Search Results - "Cherney, B"

Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment by SAIJUN FAN, CHERNEY, B, REINHOLD, W, RUCKER, K, O'CONNOR, P. M

“…In the present study, we report our findings on the impact of p53 disruption on the sensitivity of human cell lines to the antimitotic agents Taxol and…”
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cDNA Sequence, Protein Structure, and Chromosomal Location of the Human Gene for poly(ADP-ribose) Polymerase by Cherney, Barry W., McBride, O. Wesley, Chen, Defeng, Alkhatib, Hussein, Bhatia, Kishor, Hensley, Preston, Smulson, Mark E.

“…Recently we described a full-length cDNA for the human nuclear enzyme poly(ADP-ribose) polymerase. Here, we report the chromosomal localization and partial map…”
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Role of the p53 tumor suppressor gene in the tumorigenicity of Burkitt's lymphoma cells by CHERNEY, B. W, BHATIA, K. G, SGADARI, C, GUTIERREZ, M. I, MOSTOWSKI, H, PIKE, S. E, GUPTA, G, MAGRATH, I. T, TOSATO, G

“…Burkitt's lymphoma (BL) cell lines carry a translocated c-myc gene and, in 60-80% of cases, exhibit mutations in the p53 tumor suppressor gene. We examined the…”
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Interferon-Inducible Protein-10 Identified as a Mediator of Tumor Necrosis in vivo by Sgadari, Cecilia, Angiolillo, Anne L., Cherney, Barry W., Pike, Sandra E., Farber, Joshua M., Koniaris, Leonidas G., Vanguri, Padmavathy, Burd, Parris R., Sheikh, Nasreen, Gupta, Ghanshyam, Teruya-Feldstein, Julie, Tosato, Giovanna

“…Human Burkitt lymphoma cell lines give rise to progressively growing subcutaneous tumors in athymic mice. These tumors are induced to regress by inoculation of…”
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A Role for Deregulated c-Myc Expression in Apoptosis of Epstein-Barr Virus-Immortalized B Cells by Cherney, Barry W., Bhatia, Kishor, Tosato, Giovanna

“…When deprived of autocrine growth factors, Epstein-Barr virus (EBV)-immortalized B cells stop growing and die. In this study, we show that death of…”
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Intraclonal molecular heterogeneity suggests a hierarchy of pathogenetic events in Burkitt's lymphoma by Gutiérrez, M. I., Bhatia, K., Cherney, B., Capello, D., Gaidano, G., Magrath, I.

“…Background Burkitt's lymphoma is a B-cell neoplasm characterized by a chromosomal translocation involving the c-myc gene. BL may carry, besides the c-myc…”
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Application of quality by design in the control of adventitious viruses: gaps in current processes in the prevention of virus contaminants by Cherney, Barry

“…CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December…”
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Evolution of analytical tools by MediQual Systems, Inc by Steen, P, Cherney, B

“…Over the last two decades purchasers, both private and public, have become increasingly involved in the provision of health care. Their major concern was…”
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A duplicated region is responsible for the poly(ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer by LYN, D, CHERNEY, B. W, LALANDE, M, BERENSON, J. R, LICHTENSTEIN, A, LUPOLD, S, BHATIA, K. G, SMULSON, M

“…The poly(ADP-ribose) polymerase (PADPRP) gene (13q33-qter) depicts a two-allele (A/B) polymorphism. In the noncancer population, the frequency of the B allele…”
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Establishing Patient Centric Specifications for Drug Substance and Drug Product Impurities by Bercu, J., Berlam, S. C., Berridge, J., Cherney, B., Cowley, D., Laughton, H. W., McLoughlin, D., McMahon, M., Moore, C. M. V., Murti, C., O’Neill, J., Parsons, R., Peng, D. Y., Quan, R. W., Subashi, A. K., Teasdale, A., Tyler, S. M., Watson, T. J.

