Search Results - "Cherfils, J"

Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors by Zeghouf, M, Guibert, B, Zeeh, J-C, Cherfils, J

“…GEFs (guanine nucleotide-exchange factors), which stimulate GDP dissociation from small G-proteins, are pivotal regulators of signalling pathways activated by…”
Get more information

On the action of Brefeldin A on Sec7-stimulated membrane-recruitment and GDP/GTP exchange of Arf proteins by Cherfils, J, Melançon, P

“…Arf (ADP-ribosylation factor) proteins form a special class of small GTP-binding proteins in that their activation by GDP/GTP exchange is coupled to their…”
Get more information

RhoGDI-3, a promising system to investigate the regulatory function of rhoGDIs: uncoupling of inhibitory and shuttling functions of rhoGDIs by Dransart, E, Morin, A, Cherfils, J, Olofsson, B

“…rhoGDIs (Rho GDP dissociation inhibitors) are postulated to regulate the activity and the localization of small G-proteins of the Rho family by a shuttling…”
Get more information

Crystal structures of GMP kinase in complex with ganciclovir monophosphate and Ap5G by Hible, G., Daalova, P., Gilles, A.-M., Cherfils, J.

“…Guanosine monophosphate kinases (GMPK), by catalyzing the phosphorylation of GMP or dGMP, are of dual potential in assisting the activation of anti-viral…”
Get full text

Structure of the small G protein Rap2 in a non-catalytic complex with GTP by Ménétrey, J., Cherfils, J.

“…We report a novel crystal form of the small G protein Rap2A in complex with GTP which has no GTPase activity in the crystal. The asymmetric unit contains two…”
Get full text

JOSEPHINE: A parallel SPH code for free-surface flows by Cherfils, J.M., Pinon, G., Rivoalen, E.

“…JOSEPHINE is a parallel Smoothed Particle Hydrodynamics program, designed to solve unsteady free-surface flows. The adopted numerical scheme is efficient and…”
Get full text

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor by Cherfils, Jacqueline, Renault, Louis, Guibert, Bernard

“…Small GTP-binding (G) proteins are activated by GDP/GTP nucleotide exchange stimulated by guanine nucleotide exchange factors (GEFs). Nucleotide dissociation…”
Get full text

Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery by Pommier, Yves, Cherfils, Jacqueline

“…One of nature's strategies for interfering with molecular interactions is to trap macromolecules in transition states with their partners in dead-end complexes…”
Get full text

Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication by Pasqualato, Sebastiano, Renault, Louis, Cherfils, Jacqueline

“…Arf proteins are important regulators of cellular traffic and the founding members of an expanding family of homologous proteins and genomic sequences. They…”
Get full text

Regulation of ArfGTPases in cellular traffic by Cherfils, J.

“…Abstract only…”
Get full text

GEFs: structural basis for their activation of small GTP-binding proteins by Cherfils, Jacqueline, Chardin, Pierre

“…Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and…”
Get full text

Molecular docking programs successfully predict the binding of a β-lactamase inhibitory protein to TEM-1 β-lactamase by Strynadka, N.C.J, Eisenstein, M, Katchalski-Katzir, E, Shoichet, B.K, Kuntz, I.D, Abagyan, R, Totrov, M, Janin, J, Cherfils, J, Zimmerman, F, Olson, A, Duncan, B, Rao, M, Jackson, R, Sternberg, M, James, M.N.G

“…Crystallization of the 1:1 molecular complex between the beta-lactamase TEM-1 and the beta-lactamase inhibitory protein BLIP has provided an opportunity to put…”
Get full text

Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins by Kahn, Richard A, Cherfils, Jacqueline, Elias, Marek, Lovering, Ruth C, Munro, Sean, Schurmann, Annette

“…The Ras superfamily is comprised of at least four large families of regulatory guanosine triphosphate-binding proteins, including the Arfs. The Arf family…”
Get full text

RhoGDIs Revisited: Novel Roles in Rho Regulation by Dransart, Estelle, Olofsson, Birgitta, Cherfils, Jacqueline

“…Small GTP‐binding proteins of the Rho/Rac/Cdc42 family combine their GDP/GTP cycle, regulated by guanine nucleotide‐exchange factors and GTPase‐activating…”
Get full text

Activation of G-protein Gα subunits by receptors through Gα–Gβ and Gα–Gγ interactions by Cherfils, Jacqueline, Chabre, Marc

“…Activation of the Gα subunit of heterotrimeric GTP-binding proteins by transmembrane receptors requires the propagation of structural signals from the…”
Get full text

Structural Principles for the Multispecificity of Small GTP-Binding Proteins by Biou, Valérie, Cherfils, Jacqueline

“…The functional diversity of small GTP-binding proteins (G proteins) and their ability to function as molecular switches are based on their interactions with…”
Get full text

Heterotropic Interactions in Aspartate Transcarbamoylase: Turning Allosteric ATP Activation into Inhibition as a Consequence of a Single Tyrosine to Phenylalanine Mutation by Van Vliet, Francoise, Xu-Guang Xi, De Staercke, Christine, de Wannemaeker, Benedicte, Jacobs, Annemie, Cherfils, Jacqueline, Ladjimi, Moncef M., Herve, Guy, Cunin, Raymond

“…Aspartate transcarbamoylase (EC 2.1.3.2) is extensively studied as a model for cooperativity and allostery. This enzyme shows cooperativity between the…”
Get full text

Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex: Involvement of Specific Residues of the Sec7 Domain by Peyroche, Anne, Antonny, Bruno, Robineau, Sylviane, Acker, Joel, Cherfils, Jacqueline, Jackson, Catherine L.

“…We demonstrate that the major in vivo targets of brefeldin A (BFA) in the secretory pathway of budding yeast are the three members of the Sec7 domain family of…”
Get full text

X-ray structure of nucleoside diphosphate kinase complexed with thymidine diphosphate and Mg2+ at 2-.ANG. resolution by Cherfils, J, Morera, S, Lascu, I, Veron, M, Janin, J

Get full text

Crystallographic Evidence for Substrate-Assisted GTP Hydrolysis by a Small GTP Binding Protein by Pasqualato, Sebastiano, Cherfils, Jacqueline

“…GTP hydrolysis by small GTP binding proteins of the Ras superfamily is a universal reaction that controls multiple cellular regulations. Its enzymic mechanism…”
Get full text