Search Results - "Chernov, Mikhail V"

p53 is a suppressor of inflammatory response in mice by Komarova, Elena A, Krivokrysenko, Vadim, Wang, Kaihua, Neznanov, Nickolay, Chernov, Mikhail V, Komarov, Pavel G, Brennan, Marie-Luise, Golovkina, Tatiana V, Rokhlin, Oskar W, Kuprash, Dmitry V, Nedospasov, Sergei A, Hazen, Stanley L, Feinstein, Elena, Gudkov, Andrei V

“…ABSTRACTChronic inflammation is known to promote cancer, suggesting that negative regulation of inflammation is likely to be tumor suppressive. We found that…”
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BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system by Kondratov, Roman V, Chernov, Mikhail V, Kondratova, Anna A, Gorbacheva, Victoria Y, Gudkov, Andrei V, Antoch, Marina P

“…Mammalian CLOCK and BMAL1 are two members of bHLH-PAS-containing family of transcription factors that represent the positive elements of circadian…”
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OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis by Korotchkina, Lioubov, Kazyulkin, Denis, Komarov, Pavel G., Polinsky, Alex, Andrianova, Ekaterina L., Joshi, Sangeeta, Gupta, Mahima, Vujcic, Slavoljub, Kononov, Eugene, Toshkov, Ilia, Tian, Yuan, Krasnov, Peter, Chernov, Mikhail V., Veith, Jean, Antoch, Marina P., Middlemiss, Shiloh, Somers, Klaartje, Lock, Richard B., Norris, Murray D., Henderson, Michelle J., Haber, Michelle, Chernova, Olga B., Gudkov, Andrei V.

“…Effective treatment of some types of cancer can be achieved by modulating cell lineage-specific rather than tumor-specific targets. We conducted a systematic…”
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Stabilization and Activation of p53 are Regulated Independently by Different Phosphorylation Events by Chernov, Mikhail V., Ramana, Chilakamarti V., Adler, Victor V., Stark, George R.

“…Treatment of mouse or human cells with the protein kinase C (PKC) inhibitors H7 or bisindolylmaleimide I induced an increase in the lifetime of p53, leading to…”
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A Chemical Inhibitor of p53 that Protects Mice from the Side Effects of Cancer Therapy by Komarov, Pavel G., Komarova, Elena A., Kondratov, Roman V., Christov-Tselkov, Konstantin, Coon, John S., Chernov, Mikhail V., Gudkov, Andrei V.

“…Chemotherapy and radiation therapy for cancer often have severe side effects that limit their efficacy. Because these effects are in part determined by…”
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Selection-Subtraction Approach (SSA): A Universal Genetic Screening Technique That Enables Negative Selection by Singhi, Aatur D., Kondratov, Roman V., Neznanov, Nickolay, Chernov, Mikhail V., Gudkov, Andrei V., Stark, George R.

“…Screening of expression libraries for bioactive clones that modulate the growth of mammalian cells has been limited largely to positive selections incapable of…”
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Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES by Kondratov, Roman V, Kondratova, Anna A, Lee, Choogon, Gorbacheva, Victoria Y, Chernov, Mikhail V, Antoch, Marina P

“…Mammalian CLOCK(NPAS2), BMAL1 and CRYPTOCHROMEs are core components of the circadian oscillatory mechanism. The active CLOCK/BMAL1 or NPAS2/BMAL1 complexes…”
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Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1 by Hu, Yan, Spengler, Mary L, Kuropatwinski, Karen K, Comas-Soberats, Maria, Jackson, Marilyn, Chernov, Mikhail V, Gleiberman, Anatoly S, Fedtsova, Natalia, Rustum, Youcef M, Gudkov, Andrei V, Antoch, Marina P

“…Selenium compounds are known as cancer preventive agents and are also able to ameliorate the toxicity associated with anti-cancer radiation and chemotherapy in…”
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Pharmacological modulators of the circadian clock as potential therapeutic drugs by Antoch, Marina P., Chernov, Mikhail V.

