Search Results - "Chernikov, Ivan V"

Current Development of siRNA Bioconjugates: From Research to the Clinic by Chernikov, Ivan V, Vlassov, Valentin V, Chernolovskaya, Elena L

“…Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to recognize a homologous mRNA sequence in the cell and induce its degradation…”
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Structural Modifications of siRNA Improve Its Performance In Vivo by Chernikov, Ivan V, Ponomareva, Ulyana A, Chernolovskaya, Elena L

“…The use of small interfering RNA (siRNA) in the clinic gives a wide range of possibilities for the treatment of previously incurable diseases. However, the…”
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Symmetric lipophilic polyamines exhibiting antitumor activity by Perevoshchikova, Ksenia A., Eshtukova-Shcheglova, Elizaveta A., Markov, Oleg V., Markov, Andrey V., Chernikov, Ivan V., Maslov, Mikhail A., Zenkova, Marina A.

“…[Display omitted] Unsymmetric lipophilic polyamine derivatives are considered as potential antitumor agents. Here, a series of novel symmetric lipophilic…”
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Cholesterol Conjugates of Small Interfering RNA: Linkers and Patterns of Modification by Chernikov, Ivan V, Ponomareva, Ul'yana A, Meschaninova, Mariya I, Bachkova, Irina K, Vlassov, Valentin V, Zenkova, Marina A, Chernolovskaya, Elena L

“…Cholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we…”
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Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene by Chernikov, Ivan V., Gladkikh, Daniil V., Meschaninova, Mariya I., Ven'yaminova, Alya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

“…Chemical modifications are an effective way to improve the therapeutic properties of small interfering RNAs (siRNAs), making them more resistant to degradation…”
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siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury by Chernikov, Ivan V, Staroseletz, Yaroslav Yu, Tatarnikova, Irina S, Sen'kova, Aleksandra V, Savin, Innokenty A, Markov, Andrey V, Logashenko, Evgeniya B, Chernolovskaya, Elena L, Zenkova, Marina A, Vlassov, Valentin V

“…Acute lung injury is a complex cascade process that develops in response to various damaging factors, which can lead to acute respiratory distress syndrome…”
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Soloxolone Methyl Reduces the Stimulatory Effect of Leptin on the Aggressive Phenotype of Murine Neuro2a Neuroblastoma Cells via the MAPK/ERK1/2 Pathway by Odarenko, Kirill V, Salomatina, Oksana V, Chernikov, Ivan V, Salakhutdinov, Nariman F, Zenkova, Marina A, Markov, Andrey V

“…Despite the proven tumorigenic effect of leptin on epithelial-derived cancers, its impact on the aggressiveness of neural crest-derived cancers, notably…”
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Transport Oligonucleotides-A Novel System for Intracellular Delivery of Antisense Therapeutics by Markov, Oleg V, Filatov, Anton V, Kupryushkin, Maxim S, Chernikov, Ivan V, Patutina, Olga A, Strunov, Anton A, Chernolovskaya, Elena L, Vlassov, Valentin V, Pyshnyi, Dmitrii V, Zenkova, Marina A

“…Biological activity of antisense oligonucleotides (asON), especially those with a neutral backbone, is often attenuated by poor cellular accumulation. In the…”
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Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells by Kupryushkin, Maxim S., Filatov, Anton V., Mironova, Nadezhda L., Patutina, Olga A., Chernikov, Ivan V., Chernolovskaya, Elena L., Zenkova, Marina A., Pyshnyi, Dmitrii V., Stetsenko, Dmitry A., Altman, Sidney, Vlassov, Valentin V.

“…Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic…”
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Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group by Petrova, Natalya S., Chernikov, Ivan V., Meschaninova, Mariya I., Dovydenko, IIya S., Venyaminova, Aliya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

“…The conjugation of siRNA to molecules, which can be internalized into the cell via natural transport mechanisms, can result in the enhancement of siRNA…”
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Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity by Chernikov, Ivan V, Gladkikh, Daniil V, Karelina, Ulyana A, Meschaninova, Mariya I, Ven'yaminova, Alya G, Vlassov, Valentin V, Chernolovskaya, Elena L

“…Cholesterol derivatives of nuclease-resistant, anti- small-interfering RNAs were designed to contain a 2'-OMe-modified 21-bp siRNA and a 63-bp TsiRNA in order…”
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1-Hydroxyanthraquinones Containing Aryl Substituents as Potent and Selective Anticancer Agents by Sirazhetdinova, Nafisa S, Savelyev, Victor A, Frolova, Tatyana S, Baev, Dmitry S, Klimenko, Lyubov S, Chernikov, Ivan V, Oleshko, Olga S, Sarojan, Teresa A, Pokrovskii, Andrey G, Shults, Elvira E

