Serotype distribution and antimicrobial resistance patterns of nasopharyngeal and invasive Streptococcus pneumoniae isolates in Hong Kong children

A study was conducted to determine the vaccine coverage of prevalent carriage and invasive pneumococci from children aged less than 6 years in Hong Kong. A total of 383 nasopharyngeal carriage isolates and 88 invasive isolates from diverse sources were serotyped and their antimicrobial susceptibilit...

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Bibliographic Details
Published in:	Vaccine Vol. 22; no. 25; pp. 3334 - 3339
Main Authors:	Ho, Pak Leung, Lam, Kwok Fai, Chow, Frankie K.H, Lau, Yu Lung, Wong, Samson S.Y, Cheng, Susan L.E, Chiu, Susan S
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 03-09-2004 Elsevier
Subjects:	Algorithms Anti-Bacterial Agents - pharmacology Applied microbiology Bacteriology Biological and medical sciences Carrier State - microbiology Child Child Day Care Centers Child, Preschool Drug resistance Drug Resistance, Bacterial Female Fundamental and applied biological sciences. Psychology Heptavalent pneumococcal conjugate vaccine Hong Kong Humans Male Mass Vaccination Microbial Sensitivity Tests Microbiology Miscellaneous Nasopharynx - microbiology Pneumococcal Infections - microbiology Pneumococcal Vaccines Serotyping Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Conjugate Hong Kong Asia China China, People's Rep., Hong Kong Drug resistance Heptavalent pneumococcal conjugate vaccine Streptococcus pneumoniae Human Vaccine Epidemiology Antimicrobial agent Resistance Streptococcaceae Bacteria Micrococcales Isolate Serotype Child
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Summary:	A study was conducted to determine the vaccine coverage of prevalent carriage and invasive pneumococci from children aged less than 6 years in Hong Kong. A total of 383 nasopharyngeal carriage isolates and 88 invasive isolates from diverse sources were serotyped and their antimicrobial susceptibilities determined. The most common carriage serotypes were the same as the invasive isolates (6B, 14, 19F and 23F), although the rank order of specific serotypes was different. Serotypes in the 7-valent conjugate pneumococcal vaccine (4, 6B, 9V, 14, 18C, 19F and 23F) accounted for 89.7 and 66.1% of the invasive and carriage isolates, respectively. The same seven serotypes comprised 87.5% invasive isolates and 82.8% carriage isolates with resistance to penicillin, erythromycin and/or cefotaxime.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2004.02.038