Search Results - "Chernolovskaya, Elena L"

Activation of Innate Immunity by Therapeutic Nucleic Acids by Bishani, Ali, Chernolovskaya, Elena L

“…Nucleic acid-based therapeutics have gained increased attention during recent decades because of their wide range of application prospects. Immunostimulatory…”
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Current Development of siRNA Bioconjugates: From Research to the Clinic by Chernikov, Ivan V, Vlassov, Valentin V, Chernolovskaya, Elena L

“…Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to recognize a homologous mRNA sequence in the cell and induce its degradation…”
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Structural Modifications of siRNA Improve Its Performance In Vivo by Chernikov, Ivan V, Ponomareva, Ulyana A, Chernolovskaya, Elena L

“…The use of small interfering RNA (siRNA) in the clinic gives a wide range of possibilities for the treatment of previously incurable diseases. However, the…”
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The Impact of Chemical Modifications on the Interferon-Inducing and Antiproliferative Activity of Short Double-Stranded Immunostimulating RNA by Bishani, Ali, Meschaninova, Mariya I, Zenkova, Marina A, Chernolovskaya, Elena L

“…A short 19 bp dsRNA with 3'-trinucleotide overhangs acting as immunostimulating RNA (isRNA) demonstrated strong antiproliferative action against cancer cells,…”
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A Versatile Solid-Phase Approach to the Synthesis of Oligonucleotide Conjugates with Biodegradable Hydrazone Linker by Meschaninova, Mariya I, Entelis, Nina S, Chernolovskaya, Elena L, Venyaminova, Alya G

“…One of the ways to efficiently deliver various drugs, including therapeutic nucleic acids, into the cells is conjugating them with different transport ligands…”
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Cholesterol Conjugates of Small Interfering RNA: Linkers and Patterns of Modification by Chernikov, Ivan V, Ponomareva, Ul'yana A, Meschaninova, Mariya I, Bachkova, Irina K, Vlassov, Valentin V, Zenkova, Marina A, Chernolovskaya, Elena L

“…Cholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we…”
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Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene by Chernikov, Ivan V., Gladkikh, Daniil V., Meschaninova, Mariya I., Ven'yaminova, Alya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

“…Chemical modifications are an effective way to improve the therapeutic properties of small interfering RNAs (siRNAs), making them more resistant to degradation…”
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siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury by Chernikov, Ivan V, Staroseletz, Yaroslav Yu, Tatarnikova, Irina S, Sen'kova, Aleksandra V, Savin, Innokenty A, Markov, Andrey V, Logashenko, Evgeniya B, Chernolovskaya, Elena L, Zenkova, Marina A, Vlassov, Valentin V

“…Acute lung injury is a complex cascade process that develops in response to various damaging factors, which can lead to acute respiratory distress syndrome…”
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Transport Oligonucleotides-A Novel System for Intracellular Delivery of Antisense Therapeutics by Markov, Oleg V, Filatov, Anton V, Kupryushkin, Maxim S, Chernikov, Ivan V, Patutina, Olga A, Strunov, Anton A, Chernolovskaya, Elena L, Vlassov, Valentin V, Pyshnyi, Dmitrii V, Zenkova, Marina A

“…Biological activity of antisense oligonucleotides (asON), especially those with a neutral backbone, is often attenuated by poor cellular accumulation. In the…”
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Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells by Kupryushkin, Maxim S., Filatov, Anton V., Mironova, Nadezhda L., Patutina, Olga A., Chernikov, Ivan V., Chernolovskaya, Elena L., Zenkova, Marina A., Pyshnyi, Dmitrii V., Stetsenko, Dmitry A., Altman, Sidney, Vlassov, Valentin V.