“…A series of 1,2-, 1,4-disubstituted or 1,2,4-trisubstituted anthraquinone-based compounds was designed, synthesized, characterized and biologically evaluated…”
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Nuclease‐resistant 63‐bp trimeric siRNAs simultaneously silence three different genes in tumor cells by Gvozdeva, Olga V., Gladkih, Daniil V., Chernikov, Ivan V., Meschaninova, Mariya I., Venyaminova, Alya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

“…We designed a multimeric nuclease‐resistant 63‐bp trimeric small‐interfering RNA (tsiRNA) comprising in one duplex the sequence of siRNAs targeting mRNAs of…”
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A Novel 3-meta-Pyridine-1,2,4-oxadiazole Derivative of Glycyrrhetinic Acid as a Safe and Promising Candidate for Overcoming P‑Glycoprotein-Mediated Multidrug Resistance in Tumor Cells by Moralev, Arseny D., Salomatina, Oksana V., Chernikov, Ivan V., Salakhutdinov, Nariman F., Zenkova, Marina A., Markov, Andrey V.

“…Given the pharmacophore properties of the nitrogen-containing moiety in the molecular structure of P-glycoprotein (P-gp) inhibitors, we report the evaluation…”
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Cholesterol-Modified Anti-Il6 siRNA Reduces the Severity of Acute Lung Injury in Mice by Chernikov, Ivan V, Bachkova, Irina K, Sen'kova, Aleksandra V, Meschaninova, Mariya I, Savin, Innokenty A, Vlassov, Valentin V, Zenkova, Marina A, Chernolovskaya, Elena L

“…Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target genes through RNA interference. Current clinical applications of…”
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Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of Chemotherapy by Gladkikh, Daniil V., Sen′kova, Aleksandra V., Chernikov, Ivan V., Kabilova, Tatyana O., Popova, Nelly A., Nikolin, Valery P., Shmendel, Elena V., Maslov, Mikhail A., Vlassov, Valentin V., Zenkova, Marina A., Chernolovskaya, Elena L.

“…In this study, we examined the in vivo toxicity of the liposomes F consisting of 1,26-bis(cholest-5-en-3-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan…”
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Preparation, Determination of Activity, and Biodistribution of Cholesterol-Containing Nuclease-Resistant siRNAs In Vivo by Chernikov, Ivan V, Meschaninova, Mariya I, Chernolovskaya, Elena L

“…RNA interference (RNAi) is a powerful tool for suppressing gene expression associated with various diseases that are not amenable to treatment with low…”
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Cholesterol-Conjugated Supramolecular Multimeric siRNAs: Effect of siRNA Length on Accumulation and Silencing In Vitro and In Vivo by Chernikov, Ivan V, Ponomareva, Ul'yana A, Meschaninova, Mariya I, Bachkova, Irina K, Teterina, Anna A, Gladkikh, Daniil V, Savin, Innokenty A, Vlassov, Valentin V, Zenkova, Marina A, Chernolovskaya, Elena L

“…Conjugation of small interfering RNA (siRNA) with lipophilic molecules is one of the most promising approaches for delivering siRNA . The rate of molecular…”
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Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma by Stepanov, Alexey V, Markov, Oleg V, Chernikov, Ivan V, Gladkikh, Daniil V, Zhang, Hongkai, Jones, Teresa, Sen'kova, Alexandra V, Chernolovskaya, Elena L, Zenkova, Marina A, Kalinin, Roman S, Rubtsova, Maria P, Meleshko, Alexander N, Genkin, Dmitry D, Belogurov, Jr, Alexey A, Xie, Jia, Gabibov, Alexander G, Lerner, Richard A

“…We report the development of a novel platform to enhance the efficacy and safety of follicular lymphoma (FL) treatment. Since lymphoma is a clonal malignancy…”
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Nuclease‐resistant 63‐bp trimeric si RNA s simultaneously silence three different genes in tumor cells by Gvozdeva, Olga V., Gladkih, Daniil V., Chernikov, Ivan V., Meschaninova, Mariya I., Venyaminova, Alya G., Zenkova, Marina A., Vlassov, Valentin V., Chernolovskaya, Elena L.

“…We designed a multimeric nuclease‐resistant 63‐bp trimeric small‐interfering RNA (tsi RNA ) comprising in one duplex the sequence of si RNA s targeting mRNA s…”
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