Search Results - "Cherny, Stacey S"

Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets by Li, Miao-Xin, Yeung, Juilian M. Y., Cherny, Stacey S., Sham, Pak C.

“…Current genome-wide association studies (GWAS) use commercial genotyping microarrays that can assay over a million single nucleotide polymorphisms (SNPs). The…”
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Utility of the trnH-psbA intergenic spacer region and its combinations as plant DNA barcodes: a meta-analysis by Pang, Xiaohui, Liu, Chang, Shi, Linchun, Liu, Rui, Liang, Dong, Li, Huan, Cherny, Stacey S, Chen, Shilin

“…The trnH-psbA intergenic spacer region has been used in many DNA barcoding studies. However, a comprehensive evaluation with rigorous sequence preprocessing…”
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Diabetes Prevalence and Therapeutic Target Achievement in the United States, 1999 to 2006 by Cheung, Bernard M.Y., PhD, FRCP, Lond, FRCP Edin, FCP, Ong, Kwok Leung, MPhil, Cherny, Stacey S., PhD, Sham, Pak-Chung, MRPsych, PhD, Tso, Annette W.K., MRCP(UK), Lam, Karen S.L., MD, FRCP, FRACP

“…Abstract Objective Changes in the prevalence, treatment, and management of diabetes in the United States from 1999 to 2006 were studied using data from the…”
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Relationships between Circulating Biomarkers and Body Composition Parameters in Patients with Metabolic Syndrome: A Community-Based Study by Tarabeih, Nader, Kalinkovich, Alexander, Ashkenazi, Shai, Cherny, Stacey S, Shalata, Adel, Livshits, Gregory

“…Metabolic syndrome (MetS) is a complex disease involving multiple physiological, biochemical, and metabolic abnormalities. The search for reliable biomarkers…”
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Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases by So, Hon-Cheong, Gui, Allen H.S., Cherny, Stacey S., Sham, Pak C.

“…Recently, an increasing number of susceptibility variants have been identified for complex diseases. At the same time, the concern of “missing heritability”…”
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Glycoprotein Acetyls Is a Novel Biomarker Predicting Cardiovascular Complications in Rheumatoid Arthritis by Kasher, Melody, Freidin, Maxim B, Williams, Frances M K, Cherny, Stacey S, Ashkenazi, Shai, Livshits, Gregory

“…The relationship between rheumatoid arthritis (RA) and early onset atherosclerosis is well depicted, each with an important inflammatory component…”
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Bayesian network modeling of patterns of antibiotic cross-resistance by bacterial sample source by Cherny, Stacey S., Chowers, Michal, Obolski, Uri

“…Background Antimicrobial resistance is a major healthcare burden, aggravated when it extends to multiple drugs. While cross-resistance is well-studied…”
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Actionable secondary findings from whole-genome sequencing of 954 East Asians by Tang, Clara Sze-man, Dattani, Saloni, So, Man-ting, Cherny, Stacey S., Tam, Paul K. H., Sham, Pak C., Garcia-Barcelo, Maria-Mercè

“…Recently, the American College of Medical Genetics (ACMG) recommended the return of actionable secondary findings detected from clinical sequencing. The…”
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Deviation from baseline mutation burden provides powerful and robust rare-variants association test for complex diseases by Jiang, Lin, Jiang, Hui, Dai, Sheng, Chen, Ying, Song, Youqiang, Tang, Clara Sze-Man, Pang, Shirley Yin-Yu, Ho, Shu-Leong, Wang, Binbin, Garcia-Barcelo, Maria-Mercedes, Tam, Paul Kwong-Hang, Cherny, Stacey S, Li, Mulin Jun, Sham, Pak Chung, Li, Miaoxin

“…Abstract Identifying rare variants that contribute to complex diseases is challenging because of the low statistical power in current tests comparing cases…”
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Merlin-rapid analysis of dense genetic maps using sparse gene flow trees by Abecasis, Gonçalo R, Cherny, Stacey S, Cookson, William O, Cardon, Lon R