“…In this paper, we remind readers of several ICH guideline documents such as ICH Q3A, Q3B, Q3C, Q3D, Q6A, Q6B, M7, and ICH S9 which are related to the drug…”
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Expression of the Epstein-Barr Virus Protein LMP1 Mediates Tumor Regression In Vivo by Cherney, Barry W., Sgadari, Cecilia, Kanegane, Chiharu, Wang, Frederick, Tosato, Giovanna

“…By stimulating the expression of murine IP-10 and Mig, CXC chemokines that inhibit neovascularization and cause damage to established tumor vasculature, human…”
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Creating a Holistic Extractables and Leachables (E&L) Program for Biotechnology Products by Li, Kim, Rogers, Gary, Nashed-Samuel, Yasser, Lee, Hans, Mire-Sluis, Anthony, Cherney, Barry, Forster, Ronald, Yeh, Ping, Markovic, Ingrid

“…The risk mitigation of extractables and leachables presents significant challenges to regulators and drug manufacturers with respect to the development, as…”
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Cloning and Expression of cDNA for Human Poly(ADP-ribose) Polymerase by Alkhatib, Hussein M., Chen, Defeng, Cherney, Barry, Bhatia, Kishor, Notario, Vicente, Giri, Chandrakant, Stein, Gary, Slattery, Elizabeth, Roeder, Robert G., Smulson, Mark E.

“…cDNAs encoding poly(ADP-ribose) polymerase from a human hepatoma λ gt11 cDNA library were isolated by immunological screening. One insert of 1.3 kilobases (kb)…”
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Expression and mutagenesis of human poly(ADP-ribose) polymerase as a ubiquitin fusion protein from Escherichia coli by Cherney, Barry W, Chaudhry, Bushra, Bhatia, Kishor, Butt, Tauseef R, Smulson, Mark

“…The cDNA of human poly(ADP-ribose) polymerase (pADPRP), encoding the entire protein, was subcloned into the Escherichia coli expression plasmid pYUb. In this…”
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Cell cycle regulation of an exogenous human poly(ADP-ribose) polymerase cDNA introduced into murine cells by Bhatia, K, Kang, V H, Stein, G S, Bustin, M, Cherney, B W, Notario, V, Haque, S J, Huppi, K, Smulson, M E

“…We have evaluated the regulation of expression of the poly(ADP-ribose) polymerase gene during cell growth and replication. In a synchronized population of HeLa…”
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Expression and characterization of a fusion protein between the catalytic domain of poly(ADP-ribose) polymerase and the DNA binding domain of the glucocorticoid receptor by Rosenthal, D, Hong, T, Cherney, B, Zhang, S, Shima, T, Danielsen, M, Smulson, M

“…A fusion protein comprising the DNA-binding region of the glucocorticoid receptor and the catalytic domain of poly(ADP-ribose) polymerase was constructed. This…”
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Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth by Pike, S E, Yao, L, Jones, K D, Cherney, B, Appella, E, Sakaguchi, K, Nakhasi, H, Teruya-Feldstein, J, Wirth, P, Gupta, G, Tosato, G

“…An endothelial cell inhibitor was purified from supernatant of an Epstein-Barr virus-immortalized cell line and identified as fragments of calreticulin. The…”
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Sequence analysis of the junction of the large single copy region and the large inverted repeat in the petunia chloroplast genome by Aldrich, J, Cherney, B.W, Williams, C, Merlin, E

“…We have determined the nucleotide sequence at the junction of the large single copy (LSC) region and the right and left members of the large inverted repeat,…”
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role of insertions/deletions in the evolution of the intergenic region between psbA and trnH in the chloroplast genome by Aldrich, J, Cherney, B.W, Merlin, E, Christopherson, L

“…TrnH and the intergenic region between trnH and psbA of the chloroplast genomes of alfalfa (Medicago sativa), Fabaceae, and petunia (Petunia hybrida),…”
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Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth by PIKE, S. E, LEI YAO, WIRTH, P, GUPTA, G, TOSATO, G, SETSUDA, J, JONES, K. D, CHERNEY, B, APPELLA, E, SAKAGUCHI, K, NAKHASI, H, ATREYA, C. D, TERUYA-FELDSTEIN, J

“…Several angiogenesis inhibitors are fragments of larger proteins that are themselves not active as angiogenesis inhibitors. Vasostatin, the N-terminal domain…”
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