Profile of chromosomal aberrations in different gestational age spontaneous abortions detected by comparative genomic hybridization

Abstract Objective To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions. Study design In the study, 106 spontaneous abortions (SAs) were studied by comparative genomic hybridization. Results The frequency of detected chromosomal aberration...

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Published in:	European journal of obstetrics & gynecology and reproductive biology Vol. 131; no. 2; pp. 127 - 131
Main Authors:	Azmanov, Dimitar N, Milachich, Tania V, Zaharieva, Boriana M, Michailova, Gergana I, Dimitrova, Violeta G, Karagiozova, Zivka H, Maznejkova, Valentina T, Chernev, Todor A, Toncheva, Draga I
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01-04-2007 Elsevier
Subjects:	Abortion, Spontaneous - genetics Adult Aneuploidy Biological and medical sciences Chromosomal aberrations Chromosome Aberrations - statistics & numerical data Chromosomes, Human, X Comparative genomic hybridization Diseases of mother, fetus and pregnancy DNA - genetics DNA Fingerprinting - methods Female Gestational Age Gynecology. Andrology. Obstetrics Humans Medical sciences Monosomy Nucleic Acid Hybridization - methods Obstetrics and Gynecology Pregnancy Pregnancy Trimester, First - genetics Pregnancy Trimester, Second - genetics Pregnancy. Fetus. Placenta Spontaneous abortions Comparative genomic hybridization Chromosomal aberrations Spontaneous abortions Chromosomal aberration Pregnancy disorders Gynecology Developmental stage Gene expression Abortion Obstetrics Gestational age
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Summary:	Abstract Objective To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions. Study design In the study, 106 spontaneous abortions (SAs) were studied by comparative genomic hybridization. Results The frequency of detected chromosomal aberrations was 37.7%. Numerical chromosomal aberrations were disclosed in 82.5% of the aberrant cases, while structural chromosomal aberrations-in 17.5%. Highest frequency of aberrations was detected in the blighted ovum specimens (62.5%) compared to missed and second trimester SAs (respectively, 36.0% and 34.8%). With regard to structural aberrations, the difference in the frequencies between blighted ovum specimens and second trimester SAs nearly reached statistical significance ( p = 0.0847). However, due to the low number of blighted ovum specimens analyzed ( n = 8), this result should be interpreted with due caution. The most frequently affected chromosomal arms were Xp and Xq (13.7% of aberrant chromosomal arms, each), followed by 16p (8.4%), 16q (8.4%), 15q (4.2%) and 19q (4.2%). Conclusions We describe for the first time a profile of chromosomal aberrations in SAs from different gestational ages, detected by CGH. Our results showed highest frequency of chromosome aberrations in blighted ovum specimens compared to other types of spontaneous abortions, higher rate of structural aberrations than reported before (17.5%) and some aberrations that so far were not found by CGH.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0301-2115 1872-7654
DOI:	10.1016/j.ejogrb.2006.04.037