Search Results - "Cherian, George M."

Metallothionein and liver cell regeneration by Cherian, M George, Kang, Y James

“…Hepatocytes in adults are in a nonproliferative state but they have high capacity to regenerate within few hours after an injury. After partial hepatectomy or…”
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P53 mediated regulation of metallothionein transcription in breast cancer cells by Ostrakhovitch, Elena A., Olsson, Per-Erik, von Hofsten, Jonas, Cherian, M. George

“…Recent studies have shown that only breast cancer epithelial cells with intact p53 can induce metallothionein (MT) synthesis after exposure to metals. In this…”
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A review of cinnabar (HgS) and/or realgar (As4S4)-containing traditional medicines by Liu, Jie, Wei, Li-Xin, Wang, Qi, Lu, Yuan-Fu, Zhang, Feng, Shi, Jing-Zhen, Li, Cen, Cherian, M. George

“…Herbo-metallic preparations have a long history in the treatment of diseases, and are still used today for refractory diseases, as adjuncts to standard…”
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Induction of functional MT1 and MT2 isoforms by calcium in anaplastic thyroid carcinoma cells by Liu, Zhi-Min, Chen, George G., Shum, Cathy K.Y., Vlantis, Alexander C., George Cherian, M., Koropatnick, James, Andrew van Hasselt, C.

“…Metallothionein (MT) expression in carcinogenesis of thyrocytes is unknown. We demonstrated that cadmium induced transcription of all functional MT-1 and MT-2…”
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Impaired hepatic regeneration in metallothionein-I/II knockout mice after partial hepatectomy by Oliver, Jordan R, Mara, Tom W, Cherian, M George

“…Although the translocation of metallothionein (MT) from cytoplasm to nucleus has been demonstrated in liver during times of high requirement for zinc (fetal…”
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Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications by Yang, Lina, Li, Hongyan, Yu, Ting, Zhao, Haijun, Cherian, M George, Cai, Lu, Liu, Ya

“…Metallothionein (MT) as a potent antioxidant can affect energy metabolism. The present study was undertaken to investigate the association between MT gene…”
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Metallothionein induction is not involved in cadmium accumulation in the duodenum of mice and rats fed diets containing high-cadmium rice or sunflower kernels and a marginal supply of zinc, iron, and calcium by Reeves, Philip G, Chaney, Rufus L, Simmons, Robert W, Cherian, M George

“…Rats fed diets with cadmium (Cd) concentrations similar to that found in human diets, and nutritionally marginal with respect to iron (Fe), zinc (Zn), and…”
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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework by Calabrese, Edward J., Bachmann, Kenneth A., Bailer, A. John, Bolger, P. Michael, Borak, Jonathan, Cai, Lu, Cedergreen, Nina, Cherian, M. George, Chiueh, Chuang C., Clarkson, Thomas W., Cook, Ralph R., Diamond, David M., Doolittle, David J., Dorato, Michael A., Duke, Stephen O., Feinendegen, Ludwig, Gardner, Donald E., Hart, Ronald W., Hastings, Kenneth L., Hayes, A. Wallace, Hoffmann, George R., Ives, John A., Jaworowski, Zbigniew, Johnson, Thomas E., Jonas, Wayne B., Kaminski, Norbert E., Keller, John G., Klaunig, James E., Knudsen, Thomas B., Kozumbo, Walter J., Lettieri, Teresa, Liu, Shu-Zheng, Maisseu, Andre, Maynard, Kenneth I., Masoro, Edward J., McClellan, Roger O., Mehendale, Harihara M., Mothersill, Carmel, Newlin, David B., Nigg, Herbert N., Oehme, Frederick W., Phalen, Robert F., Philbert, Martin A., Rattan, Suresh I.S., Riviere, Jim E., Rodricks, Joseph, Sapolsky, Robert M., Scott, Bobby R., Seymour, Colin, Sinclair, David A., Smith-Sonneborn, Joan, Snow, Elizabeth T., Spear, Linda, Stevenson, Donald E., Thomas, Yolene, Tubiana, Maurice, Williams, Gary M., Mattson, Mark P.