“…Circadian clocks are molecular time-keeping systems that underlie daily fluctuations in multiple physiological and biochemical processes. It is well recognized…”
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p53 Inhibitor Pifithrin α Can Suppress Heat Shock and Glucocorticoid Signaling Pathways by Komarova, Elena A., Neznanov, Nickolay, Komarov, Pavel G., Chernov, Mikhail V., Wang, Kaihua, Gudkov, Andrei V.

“…Pifithrin α (PFTα) is a chemical compound isolated for its ability to suppress p53-mediated transactivation. It can protect cells from p53-mediated apoptosis…”
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Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo by Komarova, Elena A., Chernov, Mikhail V., Franks, Roberta, Wang, Kaihua, Armin, Gabriella, Zelnick, Carolyn R., Chin, Dot M., Bacus, Sarah S., Stark, George R., Gudkov, Andrei V.

“…To analyze the involvement of p53‐dependent transcriptional activation in normal development and in response to DNA damage in vivo, we created transgenic mice…”
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Regulation of Ubiquitination and Degradation of p53 in Unstressed Cells through C-terminal Phosphorylation by Chernov, M V, Bean, L J, Lerner, N, Stark, G R

“…Previously, we found that the protein kinase C (PKC) inhibitor H7 stimulates p53 to accumulate in a form incapable of inducing transcription from p53-dependent…”
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Posttranslational Regulation of Circadian Transcriptional Clock (NPAS2)/BMAL1 Complex by Cryptochromes by Kondratov, Roman V., Kondratova, Anna A., Lee, Choogon, Gorbacheva, Victoria Y., Chernov, Mikhail V., Antoch, Marina P.

“…Mammalian CLOCK(NPAS2), BMAL1 and CRYPTOCHROMEs are core components of the circadian oscillatory mechanism. The active CLOCK/BMAL1 or NPAS2/BMAL1 complexes…”
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p53 Inhibitor Pifithrin α Can Suppress Heat Shock and Glucocorticoid Signaling Pathways by Elena A. Komarova, Nickolay Neznanov, Pavel G. Komarov, Mikhail V. Chernov, Kaihua Wang, Andrei V. Gudkov

“…Pifithrin α (PFTα) is a chemical compound isolated for its ability to suppress p53-mediated transactivation. It can protect cells from p53-mediated apoptosis…”
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Pharmacological modulators of the circadian clock as potential therapeutic drugs by Antoch, Marina P, Chernov, Mikhail V

“…Circadian clocks are molecular time-keeping systems that underlie daily fluctuations in multiple physiological and biochemical processes. It is well recognized…”
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The candidate tumour suppressor p33 ING1 cooperates with p53 in cell growth control by Gudkov, Andrei V, Garkavtsev, Igor, Grigorian, Irina A, Ossovskaya, Valeria S, Chernov, Mikhail V, Chumakov, Peter M

“…The candidate tumour-suppressor gene ING1 has been identified by using the genetic suppressor element (GSE) methodology. ING1 encodes a nuclear protein,…”
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The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control by Garkavtsev, Igor, Grigorian, Irina A., Ossovskaya, Valeria S., Chernov, Mikhail V., Chumakov, Peter M., Gudkov, Andrei V.

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The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control by Garkavtsev, I, Grigorian, I A, Ossovskaya, V S, Chernov, M V, Chumakov, P M, Gudkov, A V

“…The candidate tumour-suppressor gene ING1 has been identified by using the genetic suppressor element (GSE) methodology. ING1 encodes a nuclear protein,…”
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The candidate tumour suppressor p33 super(ING1) cooperates with p53 in cell growth control by Garkavtsev, I, Grigorian, IA, Ossovskaya, V S, Chernov, M V, Chumakov, P M, Gudkov, A V

“…The candidate tumour-suppressor gene ING1 has been identified by using the genetic suppressor element (GSE) methodology. ING1 encodes a nuclear protein, p33…”
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