Search Results - "Chernova, Tatiana A."

Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery by Chernova, Tatiana A, Chernoff, Yury O, Wilkinson, Keith D

“…Amyloids are self-perpetuating protein aggregates causing neurodegenerative diseases in mammals. Prions are transmissible protein isoforms (usually of amyloid…”
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Yeast Chaperone Hsp70-Ssb Modulates a Variety of Protein-Based Heritable Elements by Jay-Garcia, Lina M, Cornell, Joseph L, Howie, Rebecca L, Faber, Quincy L, Salas, Abigail, Chernova, Tatiana A, Chernoff, Yury O

“…Prions are transmissible self-perpetuating protein isoforms associated with diseases and heritable traits. Yeast prions and non-transmissible protein…”
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Prion Induction by the Short-Lived, Stress-Induced Protein Lsb2 Is Regulated by Ubiquitination and Association with the Actin Cytoskeleton by Chernova, Tatiana A., Romanyuk, Andrey V., Karpova, Tatiana S., Shanks, John R., Ali, Moiez, Moffatt, Nela, Howie, Rebecca L., O'Dell, Andrew, McNally, James G., Liebman, Susan W., Chernoff, Yury O., Wilkinson, Keith D.

“…Yeast prions are self-perpetuating, QN-rich amyloids that control heritable traits and serve as a model for mammalian amyloidoses. De novo prion formation by…”
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Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress by Chernova, Tatiana A., Kiktev, Denis A., Romanyuk, Andrey V., Shanks, John R., Laur, Oskar, Ali, Moiez, Ghosh, Abheek, Kim, Dami, Yang, Zhen, Mang, Maggie, Chernoff, Yury O., Wilkinson, Keith D.

“…Self-perpetuating ordered protein aggregates (amyloids and prions) are associated with a variety of neurodegenerative disorders. Although environmental agents…”
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Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association by Chernova, Tatiana A, Yang, Zhen, Karpova, Tatiana S, Shanks, John R, Shcherbik, Natalia, Wilkinson, Keith D, Chernoff, Yury O

“…Yeast prions and mnemons are respectively transmissible and non-transmissible self-perpetuating protein assemblies, frequently based on cross-β ordered…”
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Profiling and verifying the substrates of E3 ubiquitin ligase Rsp5 in yeast cells by Fang, Shuai, Chen, Geng, Wang, Yiyang, Ganti, Rakhee, Chernova, Tatiana A., Zhou, Li, Jacobs, Savannah E., Duong, Duc, Kiyokawa, Hiroaki, Chernoff, Yury O., Li, Ming, Shcherbik, Natalia, Zhao, Bo, Yin, Jun

“…Yeast is an essential model organism for studying protein ubiquitination pathways; however, identifying the direct substrates of E3 in the cell presents a…”
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Effects of Ubiquitin System Alterations on the Formation and Loss of a Yeast Prion by Allen, Kim D., Chernova, Tatiana A., Tennant, E. Paula, Wilkinson, Keith D., Chernoff, Yury O.

“…The yeast prion [PSI+] is a self-propagating amyloidogenic isoform of the translation termination factor Sup35. Overproduction of the chaperone protein Hsp104…”
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Prions, Chaperones, and Proteostasis in Yeast by Chernova, Tatiana A, Wilkinson, Keith D, Chernoff, Yury O

“…Prions are alternatively folded, self-perpetuating protein isoforms involved in a variety of biological and pathological processes. Yeast prions are…”
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Pleiotropic Effects of Ubp6 Loss on Drug Sensitivities and Yeast Prion Are Due to Depletion of the Free Ubiquitin Pool by Chernova, Tatiana A., Allen, Kim D., Wesoloski, Lisa M., Shanks, John R., Chernoff, Yury O., Wilkinson, Keith D.

“…Mutation of the mouse Usp14 gene, encoding the homolog of yeast deubiquitinating enzyme Ubp6, causes ataxia. Here we show that deletion of the UBP6 gene in…”
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Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein by Chernoff, Y.O, Galkin, A.P, Lewitin, E, Chernova, T.A, Newnam, G.P, Belenkiy, S.M

“…Saccharomyces cerevisiae prion [PSI ] is a self‐propagating isoform of the eukaryotic release factor eRF3 (Sup35p). Sup35p consists of the evolutionary…”
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BRCA1-Associated Protein-1 Is a Tumor Suppressor that Requires Deubiquitinating Activity and Nuclear Localization by VENTII, Karen H, DEVI, Narra S, FRIEDRICH, Kenneth L, CHERNOVA, Tatiana A, TIGHIOUART, Mourad, VAN MEIR, Erwin G, WILKINSON, Keith D

“…BRCA1-associated protein-1 (BAP1), a deubiquitinating enzyme of unknown cellular function, is mutated in breast and lung cancers. In this study, we have shown…”
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Physiological and environmental control of yeast prions by Chernova, Tatiana A., Wilkinson, Keith D., Chernoff, Yury O.

