Search Results - "Cherny, SS"

Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits by PURCELL, S, CHERNY, S. S, SHAM, P. C

“…A website for performing power calculations for the design of linkage and association genetic mapping studies of complex traits. The package is made available…”
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Deciphering the Causal Relationships Between Low Back Pain Complications, Metabolic Factors, and Comorbidities by Tarabeih, Nader, Kalinkovich, Alexander, Shalata, Adel, Cherny, Stacey S, Livshits, Gregory

“…Low back pain (LBP) is one of the major disabling health conditions in aging societies presenting significant cost burdens to health and social care systems…”
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Merlin-rapid analysis of dense genetic maps using sparse gene flow trees by Abecasis, Gonçalo R, Cherny, Stacey S, Cookson, William O, Cardon, Lon R

“…Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP) maps will produce data sets that exceed the limitations of current…”
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GRR: graphical representation of relationship errors by Abecasis, Gonçalo R., Cherny, Stacey S., Cookson, W. O. C., Cardon, Lon R.

“…A graphical tool for verifying assumed relationships between individuals in genetic studies is described. GRR can detect many common errors using genotypes…”
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Powerful Regression-Based Quantitative-Trait Linkage Analysis of General Pedigrees by Sham, Pak C., Purcell, Shaun, Cherny, Stacey S., Abecasis, Gonçalo R.

“…We present a new method of quantitative-trait linkage analysis that combines the simplicity and robustness of regression-based methods and the generality and…”
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Combined Linkage and Association Sib-Pair Analysis for Quantitative Traits by Fulker, D.W., Cherny, S.S., Sham, P.C., Hewitt, J.K.

“…An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of…”
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Power of Linkage versus Association Analysis of Quantitative Traits, by Use of Variance-Components Models, for Sibship Data by Sham, P.C., Cherny, S.S., Purcell, S., Hewitt, J.K.

“…Optimal design of quantitative-trait loci (QTL) mapping studies requires a precise understanding of the power of QTL linkage versus QTL association analysis,…”
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Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships by Nash, Matthew W., Huezo-Diaz, Patricia, Williamson, Richard J., Sterne, Abraham, Purcell, Shaun, Hoda, Farzana, Cherny, Stacey S., Abecasis, Gonçalo R., Prince, Martin, Gray, Jeffrey A., Ball, David, Asherson, Philip, Mann, Anthony, Goldberg, David, McGuffin, Peter, Farmer, Anne, Plomin, Robert, Craig, Ian W., Sham, Pak C.

“…There is considerable evidence to suggest that the genetic vulnerabilities to depression and anxiety substantially overlap and quantitatively act to alter risk…”
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Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins by Hur, Y.M, Kaprio, J, Iacono, W.G, Boomsma, D.I, McGue, M, Silventoinen, K, Martin, N.G, Luciano, M, Visscher, P.M, Rose, R.J, He, M, Ando, J, Ooki, S, Nonaka, K, Lin, C.C.H, Lajunen, H.R

“…Objective: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were…”
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Association of CD247 with systemic lupus erythematosus in Asian populations by Li, R, Yang, W, Zhang, J, Hirankarn, N, Pan, H-F, Mok, CC, Chan, TM, Wong, RWS, Mok, MY, Lee, KW, Wong, SN, Leung, AMH, Li, X-P, Avihingsanon, Y, Lee, TL, Ho, MHK, Lee, PPW, Wong, WHS, Wong, C-M, Ng, IOL, Yang, J, Li, PH, Zhang, Y, Zhang, L, Li, W, Baum, L, Kwan, P, Rianthavorn, P, Deekajorndej, T, Suphapeetiporn, K, Shotelersuk, V, Garcia-Barceló, M-M, Cherny, SS, Tam, PK-H, Sham, PC, Lau, CS, Shen, N, Lau, YL, Ye, D-Q

“…Objective: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. CD247 (CD3Z, TCRZ) plays a vital role in…”
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Use of Multivariate Linkage Analysis for Dissection of a Complex Cognitive Trait by Marlow, Angela J., Fisher, Simon E., Francks, Clyde, MacPhie, I. Laurence, Cherny, Stacey S., Richardson, Alex J., Talcott, Joel B., Stein, John F., Monaco, Anthony P., Cardon, Lon R.

“…Replication of linkage results for complex traits has been exceedingly difficult, owing in part to the inability to measure the precise underlying phenotype,…”
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High-resolution mapping of quantitative trait loci in outbred mice by Flint, Jonathan, Talbot, Christopher J, Nicod, Alison, Cherny, Stacey S, Fulker, David W, Collins, Allan C

“…Screening the whole genome of a cross between two inbred animal strains has proved to be a powerful method for detecting genetic loci underlying quantitative…”
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Quantitative-Trait Locus for Specific Language and Reading Deficits on Chromosome 6p by Gayán, Javier, Smith, Shelley D., Cherny, Stacey S., Cardon, Lon R., Fulker, David W., Brower, Amy M., Olson, Richard K., Pennington, Bruce F., DeFries, John C.

“…Reading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals…”
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The impact of genotyping error on family-based analysis of quantitative traits by Abecasis, G R, Cherny, S S, Cardon, L R

“…Errors in genotyping can substantially influence the power to detect linkage using affected sib-pairs, but it is not clear what effect such errors have on…”
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Significant linkage to migraine with aura on chromosome 11q24 by Cader, Zameel M., Noble-Topham, Sandra, Dyment, David A., Cherny, Stacey S., Brown, John D., Rice, George P.A., Ebers, George C.

“…Migraine with aura (MA) is a prevalent neurological condition with strong evidence for a genetic basis. Familial hemiplegic migraine, a rare Mendelian form of…”
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Variance Components and Related Methods for Mapping Quantitative Trait Loci by Cherny, S.S.

“…Variance components methods have been used in various aspects of genetic analysis for many decades. This article discusses their application to data on…”
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Linkage between sexual orientation and chromosome Xq28 in males but not in females by Hu, Stella, Pattatucci, Angela M. L, Patterson, Chavis, Li, Lin, Fulker, David W, Cherny, Stacey S, Kruglyak, Leonid, Hamer, Dean H

“…We have extended our analysis of the role of the long arm of the X chromosome (Xq28) in sexual orientation by DNA linkage analyses of two newly ascertained…”
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An improved multipoint sib-pair analysis of quantitative traits by Fulker, D W, Cherny, S S

“…Kruglyak and Lander (1995) recently published a multipoint sib-pair procedure based on the expected distribution of zero, one and two marker alleles shared…”
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Multipoint interval mapping of quantitative trait loci, using sib pairs by FULKER, D. W, CHERNY, S. S, CARDON, L. R

“…The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously…”
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Increase in power through multivariate analyses by Schmitz, S, Cherny, S S, Fulker, D W

“…Power to detect genetic and environmental influences increases not only with sample size but also with the number of measurements through longitudinal and/or…”
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