Search Results - "Chenoweth, Josh G"

Epigenomic Comparison Reveals Activation of “Seed” Enhancers during Transition from Naive to Primed Pluripotency by Factor, Daniel C., Corradin, Olivia, Zentner, Gabriel E., Saiakhova, Alina, Song, Lingyun, Chenoweth, Josh G., McKay, Ronald D., Crawford, Gregory E., Scacheri, Peter C., Tesar, Paul J.

“…Naive mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs) represent successive snapshots of pluripotency during embryogenesis. Using…”
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Isolation of Epiblast Stem Cells from Preimplantation Mouse Embryos by Najm, Fadi J., Chenoweth, Josh G., Anderson, Philip D., Nadeau, Joseph H., Redline, Raymond W., McKay, Ronald D.G., Tesar, Paul J.

“…Pluripotent stem cells provide a platform to interrogate control elements that function to generate all cell types of the body. Despite their utility for…”
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Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells by Kuzmichev, Andrey N., Kim, Suel-Kee, D’Alessio, Ana C., Chenoweth, Josh G., Wittko, Ina M., Campanati, Loraine, McKay, Ronald D.

“…Sox2 is an important transcriptional regulator in embryonic and adult stem cells [1–4]. Recently, Sox2 was identified as an oncogene in many endodermal…”
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Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes by Chenoweth, Josh G., Colantuoni, Carlo, Striegel, Deborah A., Genzor, Pavol, Brandsma, Joost, Blair, Paul W., Krishnan, Subramaniam, Chiyka, Elizabeth, Fazli, Mehran, Mehta, Rittal, Considine, Michael, Cope, Leslie, Knight, Audrey C., Elayadi, Anissa, Fox, Anne, Hertzano, Ronna, Letizia, Andrew G., Owusu-Ofori, Alex, Boakye, Isaac, Aduboffour, Albert A., Ansong, Daniel, Biney, Eno, Oduro, George, Schully, Kevin L., Clark, Danielle V.

“…Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There…”
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Direct and Indirect Contribution of Human Embryonic Stem Cell–Derived Hepatocyte-Like Cells to Liver Repair in Mice by Woo, Dong–Hun, Kim, Suel–Kee, Lim, Hee–Joung, Heo, Jeonghoon, Park, Hyung Soon, Kang, Gum–Yong, Kim, Sung–Eun, You, Hyun–Ju, Hoeppner, Daniel J, Kim, Youngchul, Kwon, Heechung, Choi, Tae Hyun, Lee, Joo Hee, Hong, Su Hee, Song, Kang Won, Ahn, Eun–Kyung, Chenoweth, Josh G, Tesar, Paul J, McKay, Ronald D.G, Kim, Jong–Hoon

“…Background & Aims Many studies of embryonic stem cells have investigated direct cell replacement of damaged tissues, but little is known about how donor…”
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Directed Differentiation of Human Induced Pluripotent Stem Cells Toward Bone and Cartilage: In Vitro Versus In Vivo Assays by Phillips, Matthew D., Kuznetsov, Sergei A., Cherman, Natasha, Park, Kyeyoon, Chen, Kevin G., McClendon, Britney N., Hamilton, Rebecca S., McKay, Ronald D.G., Chenoweth, Josh G., Mallon, Barbara S., Robey, Pamela G.

“…The ability to generate large numbers of bone‐ and cartilage‐forming cells from induced pluripotent stem cells (iPSCs) would mark a major advance in tissue…”
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Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome by Xi, Hualin, Shulha, Hennady P, Lin, Jane M, Vales, Teresa R, Fu, Yutao, Bodine, David M, McKay, Ronald D G, Chenoweth, Josh G, Tesar, Paul J, Furey, Terrence S, Ren, Bing, Weng, Zhiping, Crawford, Gregory E

“…The identification of regulatory elements from different cell types is necessary for understanding the mechanisms controlling cell type-specific and…”
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StemCellDB: the human pluripotent stem cell database at the National Institutes of Health by Mallon, Barbara S, Chenoweth, Josh G, Johnson, Kory R, Hamilton, Rebecca S, Tesar, Paul J, Yavatkar, Amarendra S, Tyson, Leonard J, Park, Kyeyoon, Chen, Kevin G, Fann, Yang C, McKay, Ronald D G

“…Much of the excitement generated by induced pluripotent stem cell technology is concerned with the possibility of disease modeling as well as the potential for…”
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Speeding to Pluripotency by Chenoweth, Josh G., McKay, Ronald D.

“…Finding a cell that reprograms in a nonstochastic manner without genetic manipulation has proven elusive. In this issue, Guo et al. report the identification…”
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Use of postmortem human dura mater and scalp for deriving human fibroblast cultures by Bliss, Lindsay A, Sams, Malik R, Deep-Soboslay, Amy, Ren-Patterson, Renee, Jaffe, Andrew E, Chenoweth, Josh G, Jaishankar, Amritha, Kleinman, Joel E, Hyde, Thomas M

“…Fibroblasts can be collected from deceased individuals, grown in culture, reprogrammed into induced pluripotent stem cells (iPSCs), and then differentiated…”
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Sepsis endotypes identified by host gene expression across global cohorts by Chenoweth, Josh G., Brandsma, Joost, Striegel, Deborah A., Genzor, Pavol, Chiyka, Elizabeth, Blair, Paul W., Krishnan, Subramaniam, Dogbe, Elliot, Boakye, Isaac, Fogel, Gary B., Tsalik, Ephraim L., Woods, Christopher W., Owusu-Ofori, Alex, Oppong, Chris, Oduro, George, Vantha, Te, Letizia, Andrew G., Beckett, Charmagne G., Schully, Kevin L., Clark, Danielle V.

