Search Results - "Chernomordik, L"

Arginine-rich cell penetrating peptides: from endosomal uptake to nuclear delivery by Melikov, K, Chernomordik, L V

“…Delivery of macromolecules into living cells by arginine-rich cell penetrating peptides (AR-CPPs) is an important new avenue for the development of novel…”
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The hemifusion intermediate and its conversion to complete fusion: regulation by membrane composition by Chernomordik, L., Chanturiya, A., Green, J., Zimmerberg, J.

“…To fuse, membranes must bend. The energy of each lipid monolayer with respect to bending is minimized at the spontaneous curvature of the monolayer. Two lipids…”
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Lipids in biological membrane fusion by Chernomordik, L, Kozlov, M M, Zimmerberg, J

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Delivery of steric block morpholino oligomers by (R-X-R)₄ peptides: structure-activity studies by Abes, Rachida, Moulton, Hong M, Clair, Philippe, Yang, Sung-Tae, Abes, Said, Melikov, Kamran, Prevot, Paul, Youngblood, Derek S, Iversen, Patrick L, Chernomordik, Leonid V, Lebleu, Bernard

“…Redirecting the splicing machinery through the hybridization of high affinity, RNase H- incompetent oligonucleotide analogs such as phosphoramidate morpholino…”
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Voltage-Induced Nonconductive Pre-Pores and Metastable Single Pores in Unmodified Planar Lipid Bilayer by Melikov, Kamran C., Frolov, Vadim A., Shcherbakov, Arseniy, Samsonov, Andrey V., Chizmadzhev, Yury A., Chernomordik, Leonid V.

“…Electric fields promote pore formation in both biological and model membranes. We clamped unmodified planar bilayers at 150–550 mV to monitor transient single…”
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Electroporation and electrophoretic DNA transfer into cells. The effect of DNA interaction with electropores by Sukharev, S.I., Klenchin, V.A., Serov, S.M., Chernomordik, L.V., Chizmadzhev YuA

“…It has been shown recently that electrically induced DNA transfer into cells is a fast vectorial process with the same direction as DNA electrophoresis in an…”
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The 1−127 HA2 Construct of Influenza Virus Hemagglutinin Induces Cell−Cell Hemifusion by Leikina, Eugenia, LeDuc, Danika L, Macosko, Jed C, Epand, Raquel, Epand, Richard, Shin, Yeon-Kyun, Chernomordik, Leonid V

“…Conformational changes in the HA2 subunit of influenza hemagglutinin (HA) are coupled to membrane fusion. We investigated the fusogenic activity of the…”
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The Pathway of Membrane Fusion Catalyzed by Influenza Hemagglutinin: Restriction of Lipids, Hemifusion, and Lipidic Fusion Pore Formation by Chernomordik, Leonid V., Frolov, Vadim A., Leikina, Eugenia, Bronk, Peter, Zimmerberg, Joshua

“…The mechanism of bilayer unification in biological fusion is unclear. We reversibly arrested hemagglutinin (HA)-mediated cell-cell fusion right before fusion…”
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A Mechanism of Protein-Mediated Fusion: Coupling between Refolding of the Influenza Hemagglutinin and Lipid Rearrangements by Kozlov, Michael M., Chernomordik, Leonid V.

“…Although membrane fusion mediated by influenza virus hemagglutinin (HA) is the best characterized example of ubiquitous protein-mediated fusion, it is still…”
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Flickering Fusion Pores Comparable with Initial Exocytotic Pores Occur in Protein-Free Phospholipid Bilayers by Chanturiya, A, Chernomordik, L V, Zimmerberg, J

“…For the act of membrane fusion, there are two competing, mutually exclusive models that differ in the structure of the initial pore, the pathway for ionic…”
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Electrically induced DNA uptake by cells is a fast process involving DNA electrophoresis by Klenchin, V.A., Sukharev, S.I., Serov, S.M., Chernomordik, L.V., Chizmadzhev YuA

“…Simian Cos-1 cells were transfected electrically with the plasmid pCH110 carrying the beta-galactosidase gene. The efficiency of transfection was determined by…”
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Synchronized Activation and Refolding of Influenza Hemagglutinin in Multimeric Fusion Machines by Markovic, Ingrid, Leikina, Eugenia, Zhukovsky, Mikhail, Zimmerberg, Joshua, Chernomordik, Leonid V.

“…At the time of fusion, membranes are packed with fusogenic proteins. Do adjacent individual proteins interact with each other in the plane of the membrane? Or…”
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An amphipathic peptide from the C-terminal region of the human immunodeficiency virus envelope glycoprotein causes pore formation in membranes by Chernomordik, L, Chanturiya, A N, Suss-Toby, E, Nora, E, Zimmerberg, J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An Early Stage of Membrane Fusion Mediated by the Low pH Conformation of Influenza Hemagglutinin Depends upon Membrane Lipids by Chernomordik, Leonid V., Leikina, Eugenia, Frolov, Vadim, Bronk, Peter, Zimmerberg, Joshua

“…While the specificity and timing of membrane fusion in diverse physiological reactions, including virus-cell fusion, is determined by proteins, fusion always…”
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Lysophosphatidylcholine reversibly arrests exocytosis and viral fusion at a stage between triggering and membrane merger by Vogel, S S, Leikina, E A, Chernomordik, L V

“…Little is known of the events occurring between membrane fusion triggering and subsequent fusion steps. To dissect this process we applied a reversible…”
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Control of baculovirus gp64-induced syncytium formation by membrane lipid composition by Chernomordik, L. (National Institute of Child Health and Human Development, Bethesda, MD.), Leikina, E, Cho, M.S, Zimmerberg, J

“…We have investigated the effects of membrane lipid composition on biological membrane fusion triggered by low pH and mediated by the baculovirus envelope…”
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Reversible electrical breakdown of lipid bilayers: formation and evolution of pores by Glaser, R W, Leikin, S L, Chernomordik, L V, Pastushenko, V F, Sokirko, A I

“…The mechanism of reversible electric breakdown of lipid membranes is studied. The following stages of the process of pore development are substantiated…”
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Reversible merger of membranes at the early stage of influenza hemagglutinin-mediated fusion by Leikina, E, Chernomordik, L V

“…Fusion mediated by influenza hemagglutinin (HA), a prototype fusion protein, is commonly detected as lipid and content mixing between fusing cells. Decreasing…”
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Membrane Fusion Mediated by Baculovirus gp64 Involves Assembly of Stable gp64 Trimers into Multiprotein Aggregates by Markovic, Ingrid, Pulyaeva, Helena, Sokoloff, Alexander, Chernomordik, Leonid V.

“…The baculovirus fusogenic activity depends on the low pH conformation of virally-encoded trimeric glycoprotein, gp64. We used two experimental approaches to…”
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Bending membranes to the task: structural intermediates in bilayer fusion by Chernomordik, Leonid V, Zimmerberg, Joshua

“…Merger of lipid bilayers plays a central role in diverse biological fusion reactions. Recent studies suggest that different membrane fusion systems, including…”
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