Search Results - "Chepanova, Arina A"

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 by Zakharenko, Alexandra L, Luzina, Olga A, Chepanova, Arina A, Dyrkheeva, Nadezhda S, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important repair enzyme that removes various covalent adducts from the 3' end of DNA. Particularly, covalent…”
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New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan by Khomenko, Tatyana M, Zakharenko, Alexandra L, Kornienko, Tatyana E, Chepanova, Arina A, Dyrkheeva, Nadezhda S, Artemova, Anastasia O, Korchagina, Dina V, Achara, Chigozie, Curtis, Anthony, Reynisson, Jóhannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is an important enzyme in the DNA repair system. The ability of the enzyme to repair DNA damage induced by a…”
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New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors by Filimonov, Aleksander S, Chepanova, Arina A, Luzina, Olga A, Zakharenko, Alexandra L, Zakharova, Olga D, Ilina, Ekaterina S, Dyrkheeva, Nadezhda S, Kuprushkin, Maxim S, Kolotaev, Anton V, Khachatryan, Derenik S, Patel, Jinal, Leung, Ivanhoe K H, Chand, Raina, Ayine-Tora, Daniel M, Reynisson, Johannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can…”
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Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1 by Il'ina, Irina V, Dyrkheeva, Nadezhda S, Zakharenko, Alexandra L, Sidorenko, Alexander Yu, Li-Zhulanov, Nikolay S, Korchagina, Dina V, Chand, Raina, Ayine-Tora, Daniel M, Chepanova, Arina A, Zakharova, Olga D, Ilina, Ekaterina S, Reynisson, Jóhannes, Malakhova, Anastasia A, Medvedev, Sergey P, Zakian, Suren M, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Two novel structural types of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors with hexahydroisobenzofuran and 3-oxabicyclo [3.3.1]nonane scaffolds were…”
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Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy by Khomenko, Tatyana M, Zakharenko, Alexandra L, Chepanova, Arina A, Ilina, Ekaterina S, Zakharova, Olga D, Kaledin, Vasily I, Nikolin, Valeriy P, Popova, Nelly A, Korchagina, Dina V, Reynisson, Jóhannes, Chand, Raina, Ayine-Tora, Daniel M, Patel, Jinal, Leung, Ivanhoe K H, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new…”
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Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors-New Usnic Acid Derivatives by Kornienko, Tatyana E, Chepanova, Arina A, Zakharenko, Alexandra L, Filimonov, Aleksandr S, Luzina, Olga A, Dyrkheeva, Nadezhda S, Nikolin, Valeriy P, Popova, Nelly A, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme and one of the causes of tumor resistance to topoisomerase 1 inhibitors such as…”
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Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments by Munkuev, Aldar A., Mozhaitsev, Evgenii S., Chepanova, Arina A., Suslov, Evgeniy V., Korchagina, Dina V., Zakharova, Olga D., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Zakharenko, Alexandra L., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison,…”
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Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors by Gladkova, Elizaveta D, Chepanova, Arina A, Ilina, Ekaterina S, Zakharenko, Alexandra L, Reynisson, Jóhannes, Luzina, Olga A, Volcho, Konstantin P, Lavrik, Olga I, Salakhutdinov, Nariman F

“…A new type of berberine derivatives was obtained by the reaction of berberrubine with aliphatic sulfonyl chlorides. The new polycyclic compounds have a sultone…”
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A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold by Li-Zhulanov, Nikolai, Zakharenko, Alexandra, Chepanova, Arina, Patel, Jinal, Zafar, Ayesha, Volcho, Konstantin, Salakhutdinov, Nariman, Reynisson, Jóhannes, Leung, Ivanhoe, Lavrik, Olga

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the…”
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The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme by Gladkova, Elizaveta D, Nechepurenko, Ivan V, Bredikhin, Roman A, Chepanova, Arina A, Zakharenko, Alexandra L, Luzina, Olga A, Ilina, Ekaterina S, Dyrkheeva, Nadezhda S, Mamontova, Evgeniya M, Anarbaev, Rashid O, Reynisson, Jóhannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…A series of berberine and tetrahydroberberine sulfonate derivatives were prepared and tested against the tyrosyl-DNA phosphodiesterase 1 (Tdp1) DNA-repair…”
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Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments by Mozhaitsev, Evgenii S, Zakharenko, Alexandra L, Suslov, Evgeniy V, Korchagina, Dina V, Zakharova, Olga D, Vasil'eva, Inna A, Chepanova, Arina A, Black, Ellena, Patel, Jinal, Chand, Raina, Reynisson, Jóhannes, Leung, Ivanhoe K H, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…The DNA repair enzyme tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a current inhibition target to improve the efficacy of cancer chemotherapy. Previous studies…”
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The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges by Chepanova, Arina A., Mozhaitsev, Evgenii S., Munkuev, Aldar A., Suslov, Evgeniy V., Korchagina, Dina V., Zakharova, Olga D., Zakharenko, Alexandra L., Patel, Jinal, Ayine-Tora, Daniel M., Reynisson, Jóhannes, Leung, Ivanhoe K. H., Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.

“…Eleven amide and thioamide derivatives with monoterpene and adamantine substituents were synthesised. They were tested for their activity against the…”
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Deoxycholic acid as a molecular scaffold for tyrosyl-DNA phosphodiesterase 1 inhibition: A synthesis, structure–activity relationship and molecular modeling study by Salomatina, Oksana V., Popadyuk, Irina I., Zakharenko, Alexandra L., Zakharova, Olga D., Chepanova, Arina A., Dyrkheeva, Nadezhda.S., Komarova, Nina I., Reynisson, Jóhannes, Anarbaev, Rashid O., Salakhutdinov, Nariman F., Lavrik, Olga I., Volcho, Konstantin P.

“…[Display omitted] •para-Bromoanilides of deoxycholic acid derivatives were designed and synthesized.•All target compounds were evaluated as inhibitors of…”
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A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2 H -chromen-4-ol Scaffold by Li-Zhulanov, Nikolai S, Zakharenko, Alexandra L, Chepanova, Arina A, Patel, Jinal, Zafar, Ayesha, Volcho, Konstantin P, Salakhutdinov, Nariman F, Reynisson, Jóhannes, Leung, Ivanhoe K H, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the…”
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