Search Results - "Chenoweth, M"

Rational design of small molecule fluorescent probes for biological applications by Jun, Joomyung V, Chenoweth, David M, Petersson, E James

“…Fluorescent small molecules are powerful tools for visualizing biological events, embodying an essential facet of chemical biology. Since the discovery of the…”
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Spindle asymmetry drives non-Mendelian chromosome segregation by Akera, Takashi, Chmátal, Lukáš, Trimm, Emily, Yang, Karren, Aonbangkhen, Chanat, Chenoweth, David M., Janke, Carsten, Schultz, Richard M., Lampson, Michael A.

“…Genetic elements compete for transmission through meiosis, when haploid gametes are created from a diploid parent. Selfish elements can enhance their…”
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Nuclear body phase separation drives telomere clustering in ALT cancer cells by Zhang, Huaiying, Zhao, Rongwei, Tones, Jason, Liu, Michel, Dilley, Robert L., Chenoweth, David M., Greenberg, Roger A., Lampson, Michael A.

“…A chemical dimerization approach is developed to induce phase separation of APB nuclear bodies involved in telomere elongation in alternative lengthening of…”
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The Human FcγRII (CD32) Family of Leukocyte FcR in Health and Disease by Anania, Jessica C, Chenoweth, Alicia M, Wines, Bruce D, Hogarth, P Mark

“…FcγRs have been the focus of extensive research due to their key role linking innate and humoral immunity and their implication in both inflammatory and…”
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Localized light-induced protein dimerization in living cells using a photocaged dimerizer by Ballister, Edward R., Aonbangkhen, Chanat, Mayo, Alyssa M., Lampson, Michael A., Chenoweth, David M.

“…Regulated protein localization is critical for many cellular processes. Several techniques have been developed for experimental control over protein…”
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Solid-Phase Photochemical Decarboxylative Hydroalkylation of Peptides by Elkhalifa, Mahmoud, Elbaum, Michael B, Chenoweth, David M, Molander, Gary A

“…The compatibility of photochemistry with solid-phase peptide synthesis is demonstrated via photochemical hydroalkylation to form C­(sp3)–C­(sp3) bonds between…”
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Allosteric modulation of DNA by small molecules by Chenoweth, David M, Dervan, Peter B

“…Many human diseases are caused by dysregulated gene expression. The oversupply of transcription factors may be required for the growth and metastatic behavior…”
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Photoelectrocyclization as an Activation Mechanism for Organelle-Specific Live-Cell Imaging Probes by Tran, Mai N., Chenoweth, David M.

“…Photoactivatable fluorophores are useful tools in live‐cell imaging owing to their potential for precise spatial and temporal control. In this report, a new…”
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Reversible Control of Protein Localization in Living Cells Using a Photocaged-Photocleavable Chemical Dimerizer by Aonbangkhen, Chanat, Zhang, Huaiying, Wu, Daniel Z, Lampson, Michael A, Chenoweth, David M

“…Many dynamic biological processes are regulated by protein–protein interactions and protein localization. Experimental techniques to probe such processes with…”
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Recognition of Nucleic Acid Junctions Using Triptycene-Based Molecules by Barros, Stephanie A., Chenoweth, David M.

“…The modulation of nucleic acids by small molecules is an essential process across the kingdoms of life. Targeting nucleic acids with small molecules represents…”
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Optogenetic control of kinetochore function by Zhang, Huaiying, Aonbangkhen, Chanat, Tarasovetc, Ekaterina V, Ballister, Edward R, Chenoweth, David M, Lampson, Michael A

“…The development of two new optogenetic dimerizers—CTH, which promoted uncaging with less light and longer wavelengths, and TNH, a reversible dimerizer—enabled…”
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Ataluren binds to multiple protein synthesis apparatus sites and competitively inhibits release factor-dependent termination by Huang, Shijie, Bhattacharya, Arpan, Ghelfi, Mikel D., Li, Hong, Fritsch, Clark, Chenoweth, David M., Goldman, Yale E., Cooperman, Barry S.

