Search Results - "Cheng, Tianlin"
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The modeling method for vibration characteristics analysis of composite laminated rotationally stiffened shell
Published in PloS one (18-06-2024)“…The composite laminated rotationally stiffened shell is widely applied in aviation, aerospace, ship, machinery and other fields. To investigate the vibration…”
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Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype
Published in Neuroscience bulletin (01-09-2021)“…Whether direct manipulation of Parkinson’s disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue…”
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Critical role of TRPC6 channels in VEGF-mediated angiogenesis
Published in Cancer letters (28-09-2009)“…Abstract Intracellular Ca2+ signaling plays critical roles in VEGF-mediated angiogenesis. Transient receptor potential canonical (TRPC) channel 6, a Ca2+…”
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Generation of a human iPSC line from a Parkinson’s disease patient with a novel CHCHD2 mutation (p.R145Q)
Published in Stem cell research (01-06-2024)“…Mutations in CHCHD2 have been reported to be associated with familial Parkinson’s disease (PD). We generated a human induced pluripotent stem cell (hiPSC) line…”
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The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation
Published in Molecular brain (18-04-2015)“…The tumor suppressor gene Phosphatase and tensin homolog (PTEN) is highly expressed in neural progenitor cells (NPCs) and plays an important role in…”
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A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections
Published in BMC genetics (21-08-2012)“…Autistic spectrum disorders (ASDs) are a family of neurodevelopmental disorders with strong genetic components. Recent studies have shown that copy number…”
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In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway
Published in Science advances (01-04-2019)“…Although Cas9-mediated genome editing has been widely used to engineer alleles in animal models of human inherited diseases, very few homology-directed repair…”
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Mir505-3p regulates axonal development via inhibiting the autophagy pathway by targeting Atg12
Published in Autophagy (03-10-2017)“…In addition to the canonical role in protein homeostasis, autophagy has recently been found to be involved in axonal dystrophy and neurodegeneration. Whether…”
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