“…Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic…”
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Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group by Petrova, Natalya S., Chernikov, Ivan V., Meschaninova, Mariya I., Dovydenko, IIya S., Venyaminova, Aliya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

“…The conjugation of siRNA to molecules, which can be internalized into the cell via natural transport mechanisms, can result in the enhancement of siRNA…”
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Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity by Chernikov, Ivan V, Gladkikh, Daniil V, Karelina, Ulyana A, Meschaninova, Mariya I, Ven'yaminova, Alya G, Vlassov, Valentin V, Chernolovskaya, Elena L

“…Cholesterol derivatives of nuclease-resistant, anti- small-interfering RNAs were designed to contain a 2'-OMe-modified 21-bp siRNA and a 63-bp TsiRNA in order…”
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Antitumor and Antimetastatic Effect of Small Immunostimulatory RNA against B16 Melanoma in Mice by Kabilova, Tatyana O, Sen'kova, Aleksandra V, Nikolin, Valeriy P, Popova, Nelly A, Zenkova, Marina A, Vlassov, Valentin V, Chernolovskaya, Elena L

“…Small interfering RNAs, depending on their structure, delivery system and sequence, can stimulate innate and adaptive immunity. The aim of this study was to…”
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Molecular Mechanism of the Antiproliferative Activity of Short Immunostimulating dsRNA by Zharkov, Mikhail I, Zenkova, Marina A, Vlassov, Valentin V, Chernolovskaya, Elena L

“…Small double-stranded RNAs with certain sequence motifs are able to interact with pattern-recognition receptors and activate the innate immune system…”
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Nuclease‐resistant 63‐bp trimeric siRNAs simultaneously silence three different genes in tumor cells by Gvozdeva, Olga V., Gladkih, Daniil V., Chernikov, Ivan V., Meschaninova, Mariya I., Venyaminova, Alya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

“…We designed a multimeric nuclease‐resistant 63‐bp trimeric small‐interfering RNA (tsiRNA) comprising in one duplex the sequence of siRNAs targeting mRNAs of…”
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Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA by Bishani, Ali, Makarova, Darya M, Shmendel, Elena V, Maslov, Mikhail A, Sen‘kova, Aleksandra V, Savin, Innokenty A, Gladkikh, Daniil V, Zenkova, Marina A, Chernolovskaya, Elena L

“…In this study, the impact of different delivery systems on the cytokine-inducing, antiproliferative, and antitumor activities of short immunostimulatory…”
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Cholesterol-Modified Anti-Il6 siRNA Reduces the Severity of Acute Lung Injury in Mice by Chernikov, Ivan V, Bachkova, Irina K, Sen'kova, Aleksandra V, Meschaninova, Mariya I, Savin, Innokenty A, Vlassov, Valentin V, Zenkova, Marina A, Chernolovskaya, Elena L

“…Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target genes through RNA interference. Current clinical applications of…”
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Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of Chemotherapy by Gladkikh, Daniil V., Sen′kova, Aleksandra V., Chernikov, Ivan V., Kabilova, Tatyana O., Popova, Nelly A., Nikolin, Valery P., Shmendel, Elena V., Maslov, Mikhail A., Vlassov, Valentin V., Zenkova, Marina A., Chernolovskaya, Elena L.

“…In this study, we examined the in vivo toxicity of the liposomes F consisting of 1,26-bis(cholest-5-en-3-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan…”
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Immunostimulating RNA Delivered by P1500 PEGylated Cationic Liposomes Limits Influenza Infection in C57Bl/6 Mice by Goncharova, Elena P, Sen'kova, Aleksandra V, Savin, Innokenty A, Kabilova, Tat'yana O, Zenkova, Marina A, Vlassov, Valentin V, Chernolovskaya, Elena L

“…The emergence of highly pathogenic viruses and a high speed of infection spread put forward the problem of the development of novel antivirals and their…”
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42- and 63-bp anti-MDR1-siRNAs bearing 2′-OMe modifications in nuclease-sensitive sites induce specific and potent gene silencing by Gvozdeva, Olga V., Dovydenko, IIya S., Venyaminova, Alya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

“…•We design selectively 2′-O-methyl modified 42 and 63bp anti-MDR1-siRNAs.•We examine their ability to silence the expression of the target gene and the…”
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