“…Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP) maps will produce data sets that exceed the limitations of current…”
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Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study by Trotta, Antonella, Iyegbe, Conrad, Di Forti, Marta, Sham, Pak C, Campbell, Desmond D, Cherny, Stacey S, Mondelli, Valeria, Aitchison, Katherine J, Murray, Robin M, Vassos, Evangelos, Fisher, Helen L

“…A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to number or severity of exposures. However, it is…”
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The analysis of causal relationships between blood lipid levels and BMD by Cherny, Stacey S, Freidin, Maxim B, Williams, Frances M K, Livshits, Gregory

“…Bone mineral density (BMD) and lipid levels are two of the most extensively studied risk factors for common diseases of aging, such as cardiovascular disease…”
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Analysis of the Associations of Measurements of Body Composition and Inflammatory Factors with Cardiovascular Disease and Its Comorbidities in a Community-Based Study by Tarabeih, Nader, Kalinkovich, Alexander, Ashkenazi, Shai, Cherny, Stacey S, Shalata, Adel, Livshits, Gregory

“…The associations of cardiovascular disease (CVD) with comorbidities and biochemical and body composition measurements are repeatedly described but have not…”
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Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening by So, Hon-Cheong, Kwan, Johnny S.H., Cherny, Stacey S., Sham, Pak C.

“…Risk prediction based on genomic profiles has raised a lot of attention recently. However, family history is usually ignored in genetic risk prediction. In…”
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Contribution of GABRG2 Polymorphisms to Risk of Epilepsy and Febrile Seizure: a Multicenter Cohort Study and Meta-analysis by Haerian, Batoul Sadat, Baum, Larry, Kwan, Patrick, Cherny, Stacey S., Shin, Jae-Gook, Kim, Sung Eun, Han, Bok-Ghee, Tan, Hui Jan, Raymond, Azman Ali, Tan, Chong Tin, Mohamed, Zahurin

“…Gamma-aminobutyric acid receptor (GABA-A) is the most common receptor of fast synaptic inhibition in the human brain. Gamma protein encoded by the GABRG2 gene…”
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Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease by Luzón-Toro, Berta, Gui, Hongsheng, Ruiz-Ferrer, Macarena, Sze-Man Tang, Clara, Fernández, Raquel M., Sham, Pak-Chung, Torroglosa, Ana, Kwong-Hang Tam, Paul, Espino-Paisán, Laura, Cherny, Stacey S., Bleda, Marta, Enguix-Riego, María del Valle, Dopazo, Joaquín, Antiñolo, Guillermo, García-Barceló, María-Mercé, Borrego, Salud

“…Hirschsprung disease (HSCR; OMIM 142623) is a developmental disorder characterized by aganglionosis along variable lengths of the distal gastrointestinal…”
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GRR: graphical representation of relationship errors by Abecasis, Gonçalo R., Cherny, Stacey S., Cookson, W. O. C., Cardon, Lon R.

“…A graphical tool for verifying assumed relationships between individuals in genetic studies is described. GRR can detect many common errors using genotypes…”
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Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese by Ong, Kwok Leung, Li, Mingfang, Tso, Annette W K, Xu, Aimin, Cherny, Stacey S, Sham, Pak Chung, Tse, Hung Fat, Lam, Tai Hing, Cheung, Bernard M Y, Lam, Karen S L

“…ObjectiveLow plasma adiponectin level can predict the development of hypertension after 5 years in our population. We therefore investigated whether…”
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Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's Disease dataset by Gui, Hongsheng, Li, Miaoxin, Sham, Pak C, Cherny, Stacey S

“…Though rooted in genomic expression studies, pathway analysis for genome-wide association studies (GWAS) has gained increasing popularity, since it has the…”
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A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits by Guo, Youling, Tomlinson, Brian, Chu, Tanya, Fang, Yu Jing, Gui, Hongsheng, Tang, Clara S, Yip, Benjamin H, Cherny, Stacey S, Hur, Yoon-Mi, Sham, Pak Chung, Lam, Tai Hing, Thomas, Neil G

“…Hypertension is caused by the interaction of environmental and genetic factors. The condition which is very common, with about 18% of the adult Hong Kong…”
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