“…Background Sepsis from infection is a global health priority and clinical trials have failed to deliver effective therapeutic interventions. To address…”
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Epiblast stem cells contribute new insight into pluripotency and gastrulation by Chenoweth, Josh G, McKay, Ronald D.G, Tesar, Paul J

“…Gastrulation is the defining feature of metazoan development where it serves to apportion seemingly equivalent, pluripotent cells to specific fates. The three…”
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New cell lines from mouse epiblast share defining features with human embryonic stem cells by McKay, Ronald D. G, Brook, Frances A, Mack, David L, Gardner, Richard L, Chenoweth, Josh G, Davies, Timothy J, Evans, Edward P, Tesar, Paul J

“…The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES…”
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Efficient Serum‐Free Derivation of Oligodendrocyte Precursors from Neural Stem Cell‐Enriched Cultures by Rao, Rajesh C., Boyd, Justin, Padmanabhan, Raji, Chenoweth, Josh G., McKay, Ronald D.

“…Oligodendrocytes derived in the laboratory from stem cells have been proposed as a treatment for acute and chronic injury to the central nervous system…”
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Retrospective Analysis of Blood Biomarkers of Neurological Injury in Human Cases of Viral Infection and Bacterial Sepsis by Bartlett, Maggie L, Goux, Heather, Johnson, Linwood, Schully, Kevin L, Gregory, Melissa, Brandsma, Joost, Chenoweth, Josh G, Clark, Danielle V, Rivera, Luis Felipe, Lezcano-Coba, Carlos, Vittor, Amy Y, Hayes, Ronald, Galué, Josefrancisco, Carrera, Jean-Paul, Smith, Darci R

“…Blood biomarkers of neurological injury could provide a rapid diagnosis of central nervous system (CNS) injury caused by infections. An FDA-approved assay for…”
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Rapid, Low-Complexity, Simultaneous Bacterial Group Identification and Antimicrobial Susceptibility Testing Performed Directly on Positive Blood Culture Bottles Using Chromogenic Agar by Robberts, F J Lourens, Owusu-Ofori, Alex, Oduro, George, Gyampomah, Thomas K, Marles, Nisha, Fox, Anne T, Chenoweth, Josh G, Schully, Kevin L, Clark, Danielle V

“…The use of positive blood culture bottles for direct disk diffusion susceptibility testing (dDD), together with chromogenic culture limited to groups of…”
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Precision symptom phenotyping identifies early clinical and proteomic predictors of distinct COVID-19 sequelae by Epsi, Nusrat J, Chenoweth, Josh G, Blair, Paul W, Lindholm, David A, Ganesan, Anuradha, Lalani, Tahaniyat, Smith, Alfred, Mody, Rupal M, Jones, Milissa U, Colombo, Rhonda E, Colombo, Christopher J, Schofield, Christina, Ewers, Evan C, Larson, Derek T, Berjohn, Catherine M, Maves, Ryan C, Fries, Anthony C, Chang, David, Wyatt, Andrew, Scher, Ann I, Byrne, Celia, Rusiecki, Jennifer, Saunders, David L, Livezey, Jeffrey, Malloy, Allison, Bazan, Samantha, Maldonado, Carlos, Edwards, Margaret Sanchez, Mende, Katrin, Simons, Mark P, O'Connell, Robert J, Tribble, David R, Agan, Brian K, Burgess, Timothy H, Pollett, Simon D, Richard, Stephanie A

“…Post-COVID conditions (PCC) are difficult to characterize, diagnose, predict, and treat due to overlapping symptoms and poorly understood pathology…”
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Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients by Brandsma, Joost, Chenoweth, Josh G, Gregory, Melissa K, Krishnan, Subramaniam, Blair, Paul W, Striegel, Deborah A, Mehta, Rittal, Schully, Kevin L, Dumler, J. Stephen, Sikorski, CDR Cynthia S, O'Connor, Kelsey, Reichert-Scrivner, Susan A, Paguirigan, Carmen M, Uyehara, Catherine F. T, Ngauy, COL Viseth, Myers, Christopher A, Clark, Danielle V

“…Background Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in…”
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Point-of-care biomarker assay for rapid multiplexed detection of CRP and IP-10 by Wilson, Claire S, Vashi, Bhavya, Genzor, Pavol, Gregory, Melissa K, Yau, Jason, Wolfe, Lauren, Lochhead, Michael J, Papst, Phil, Pettrone, Kristen, Blair, Paul W, Krishnan, Subramaniam, Chenoweth, Josh G, Clark, Danielle V

“…Rapid and accurate measurements of immune protein markers are essential for diagnosis and treatment in all clinical settings. The recent pandemic has revealed…”
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COVID-19 Outcomes Among US Military Health System Beneficiaries Include Complications Across Multiple Organ Systems and Substantial Functional Impairment by Richard, Stephanie A, Pollett, Simon D, Lanteri, Charlotte A, Millar, Eugene V, Fries, Anthony C, Maves, Ryan C, Utz, Gregory C, Lalani, Tahaniyat, Smith, Alfred, Mody, Rupal M, Ganesan, Anuradha, Colombo, Rhonda E, Colombo, Christopher J, Lindholm, David A, Madar, Cristian, Chi, Sharon, Huprikar, Nikhil, Larson, Derek T, Bazan, Samantha E, English, Caroline, Parmelee, Edward, Mende, Katrin, Laing, Eric D, Broder, Christopher C, Blair, Paul W, Chenoweth, Josh G, Simons, Mark P, Tribble, David R, Agan, Brian K, Burgess, Timothy H

“…Abstract Background We evaluated clinical outcomes, functional burden, and complications 1 month after coronavirus disease 2019 (COVID-19) infection in a…”
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