“…Many biological subdisciplines that regularly assess dose–response relationships have identified an evolutionarily conserved process in which a low dose of a…”
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P53 mediated regulation of metalolothionen transcription in breast cancer cells by Ostrakhovitch, Elena A, Olsson, Per-Erik, von Hofsten, Jonas, Cherian, M George

“…Recent studies have shown that only breast cancer epithelial cells with intact p53 can induce metallothionein (MT) synthesis after exposure to metals. In this…”
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Essentiality, toxicology and chelation therapy of zinc and copper by Cai, Lu, Li, Xiao-Kun, Song, Ye, Cherian, M George

“…Both zinc and copper are essential minerals that are required for various cellular functions. Although these metals are essential, they can be toxic at excess…”
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Interaction of metallothionein with tumor suppressor p53 protein by Ostrakhovitch, Elena A., Olsson, Per-Erik, Jiang, Sean, Cherian, M. George

“…Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between…”
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Regional distribution of metallothionein, zinc, and copper in the brain of different strains of rats by Ono, S, Cherian, M G

“…The regional brain distribution of metallothionein (MT), zinc, and copper in the brain was determined in nine anatomical regions (olfactory bulb, cortex,…”
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Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: The lack of effect of ERK in p53 mediated copper induced apoptosis by Ostrakhovitch, Elena A., Cherian, M. George

“…Recent studies have shown that MEK/ERK‐mediated signals play a major role in regulation of activity of p53 tumor suppressor protein. In this study, we…”
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Signal transduction pathways, and nuclear translocation of zinc and metallothionein during differentiation of myoblasts by Apostolova, M D, Ivanova, I A, Cherian, M G

“…The changes in subcellular localization of metallothionein during differentiation were studied in two myoblast cell lines, L6 and H9C2. Addition of insulin…”
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Zinc-metallothionein protects from DNA damage induced by radiation better than glutathione and copper- or cadmium-metallothioneins by Cai, Lu, Cherian, M.George

“…Protection of radiation-induced DNA damage by metallothionein (MT) has been documented, but there is no detailed information about its efficiency compared to…”
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Expression of functional metallothionein isoforms in papillary thyroid cancer by Liu, Zhi-Min, Hasselt, C. Andrew van, Song, Fang-Zhou, Vlantis, Alexander C., Cherian, M. George, Koropatnick, James, Chen, George G.

“…Metallothionein (MT) isoforms have not been studied in papillary thyroid cancer. We examined how the functional MT1 and MT2 isoforms were expressed in…”
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Markers of chemoresistance in ovarian carcinomas: an immunohistochemical study of 86 cases by Germain, I, Têtu, B, Brisson, J, Mondor, M, Cherian, M G

“…Markers of chemoresistance have been rarely investigated in human ovarian cancer. This study evaluates the clinical value in ovarian cancer of metallothionein…”
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Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide by Oliver, Jordan R., Jiang, Sean, Cherian, M. George

“…A previous study (Oliver, J.R., Mara, T.W., Cherian, M.G. 2005. Impaired hepatic regeneration in metallothionein-I/II knockout mice after partial hepatectomy…”
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Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats by Cai, Lu, Chen, Shali, Evans, Terry, Cherian, M George, Chakrabarti, Subrata

“…In the present study, the role of endothelin-1 (ET-1) on alterations of hepatic and renal metallothionein (MT) and trace metals (Zn, Cu, and Fe) were…”
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Metallothionein expression as prognostic factor for transitional cell carcinoma of bladder by Yamasaki, Yasuto, Smith, Cortney, Weisz, Dan, van Huizen, Isaac, Xuan, Jim, Moussa, Madeleine, Stitt, Larry, Hideki, Sakai, Cherian, M. George, Izawa, Jonathan I.

“…To determine whether metallothionein (MT) protein expression is associated with clinical outcomes in patients with transitional cell carcinoma (TCC) of the…”
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