“…Abstract Prions are self-perpetuating protein isoforms that cause fatal and incurable neurodegenerative disease in mammals. Recent evidence indicates that a…”
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Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer by Wang, Yiyang, Fang, Shuai, Chen, Geng, Ganti, Rakhee, Chernova, Tatiana A, Zhou, Li, Duong, Duc, Kiyokawa, Hiroaki, Li, Ming, Zhao, Bo, Shcherbik, Natalia, Chernoff, Yury O, Yin, Jun

“…Attachment of the ubiquitin (UB) peptide to proteins via the E1-E2-E3 enzymatic machinery regulates diverse biological pathways, yet identification of the…”
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Distinct types of translation termination generate substrates for ribosome-associated quality control by Shcherbik, Natalia, Chernova, Tatiana A, Chernoff, Yury O, Pestov, Dimitri G

“…Cotranslational degradation of polypeptide nascent chains plays a critical role in quality control of protein synthesis and the rescue of stalled ribosomes. In…”
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Application of yeast to studying amyloid and prion diseases by Chernoff, Yury O, Grizel, Anastasia V, Rubel, Aleksandr A, Zelinsky, Andrew A, Chandramowlishwaran, Pavithra, Chernova, Tatiana A

“…Amyloids are fibrous cross-β protein aggregates that are capable of proliferation via nucleated polymerization. Amyloid conformation likely represents an…”
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To CURe or not to CURe? Differential effects of the chaperone sorting factor Cur1 on yeast prions are mediated by the chaperone Sis1 by Barbitoff, Yury A., Matveenko, Andrew G., Moskalenko, Svetlana E., Zemlyanko, Olga M., Newnam, Gary P., Patel, Ayesha, Chernova, Tatiana A., Chernoff, Yury O., Zhouravleva, Galina A.

“…Summary Yeast self‐perpetuating protein aggregates (prions) provide a convenient model for studying various components of the cellular protein quality control…”
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Prion-based memory of heat stress in yeast by Chernova, Tatiana A., Chernoff, Yury O., Wilkinson, Keith D.

“…Amyloids and amyloid-based prions are self-perpetuating protein aggregates which can spread by converting a normal protein of the same sequence into a prion…”
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Stress-dependent Proteolytic Processing of the Actin Assembly Protein Lsb1 Modulates a Yeast Prion by Ali, Moiez, Chernova, Tatiana A., Newnam, Gary P., Yin, Luming, Shanks, John, Karpova, Tatiana S., Lee, Andrew, Laur, Oskar, Subramanian, Sindhu, Kim, Dami, McNally, James G., Seyfried, Nicholas T., Chernoff, Yury O., Wilkinson, Keith D.

“…Yeast prions are self-propagating amyloid-like aggregates of Q/N-rich protein that confer heritable traits and provide a model of mammalian amyloidoses. [PSI+]…”
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Yeast studies reveal moonlighting functions of the ancient actin cytoskeleton by Sattlegger, Evelyn, Chernova, Tatiana A., Gogoi, Neeku M., Pillai, Indu V., Chernoff, Yury O., Munn, Alan L.

“…Classic functions of the actin cytoskeleton include control of cell size and shape and the internal organization of cells. These functions are manifest in…”
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Hsp70 Chaperones as Modulators of Prion Life Cycle: Novel Effects of Ssa and Ssb on the Saccharomyces cerevisiae Prion [PSI+] by Allen, Kim D, Wegrzyn, Renee D, Chernova, Tatiana A, Muller, Susanne, Newnam, Gary P, Winslett, Peggy A, Wittich, Kristin B, Wilkinson, Keith D, Chernoff, Yury O

“…[PSI(+)] is a prion isoform of the yeast release factor Sup35. In some assays, the cytosolic chaperones Ssa1 and Ssb1/2 of the Hsp70 family were previously…”
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