“…Genetic diseases are often caused by nonsense mutations, but only one TRID (translation readthrough inducing drug), ataluren, has been approved for clinical…”
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Tension promotes kinetochore-microtubule release by Aurora B kinase by Chen, Geng-Yuan, Renda, Fioranna, Zhang, Huaiying, Gokden, Alper, Wu, Daniel Z, Chenoweth, David M, Khodjakov, Alexey, Lampson, Michael A

“…To ensure accurate chromosome segregation, interactions between kinetochores and microtubules are regulated by a combination of mechanics and biochemistry…”
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Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding by Chenoweth, David M, Dervan, Peter B

“…Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription…”
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Ultrafast Solvation Dynamics and Vibrational Coherences of Halogenated Boron-Dipyrromethene Derivatives Revealed through Two-Dimensional Electronic Spectroscopy by Lee, Yumin, Das, Saptaparna, Malamakal, Roy M, Meloni, Stephen, Chenoweth, David M, Anna, Jessica M

“…Boron-dipyrromethene (BODIPY) chromophores have a wide range of applications, spanning areas from biological imaging to solar energy conversion. Understanding…”
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Shape changing thin films powered by DNA hybridization by Shim, Tae Soup, Estephan, Zaki G., Qian, Zhaoxia, Prosser, Jacob H., Lee, Su Yeon, Chenoweth, David M., Lee, Daeyeon, Park, So-Jung, Crocker, John C.

“…DNA-grafted gold nanoparticles can self-assemble into shape-changing films that are powered by DNA strand exchange reactions and have two different domains…”
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TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells by Xu, Meng, Senanayaka, Dulmi, Zhao, Rongwei, Chigumira, Tafadzwa, Tripathi, Astha, Tones, Jason, Lackner, Rachel M., Wondisford, Anne R., Moneysmith, Laurel N., Hirschi, Alexander, Craig, Sara, Alishiri, Sahar, O’Sullivan, Roderick J., Chenoweth, David M., Reiter, Nicholas J., Zhang, Huaiying

“…The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway…”
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Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization by Ballister, Edward R., Ayloo, Swathi, Chenoweth, David M., Lampson, Michael A., Holzbaur, Erika L.F.

“…Cell polarity, growth and signaling require organelle transport by cytoskeletal motor proteins that are precisely regulated in time and space. Probing these…”
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Aza-proline effectively mimics l -proline stereochemistry in triple helical collagen by Kasznel, Alexander J., Harris, Trevor, Porter, Nicholas J., Zhang, Yitao, Chenoweth, David M.

“…The prevalence of l -amino acids in biomolecules has been shown to have teleological importance in biomolecular structure and self-assembly. Recently,…”
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Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 by Chauhan, Jitesh, Grandits, Melanie, Palhares, Lais C. G. F., Mele, Silvia, Nakamura, Mano, López-Abente, Jacobo, Crescioli, Silvia, Laddach, Roman, Romero-Clavijo, Pablo, Cheung, Anthony, Stavraka, Chara, Chenoweth, Alicia M., Sow, Heng Sheng, Chiaruttini, Giulia, Gilbert, Amy E., Dodev, Tihomir, Koers, Alexander, Pellizzari, Giulia, Ilieva, Kristina M., Man, Francis, Ali, Niwa, Hobbs, Carl, Lombardi, Sara, Lionarons, Daniël A., Gould, Hannah J., Beavil, Andrew J., Geh, Jenny L. C., MacKenzie Ross, Alastair D., Healy, Ciaran, Calonje, Eduardo, Downward, Julian, Nestle, Frank O., Tsoka, Sophia, Josephs, Debra H., Blower, Philip J., Karagiannis, Panagiotis, Lacy, Katie E., Spicer, James, Karagiannis, Sophia N., Bax, Heather J.

“…Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated…”
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