic cell motility both in vitro and in…”
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Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis by Grando, Sergei A., Bystryn, Jean-Claude, Chernyavsky, Alexander I., Frušić-Zlotkin, Marina, Gniadecki, Robert, Lotti, Roberta, Milner, Yoram, Pittelkow, Mark R., Pincelli, Carlo

“…:  Understanding the acantholytic pathways leading to blistering in pemphigus vulgaris (PV) is a key to development of novel treatments. A novel paradigm of…”
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Biological Effects of SLURP-1 on Human Keratinocytes by Arredondo, Juan, Chernyavsky, Alexander I., Webber, Robert J., Grando, Sergei A.

“…A novel paradigm of keratinocyte (KC) regulation via nicotinic acetylcholine receptors (nAChR) has been discovered in studies of SLURP (secreted mammalian…”
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SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium by Arredondo, Juan, Chernyavsky, Alexander I., Jolkovsky, David L., Webber, Robert J., Grando, Sergei A.

“…The biologic role of novel cholinergic toxin‐like signaling peptides termed SLURP (secreted mammalian Ly‐6/uPAR‐related protein) in the mucocutaneous…”
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SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes by Arredondo, Juan, Chernyavsky, Alexander I., Grando, Sergei A.

“…The secreted mammalian Ly-6/urokinase plasminogen activator receptor-related proteins (SLURP)-1 and -2 are produced by keratinocytes comprising the…”
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Novel cholinergic peptides SLURP-1 and -2 regulate epithelialization of cutaneous and oral wounds by Chernyavsky, Alexander I., Kalantari-Dehaghi, Mina, Phillips, Courtney, Marchenko, Steve, Grando, Sergei A.

“…It is well established that auto/paracrine acetylcholine (ACh) is essential for wound epithelialization, and that the mechanisms include regulation of…”
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The Ras/Raf-1/MEK1/ERK Signaling Pathway Coupled to Integrin Expression Mediates Cholinergic Regulation of Keratinocyte Directional Migration by Chernyavsky, Alexander I., Arredondo, Juan, Karlsson, Evert, Wessler, Ignaz, Grando, Sergei A.

“…The physiologic mechanisms that determine directionality of lateral migration are a subject of intense research. Galvanotropism in a direct current (DC)…”
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Pemphigus Vulgaris IgG and Methylprednisolone Exhibit Reciprocal Effects on Keratinocytes by Nguyen, Vu Thuong, Arredondo, Juan, Chernyavsky, Alexander I., Kitajima, Yasuo, Pittelkow, Mark, Grando, Sergei A.

“…Pemphigus vulgaris (PV) is a life-threatening autoimmune disease of skin adhesion associated with IgG autoantibodies against keratinocytes (KC). Treatment of…”
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Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis by Galitovskiy, Valentin, Qian, Jing, Chernyavsky, Alexander I, Marchenko, Steve, Gindi, Vivian, Edwards, Robert A, Grando, Sergei A

“…Ulcerative colitis (UC) and Crohn's disease (CD) are two forms of chronic inflammatory bowel disease. CD4 T cells play a central role in the pathogenesis of…”
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Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes by Nguyen, Vu Thuong, Chernyavsky, Alexander I, Arredondo, Juan, Bercovich, Dani, Orr-Urtreger, Avi, Vetter, Douglas E, Wess, Jürgen, Beaudet, Arthur L, Kitajima, Yasuo, Grando, Sergei A

“…The biological mechanisms involved in initiating, coordinating, and ultimately terminating cell—cell adhesion in the stratified epithelium are not well…”
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Cytokine-Induced Alterations of alpha 7 Nicotinic Receptor in Colonic CD4 T Cells Mediate Dichotomous Response to Nicotine in Murine Models of Th1/Th17- versus Th2-Mediated Colitis by Galitovskiy, Valentin, Qian, Jing, Chernyavsky, Alexander I, Marchenko, Steve, Gindi, Vivian, Edwards, Robert A, Grando, Sergei A

“…Ulcerative colitis (UC) and Crohn's disease (CD) are two forms of chronic inflammatory bowel disease. CD4 T cells play a central role in the pathogenesis of…”
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Antimitochondrial Autoantibodies in Pemphigus Vulgaris: A MISSING LINK IN DISEASE PATHOPHYSIOLOGY by Marchenko, Steve, Chernyavsky, Alexander I, Arredondo, Juan, Gindi, Vivian, Grando, Sergei A

“…A loss of epidermal cohesion in pemphigus vulgaris (PV) results from autoantibody action on keratinocytes (KCs) activating the signaling kinases and…”
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A Receptor-Mediated Mechanism of Nicotine Toxicity in Oral Keratinocytes by Arredondo, Juan, Nguyen, Vu Thuong, Chernyavsky, Alexander I, Jolkovsky, David L, Pinkerton, Kent E, Grando, Sergei A

“…Smoking and smokeless tobacco cause morbidity that originates from the epithelium lining of the skin and upper digestive tract. Oral keratinocytes (OKC)…”
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Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of α7 nicotinic receptor in oral keratinocytes by Arredondo, Juan, Chernyavsky, Alexander I, Jolkovsky, David L, Pinkerton, Kent E, Grando, Sergei A

“…The use of tobacco products is associated with an increased incidence of periodontal disease, poor response to periodontal therapy, and a high risk for…”
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Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression by Chernyavsky, Alexander I., Galitovskiy, Valentin, Grando, Sergei A.

“…Corneal epithelial erosion is one of the most common problems in clinical ophthalmology. Despite significant progress in understanding how the cornea heals,…”
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Functional role of α7 nicotinic receptor in physiological control of cutaneous homeostasis by Arredondo, Juan, Nguyen, Vu Thuong, Chernyavsky, Alexander I, Bercovich, Dani, Orr-Urtreger, Avi, Vetter, Douglas E, Grando, Sergei A

“…Non-neuronal nicotinic acetylcholine receptors (nAChRs) are abundantly expressed in skin and their function remains to be elucidated. Herein, we report that…”
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Keratinocyte acetylcholine receptors regulate cell adhesion by Nguyen, Vu Thuong, Arredondo, Juan, Chernyavsky, Alexander I, Kitajima, Yasuo, Grando, Sergei A

“…We investigated the mechanism mediating cholinergic control of cell-to-cell adhesion of human epidermal keratinocytes (KC) by non-neuronal acetylcholine…”
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Auto/paracrine control of inflammatory cytokines by acetylcholine in macrophage-like U937 cells through nicotinic receptors by Chernyavsky, Alexander I., Arredondo, Juan, Skok, Maryna, Grando, Sergei A.

“…Although acetylcholine (ACh ) is well known for its neurotransmitter function, recent studies have indicated that it also functions as an immune cytokine that…”
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Receptor-mediated tobacco toxicity: acceleration of sequential expression of α5 and α7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke by Arredondo, Juan, Chernyavsky, Alexander I, Jolkovsky, David L, Pinkerton, Kent E, Grando, Sergei A

“…Tobacco products and nicotine alter the cell cycle and lead to squamatization of oral keratinocytes (KCs) and squamous cell carcinoma. Activation of nicotinic…”
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Novel Mechanisms of Target Cell Death and Survival and of Therapeutic Action of IVIg in Pemphigus by Arredondo, Juan, Chernyavsky, Alexander I., Karaouni, Ali, Grando, Sergei A.

“…Pemphigus vulgaris (PV) is a potentially lethal mucocutaneous blistering disease characterized by cell-cell detachment within the stratified epithelium…”
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